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Systolic aortic pressure-time area is a useful index describing arterial wave properties in rats with diabetes.

Chang RW, Chang CY, Wu MS, Yu HY, Luo JM, Chen YS, Lin FY, Lai LC, Wang CH, Chang KC - Sci Rep (2015)

Bottom Line: The accurate measurement of arterial wave properties in terms of arterial wave transit time (τw) and wave reflection factor (Rf) requires simultaneous records of aortic pressure and flow signals.However, in clinical practice, it will be helpful to describe the pulsatile ventricular afterload using less-invasive parameters if possible.Arterial wave reflections were derived using the impulse response function of the filtered aortic input impedance spectra.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, College of Medicine, National Taiwan University, Taipei, 100, Taiwan.

ABSTRACT
The accurate measurement of arterial wave properties in terms of arterial wave transit time (τw) and wave reflection factor (Rf) requires simultaneous records of aortic pressure and flow signals. However, in clinical practice, it will be helpful to describe the pulsatile ventricular afterload using less-invasive parameters if possible. We investigated the possibility of systolic aortic pressure-time area (PTAs), calculated from the measured aortic pressure alone, acting as systolic workload imposed on the rat diabetic heart. Arterial wave reflections were derived using the impulse response function of the filtered aortic input impedance spectra. The cardiovascular condition in the rats with either type 1 or type 2 diabetes was characterized by (1) an elevation in PTAs; and (2) an increase in Rf and decrease in τw. We found that an inverse linear correlation between PTAs and arterial τw reached significance (τw = 38.5462 - 0.0022 × PTAs; r = 0.7708, P < 0.0001). By contrast, as the PTAs increased, the reflection intensity increased: Rf = -0.5439 + 0.0002 × PTAs; r = 0.8701; P <0 .0001. All these findings suggested that as diabetes stiffened aortas, the augmented aortic PTAs might act as a useful index describing the diabetes-related deterioration in systolic ventricular workload.

No MeSH data available.


Related in: MedlinePlus

Potential role of aortic PTAs in reflecting arterial wave properties and predicting LV isovolumic pressure relaxation.The arterial τw was significantly inversely related to the PTAs (A). By contrast, as the PTAs increased, the reflection intensity (arterial Rf) increased (B). A positive linear correlation existed between the LV τe and aortic PTAs (C), indicating that in diabetes, the PTAs increases and the prolonged LV τe slows the late pressure relaxation. LV, left ventricular; PTAs, systolic aortic pressure-time area; Rf, wave reflection factor; τe, time constant of the LV isovolumic pressure decay; τw, wave transit time.
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f4: Potential role of aortic PTAs in reflecting arterial wave properties and predicting LV isovolumic pressure relaxation.The arterial τw was significantly inversely related to the PTAs (A). By contrast, as the PTAs increased, the reflection intensity (arterial Rf) increased (B). A positive linear correlation existed between the LV τe and aortic PTAs (C), indicating that in diabetes, the PTAs increases and the prolonged LV τe slows the late pressure relaxation. LV, left ventricular; PTAs, systolic aortic pressure-time area; Rf, wave reflection factor; τe, time constant of the LV isovolumic pressure decay; τw, wave transit time.

Mentions: By taking PTAs as the dependent variable and arterial Rf and τw as the two independent variables, multiple linear regression shown in Fig. 3 exhibited a favorable correlation among the three parameters (PTAs = 7584.5 + 3637.3 × Rf  – 107.6 × τw; r = 0.8952, P < .0001). Figure 4 shows the ability of PTAs to predict arterial wave properties and LV isovolumic pressure relaxation in diabetes. The inverse linear correlation between PTAs and arterial τw reached significance (τw = 38.5462 – 0.0022 × PTAs; r = 0.7708, P < .0001) (Fig. 4A). By contrast, PTAs had positive linear correlation with the arterial Rf : Rf = –0.5439 + 0.0002 × PTAs; r = 0.8701; P < .0001 (Fig. 4B). Moreover, the significant linear correlation between LV τe and PTAs was noted (τe = 0.3474 + 0.0016 × PTAs; r = 0.6013, P < .0001) (Fig. 4C).


Systolic aortic pressure-time area is a useful index describing arterial wave properties in rats with diabetes.

Chang RW, Chang CY, Wu MS, Yu HY, Luo JM, Chen YS, Lin FY, Lai LC, Wang CH, Chang KC - Sci Rep (2015)

Potential role of aortic PTAs in reflecting arterial wave properties and predicting LV isovolumic pressure relaxation.The arterial τw was significantly inversely related to the PTAs (A). By contrast, as the PTAs increased, the reflection intensity (arterial Rf) increased (B). A positive linear correlation existed between the LV τe and aortic PTAs (C), indicating that in diabetes, the PTAs increases and the prolonged LV τe slows the late pressure relaxation. LV, left ventricular; PTAs, systolic aortic pressure-time area; Rf, wave reflection factor; τe, time constant of the LV isovolumic pressure decay; τw, wave transit time.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664900&req=5

f4: Potential role of aortic PTAs in reflecting arterial wave properties and predicting LV isovolumic pressure relaxation.The arterial τw was significantly inversely related to the PTAs (A). By contrast, as the PTAs increased, the reflection intensity (arterial Rf) increased (B). A positive linear correlation existed between the LV τe and aortic PTAs (C), indicating that in diabetes, the PTAs increases and the prolonged LV τe slows the late pressure relaxation. LV, left ventricular; PTAs, systolic aortic pressure-time area; Rf, wave reflection factor; τe, time constant of the LV isovolumic pressure decay; τw, wave transit time.
Mentions: By taking PTAs as the dependent variable and arterial Rf and τw as the two independent variables, multiple linear regression shown in Fig. 3 exhibited a favorable correlation among the three parameters (PTAs = 7584.5 + 3637.3 × Rf  – 107.6 × τw; r = 0.8952, P < .0001). Figure 4 shows the ability of PTAs to predict arterial wave properties and LV isovolumic pressure relaxation in diabetes. The inverse linear correlation between PTAs and arterial τw reached significance (τw = 38.5462 – 0.0022 × PTAs; r = 0.7708, P < .0001) (Fig. 4A). By contrast, PTAs had positive linear correlation with the arterial Rf : Rf = –0.5439 + 0.0002 × PTAs; r = 0.8701; P < .0001 (Fig. 4B). Moreover, the significant linear correlation between LV τe and PTAs was noted (τe = 0.3474 + 0.0016 × PTAs; r = 0.6013, P < .0001) (Fig. 4C).

Bottom Line: The accurate measurement of arterial wave properties in terms of arterial wave transit time (τw) and wave reflection factor (Rf) requires simultaneous records of aortic pressure and flow signals.However, in clinical practice, it will be helpful to describe the pulsatile ventricular afterload using less-invasive parameters if possible.Arterial wave reflections were derived using the impulse response function of the filtered aortic input impedance spectra.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, College of Medicine, National Taiwan University, Taipei, 100, Taiwan.

ABSTRACT
The accurate measurement of arterial wave properties in terms of arterial wave transit time (τw) and wave reflection factor (Rf) requires simultaneous records of aortic pressure and flow signals. However, in clinical practice, it will be helpful to describe the pulsatile ventricular afterload using less-invasive parameters if possible. We investigated the possibility of systolic aortic pressure-time area (PTAs), calculated from the measured aortic pressure alone, acting as systolic workload imposed on the rat diabetic heart. Arterial wave reflections were derived using the impulse response function of the filtered aortic input impedance spectra. The cardiovascular condition in the rats with either type 1 or type 2 diabetes was characterized by (1) an elevation in PTAs; and (2) an increase in Rf and decrease in τw. We found that an inverse linear correlation between PTAs and arterial τw reached significance (τw = 38.5462 - 0.0022 × PTAs; r = 0.7708, P < 0.0001). By contrast, as the PTAs increased, the reflection intensity increased: Rf = -0.5439 + 0.0002 × PTAs; r = 0.8701; P <0 .0001. All these findings suggested that as diabetes stiffened aortas, the augmented aortic PTAs might act as a useful index describing the diabetes-related deterioration in systolic ventricular workload.

No MeSH data available.


Related in: MedlinePlus