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Influence of age, gender, and race on nitric oxide release over acupuncture points-meridians.

Ma SX, Lee PC, Jiang I, Ma E, Hu JS, Li XY - Sci Rep (2015)

Bottom Line: In elder ages compared to adults, NO levels over the ventral forearm were significantly decreased over LU on radial regions but not altered over PC on medial regions.These results suggest a selective reduction of NO release over LU meridian with aging, which is consistent with a progressive decline in lung function and increase in chronic respiratory disease in elder ages.Both of them support somatic-organ connections in the meridian system associated with potential pathophysiological changes with aging.

View Article: PubMed Central - PubMed

Affiliation: LA BioMed Research Institute at Harbor-UCLA Medical Center and Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA and Harbor-UCLA Medical Center, Torrance, CA 90502.

ABSTRACT
This study examined the influence of age, gender and race on nitric oxide (NO) release over acupuncture points, meridian without acupoint, and non-meridian regions of the Pericardium (PC) and Bladder (BL) meridian as well as aging on LU meridian in 61 healthy subjects. Biocapture tubes were attached to the skin surface, and total nitrite and nitrate was biocaptured and quantified using chemiluminescence. In elder ages compared to adults, NO levels over the ventral forearm were significantly decreased over LU on radial regions but not altered over PC on medial regions. Conversely, NO content was elevated over BL regions only in overweight/obesity of elder ages. NO levels over PC regions were marginally elevated in overweight/obese males compared to females but did not alter between races. These results suggest a selective reduction of NO release over LU meridian with aging, which is consistent with a progressive decline in lung function and increase in chronic respiratory disease in elder ages. Increased NO levels along the BL meridian in older obese subjects may reflect a modified NO level along somatic-bladder pathway for counteracting bladder dysfunctions with aging. Both of them support somatic-organ connections in the meridian system associated with potential pathophysiological changes with aging.

No MeSH data available.


Related in: MedlinePlus

Representation of a biocapture device with a semi-cylindrical molded tube taped to the skin surface over meridians.The pericardium (PC), lung (LU), and bladder (BL) meridian lines and related acupuncture points are illustrated on the top left, top right, and bottom right panels. The region from PC 5 to PC 7 is defined as acupoint (3 acupoints), the distance between PC 3 and PC 4 is defined as meridian line without acupoint (MWOP), and non-meridian control region close to PC meridian (NMCR). The region overlapping LU 8 and LU 9 is defined as acupoint (2 acupoints), the distance between LU 6 and LU 7 represents MWOP, and NMCR as non-meridian area adjacent to the meridian. The region over BL 57 is defined as acupoint (1 acupoint), the distance between BL 55 and BL 56 represents MWOP, and NMCR as non-meridian area adjacent to the meridian. The device was adhered to the skin surface using a custom double-sided adhesive, and NO scavenging solution (100 μM PTIO) was injected into the tubing over the skin surface for 20 min in order to directly absorb NO. The PC, LU, and BL meridian lines and related acupuncture points are reproduced from J. A. Johnson, Chinese Medical Qigong Therapy: A Comprehensive Clinical Text, 2000.
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f1: Representation of a biocapture device with a semi-cylindrical molded tube taped to the skin surface over meridians.The pericardium (PC), lung (LU), and bladder (BL) meridian lines and related acupuncture points are illustrated on the top left, top right, and bottom right panels. The region from PC 5 to PC 7 is defined as acupoint (3 acupoints), the distance between PC 3 and PC 4 is defined as meridian line without acupoint (MWOP), and non-meridian control region close to PC meridian (NMCR). The region overlapping LU 8 and LU 9 is defined as acupoint (2 acupoints), the distance between LU 6 and LU 7 represents MWOP, and NMCR as non-meridian area adjacent to the meridian. The region over BL 57 is defined as acupoint (1 acupoint), the distance between BL 55 and BL 56 represents MWOP, and NMCR as non-meridian area adjacent to the meridian. The device was adhered to the skin surface using a custom double-sided adhesive, and NO scavenging solution (100 μM PTIO) was injected into the tubing over the skin surface for 20 min in order to directly absorb NO. The PC, LU, and BL meridian lines and related acupuncture points are reproduced from J. A. Johnson, Chinese Medical Qigong Therapy: A Comprehensive Clinical Text, 2000.

Mentions: Figure 1 is a representative example of the defined PC, BL, and LU acupoints, MWOP, and NMCR. A biocapture device with a semi-cylindrical molded tube was adhered to the skin surface (top central and bottom left panels) over the PC regions (top left panel) and LU regions (top right panel), and BL regions (bottom right panel).


Influence of age, gender, and race on nitric oxide release over acupuncture points-meridians.

Ma SX, Lee PC, Jiang I, Ma E, Hu JS, Li XY - Sci Rep (2015)

Representation of a biocapture device with a semi-cylindrical molded tube taped to the skin surface over meridians.The pericardium (PC), lung (LU), and bladder (BL) meridian lines and related acupuncture points are illustrated on the top left, top right, and bottom right panels. The region from PC 5 to PC 7 is defined as acupoint (3 acupoints), the distance between PC 3 and PC 4 is defined as meridian line without acupoint (MWOP), and non-meridian control region close to PC meridian (NMCR). The region overlapping LU 8 and LU 9 is defined as acupoint (2 acupoints), the distance between LU 6 and LU 7 represents MWOP, and NMCR as non-meridian area adjacent to the meridian. The region over BL 57 is defined as acupoint (1 acupoint), the distance between BL 55 and BL 56 represents MWOP, and NMCR as non-meridian area adjacent to the meridian. The device was adhered to the skin surface using a custom double-sided adhesive, and NO scavenging solution (100 μM PTIO) was injected into the tubing over the skin surface for 20 min in order to directly absorb NO. The PC, LU, and BL meridian lines and related acupuncture points are reproduced from J. A. Johnson, Chinese Medical Qigong Therapy: A Comprehensive Clinical Text, 2000.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664911&req=5

f1: Representation of a biocapture device with a semi-cylindrical molded tube taped to the skin surface over meridians.The pericardium (PC), lung (LU), and bladder (BL) meridian lines and related acupuncture points are illustrated on the top left, top right, and bottom right panels. The region from PC 5 to PC 7 is defined as acupoint (3 acupoints), the distance between PC 3 and PC 4 is defined as meridian line without acupoint (MWOP), and non-meridian control region close to PC meridian (NMCR). The region overlapping LU 8 and LU 9 is defined as acupoint (2 acupoints), the distance between LU 6 and LU 7 represents MWOP, and NMCR as non-meridian area adjacent to the meridian. The region over BL 57 is defined as acupoint (1 acupoint), the distance between BL 55 and BL 56 represents MWOP, and NMCR as non-meridian area adjacent to the meridian. The device was adhered to the skin surface using a custom double-sided adhesive, and NO scavenging solution (100 μM PTIO) was injected into the tubing over the skin surface for 20 min in order to directly absorb NO. The PC, LU, and BL meridian lines and related acupuncture points are reproduced from J. A. Johnson, Chinese Medical Qigong Therapy: A Comprehensive Clinical Text, 2000.
Mentions: Figure 1 is a representative example of the defined PC, BL, and LU acupoints, MWOP, and NMCR. A biocapture device with a semi-cylindrical molded tube was adhered to the skin surface (top central and bottom left panels) over the PC regions (top left panel) and LU regions (top right panel), and BL regions (bottom right panel).

Bottom Line: In elder ages compared to adults, NO levels over the ventral forearm were significantly decreased over LU on radial regions but not altered over PC on medial regions.These results suggest a selective reduction of NO release over LU meridian with aging, which is consistent with a progressive decline in lung function and increase in chronic respiratory disease in elder ages.Both of them support somatic-organ connections in the meridian system associated with potential pathophysiological changes with aging.

View Article: PubMed Central - PubMed

Affiliation: LA BioMed Research Institute at Harbor-UCLA Medical Center and Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA and Harbor-UCLA Medical Center, Torrance, CA 90502.

ABSTRACT
This study examined the influence of age, gender and race on nitric oxide (NO) release over acupuncture points, meridian without acupoint, and non-meridian regions of the Pericardium (PC) and Bladder (BL) meridian as well as aging on LU meridian in 61 healthy subjects. Biocapture tubes were attached to the skin surface, and total nitrite and nitrate was biocaptured and quantified using chemiluminescence. In elder ages compared to adults, NO levels over the ventral forearm were significantly decreased over LU on radial regions but not altered over PC on medial regions. Conversely, NO content was elevated over BL regions only in overweight/obesity of elder ages. NO levels over PC regions were marginally elevated in overweight/obese males compared to females but did not alter between races. These results suggest a selective reduction of NO release over LU meridian with aging, which is consistent with a progressive decline in lung function and increase in chronic respiratory disease in elder ages. Increased NO levels along the BL meridian in older obese subjects may reflect a modified NO level along somatic-bladder pathway for counteracting bladder dysfunctions with aging. Both of them support somatic-organ connections in the meridian system associated with potential pathophysiological changes with aging.

No MeSH data available.


Related in: MedlinePlus