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Adaptations of the Secretome of Candida albicans in Response to Host-Related Environmental Conditions.

Klis FM, Brul S - Eukaryotic Cell (2015)

Bottom Line: Three β-1,3-glucan-modifying enzymes, Mp65, Sun41, and Tos1, are consistently found in large amounts in culture supernatants, suggesting that they are needed for construction and expansion of the cell wall β-1,3-glucan layer and thus correlate with growth and might serve as diagnostic biomarkers.Other abundant secretome proteins also contribute to biofilm formation, emphasizing the important role of secretome proteins in this mode of growth.Finally, we discuss the relevance of these observations to therapeutic intervention.

View Article: PubMed Central - PubMed

Affiliation: Department of Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands F.M.Klis@uva.nl.

No MeSH data available.


Related in: MedlinePlus

Major features of the secretome (sensu stricto) of C. albicans. The wall proteins are represented as short line segments perpendicular to the cell surface. M, mother cell; D, daughter cell; GPI-WP, GPI-modified wall protein. The role of Csa2 in heme binding is speculative (6, 40, 41). Note that Als3 and Phr1 are possibly directly released from the cell wall by Sap9/10 activity (47).
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Figure 1: Major features of the secretome (sensu stricto) of C. albicans. The wall proteins are represented as short line segments perpendicular to the cell surface. M, mother cell; D, daughter cell; GPI-WP, GPI-modified wall protein. The role of Csa2 in heme binding is speculative (6, 40, 41). Note that Als3 and Phr1 are possibly directly released from the cell wall by Sap9/10 activity (47).

Mentions: The experimentally identified secretome proteins (sensu stricto) (currently, about 70 [9–15]) can be classified into two major groups: nonglycosylphosphatidylinositol (non-GPI) proteins, which lack a C-terminal signal sequence for the addition of a GPI anchor in the endoplasmic reticulum, and GPI proteins (Fig. 1). To avoid an excessively long list, this review focuses on the more abundant secretome proteins that are observed under more than one growth condition and/or have a known or predicted function.


Adaptations of the Secretome of Candida albicans in Response to Host-Related Environmental Conditions.

Klis FM, Brul S - Eukaryotic Cell (2015)

Major features of the secretome (sensu stricto) of C. albicans. The wall proteins are represented as short line segments perpendicular to the cell surface. M, mother cell; D, daughter cell; GPI-WP, GPI-modified wall protein. The role of Csa2 in heme binding is speculative (6, 40, 41). Note that Als3 and Phr1 are possibly directly released from the cell wall by Sap9/10 activity (47).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664879&req=5

Figure 1: Major features of the secretome (sensu stricto) of C. albicans. The wall proteins are represented as short line segments perpendicular to the cell surface. M, mother cell; D, daughter cell; GPI-WP, GPI-modified wall protein. The role of Csa2 in heme binding is speculative (6, 40, 41). Note that Als3 and Phr1 are possibly directly released from the cell wall by Sap9/10 activity (47).
Mentions: The experimentally identified secretome proteins (sensu stricto) (currently, about 70 [9–15]) can be classified into two major groups: nonglycosylphosphatidylinositol (non-GPI) proteins, which lack a C-terminal signal sequence for the addition of a GPI anchor in the endoplasmic reticulum, and GPI proteins (Fig. 1). To avoid an excessively long list, this review focuses on the more abundant secretome proteins that are observed under more than one growth condition and/or have a known or predicted function.

Bottom Line: Three β-1,3-glucan-modifying enzymes, Mp65, Sun41, and Tos1, are consistently found in large amounts in culture supernatants, suggesting that they are needed for construction and expansion of the cell wall β-1,3-glucan layer and thus correlate with growth and might serve as diagnostic biomarkers.Other abundant secretome proteins also contribute to biofilm formation, emphasizing the important role of secretome proteins in this mode of growth.Finally, we discuss the relevance of these observations to therapeutic intervention.

View Article: PubMed Central - PubMed

Affiliation: Department of Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands F.M.Klis@uva.nl.

No MeSH data available.


Related in: MedlinePlus