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Systolic aortic pressure-time area is a useful index describing arterial wave properties in rats with diabetes.

Chang RW, Chang CY, Wu MS, Yu HY, Luo JM, Chen YS, Lin FY, Lai LC, Wang CH, Chang KC - Sci Rep (2015)

Bottom Line: The accurate measurement of arterial wave properties in terms of arterial wave transit time (τw) and wave reflection factor (Rf) requires simultaneous records of aortic pressure and flow signals.However, in clinical practice, it will be helpful to describe the pulsatile ventricular afterload using less-invasive parameters if possible.Arterial wave reflections were derived using the impulse response function of the filtered aortic input impedance spectra.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, College of Medicine, National Taiwan University, Taipei, 100, Taiwan.

ABSTRACT
The accurate measurement of arterial wave properties in terms of arterial wave transit time (τw) and wave reflection factor (Rf) requires simultaneous records of aortic pressure and flow signals. However, in clinical practice, it will be helpful to describe the pulsatile ventricular afterload using less-invasive parameters if possible. We investigated the possibility of systolic aortic pressure-time area (PTAs), calculated from the measured aortic pressure alone, acting as systolic workload imposed on the rat diabetic heart. Arterial wave reflections were derived using the impulse response function of the filtered aortic input impedance spectra. The cardiovascular condition in the rats with either type 1 or type 2 diabetes was characterized by (1) an elevation in PTAs; and (2) an increase in Rf and decrease in τw. We found that an inverse linear correlation between PTAs and arterial τw reached significance (τw = 38.5462 - 0.0022 × PTAs; r = 0.7708, P < 0.0001). By contrast, as the PTAs increased, the reflection intensity increased: Rf = -0.5439 + 0.0002 × PTAs; r = 0.8701; P <0 .0001. All these findings suggested that as diabetes stiffened aortas, the augmented aortic PTAs might act as a useful index describing the diabetes-related deterioration in systolic ventricular workload.

No MeSH data available.


Related in: MedlinePlus

Implication of arterial wave properties in PTAs.As shown by multiple linear regression analysis, the correlation between the aortic PTAs and the arterial τw and Rf reached significance, suggesting that the arterial wave properties impaired by diabetes could be reflected in the aortic PTAs. PTAs, systolic aortic pressure-time area; Rf, wave reflection factor; τw, wave transit time.
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f3: Implication of arterial wave properties in PTAs.As shown by multiple linear regression analysis, the correlation between the aortic PTAs and the arterial τw and Rf reached significance, suggesting that the arterial wave properties impaired by diabetes could be reflected in the aortic PTAs. PTAs, systolic aortic pressure-time area; Rf, wave reflection factor; τw, wave transit time.

Mentions: By taking PTAs as the dependent variable and arterial Rf and τw as the two independent variables, multiple linear regression shown in Fig. 3 exhibited a favorable correlation among the three parameters (PTAs = 7584.5 + 3637.3 × Rf  – 107.6 × τw; r = 0.8952, P < .0001). Figure 4 shows the ability of PTAs to predict arterial wave properties and LV isovolumic pressure relaxation in diabetes. The inverse linear correlation between PTAs and arterial τw reached significance (τw = 38.5462 – 0.0022 × PTAs; r = 0.7708, P < .0001) (Fig. 4A). By contrast, PTAs had positive linear correlation with the arterial Rf : Rf = –0.5439 + 0.0002 × PTAs; r = 0.8701; P < .0001 (Fig. 4B). Moreover, the significant linear correlation between LV τe and PTAs was noted (τe = 0.3474 + 0.0016 × PTAs; r = 0.6013, P < .0001) (Fig. 4C).


Systolic aortic pressure-time area is a useful index describing arterial wave properties in rats with diabetes.

Chang RW, Chang CY, Wu MS, Yu HY, Luo JM, Chen YS, Lin FY, Lai LC, Wang CH, Chang KC - Sci Rep (2015)

Implication of arterial wave properties in PTAs.As shown by multiple linear regression analysis, the correlation between the aortic PTAs and the arterial τw and Rf reached significance, suggesting that the arterial wave properties impaired by diabetes could be reflected in the aortic PTAs. PTAs, systolic aortic pressure-time area; Rf, wave reflection factor; τw, wave transit time.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664900&req=5

f3: Implication of arterial wave properties in PTAs.As shown by multiple linear regression analysis, the correlation between the aortic PTAs and the arterial τw and Rf reached significance, suggesting that the arterial wave properties impaired by diabetes could be reflected in the aortic PTAs. PTAs, systolic aortic pressure-time area; Rf, wave reflection factor; τw, wave transit time.
Mentions: By taking PTAs as the dependent variable and arterial Rf and τw as the two independent variables, multiple linear regression shown in Fig. 3 exhibited a favorable correlation among the three parameters (PTAs = 7584.5 + 3637.3 × Rf  – 107.6 × τw; r = 0.8952, P < .0001). Figure 4 shows the ability of PTAs to predict arterial wave properties and LV isovolumic pressure relaxation in diabetes. The inverse linear correlation between PTAs and arterial τw reached significance (τw = 38.5462 – 0.0022 × PTAs; r = 0.7708, P < .0001) (Fig. 4A). By contrast, PTAs had positive linear correlation with the arterial Rf : Rf = –0.5439 + 0.0002 × PTAs; r = 0.8701; P < .0001 (Fig. 4B). Moreover, the significant linear correlation between LV τe and PTAs was noted (τe = 0.3474 + 0.0016 × PTAs; r = 0.6013, P < .0001) (Fig. 4C).

Bottom Line: The accurate measurement of arterial wave properties in terms of arterial wave transit time (τw) and wave reflection factor (Rf) requires simultaneous records of aortic pressure and flow signals.However, in clinical practice, it will be helpful to describe the pulsatile ventricular afterload using less-invasive parameters if possible.Arterial wave reflections were derived using the impulse response function of the filtered aortic input impedance spectra.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, College of Medicine, National Taiwan University, Taipei, 100, Taiwan.

ABSTRACT
The accurate measurement of arterial wave properties in terms of arterial wave transit time (τw) and wave reflection factor (Rf) requires simultaneous records of aortic pressure and flow signals. However, in clinical practice, it will be helpful to describe the pulsatile ventricular afterload using less-invasive parameters if possible. We investigated the possibility of systolic aortic pressure-time area (PTAs), calculated from the measured aortic pressure alone, acting as systolic workload imposed on the rat diabetic heart. Arterial wave reflections were derived using the impulse response function of the filtered aortic input impedance spectra. The cardiovascular condition in the rats with either type 1 or type 2 diabetes was characterized by (1) an elevation in PTAs; and (2) an increase in Rf and decrease in τw. We found that an inverse linear correlation between PTAs and arterial τw reached significance (τw = 38.5462 - 0.0022 × PTAs; r = 0.7708, P < 0.0001). By contrast, as the PTAs increased, the reflection intensity increased: Rf = -0.5439 + 0.0002 × PTAs; r = 0.8701; P <0 .0001. All these findings suggested that as diabetes stiffened aortas, the augmented aortic PTAs might act as a useful index describing the diabetes-related deterioration in systolic ventricular workload.

No MeSH data available.


Related in: MedlinePlus