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A global map of hemispheric influenza vaccine recommendations based on local patterns of viral circulation.

Alonso WJ, Yu C, Viboud C, Richard SA, Schuck-Paim C, Simonsen L, Mello WA, Miller MA - Sci Rep (2015)

Bottom Line: Both the Northern and the Southern Hemisphere annual WHO influenza vaccine recommendations are designed to ensure vaccine delivery before the winter-time peak of viral circulation in each hemisphere.Influenza vaccine recommendations for respectively 25% and 39% of the Northern and Southern Hemisphere countries were out of phase with peak influenza circulation in their corresponding hemisphere (62% and 53%, respectively, when the analysis was limited to the 52 countries in the tropical belt).These results indicate that routine influenza immunization efforts should be closely tailored to local patterns of viral circulation, rather than a country's hemispheric position.

View Article: PubMed Central - PubMed

Affiliation: National Institutes of Health, Fogarty International Center, Bethesda, MD, 20892, USA.

ABSTRACT
Both the Northern and the Southern Hemisphere annual WHO influenza vaccine recommendations are designed to ensure vaccine delivery before the winter-time peak of viral circulation in each hemisphere. However, influenza seasonal patterns are highly diverse in tropical countries and may be out of phase with the WHO recommendations for their respective hemisphere. We modelled the peak timing of influenza activity for 125 countries using laboratory-based surveillance data from the WHO's FLUNET database and compared it with the influenza hemispheric recommendations in place. Influenza vaccine recommendations for respectively 25% and 39% of the Northern and Southern Hemisphere countries were out of phase with peak influenza circulation in their corresponding hemisphere (62% and 53%, respectively, when the analysis was limited to the 52 countries in the tropical belt). These results indicate that routine influenza immunization efforts should be closely tailored to local patterns of viral circulation, rather than a country's hemispheric position.

No MeSH data available.


Related in: MedlinePlus

Optimal influenza vaccine recommendations for 125 countries contributing surveillance data (NH: Northern Hemisphere; SH: Southern Hemisphere).
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Related In: Results  -  Collection

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f2: Optimal influenza vaccine recommendations for 125 countries contributing surveillance data (NH: Northern Hemisphere; SH: Southern Hemisphere).

Mentions: Based on the estimated timing of the peak influenza activity, we classified all countries with respect to the vaccine they should adopt (Figs. 1, 2, S1 Table). In total, 26 countries of the Northern Hemisphere should opt for the vaccination recommendation currently targeted at Southern Hemisphere countries (the countries in the shaded area within the red box in Fig. 1 and in Fig. 1: Bhutan, Nepal, Bangladesh, Viet Nam, Dominican Republic, Jamaica, Lao People’s Democratic Republic, Senegal, Philippines, Honduras, Thailand, El Salvador, Mali, Nicaragua, Cambodia, Costa Rica, Nigeria, Ethiopia, Panama, Sierra Leone, Côte d’Ivoire, Togo, Colombia, Central African Republic, Cameroon, Uganda). l. On the other hand, nine countries of Southern Hemisphere (Ecuador, Kenya, Rwanda, Democratic Republic of the Congo, United Republic of Tanzania, Indonesia, Angola, Madagascar, Mozambique) should opt for the vaccine targeted for the Northern Hemisphere (shaded area within the blue box in Fig. 2, Fig.1 and S1 Table). These ‘out-of-phase’ recommendations represent 62% and 53% of countries in the tropical belt of the Northern and Southern Hemisphere. In other words, most countries in this region should receive the vaccine initially recommended for the opposite hemisphere. A few countries with their capital located outside tropical belt (Bhutan, Nepal and Bangladesh in the Northern Hemisphere and Mozambique in the Southern Hemisphere) should also opt for the vaccine for the opposite hemisphere.


A global map of hemispheric influenza vaccine recommendations based on local patterns of viral circulation.

Alonso WJ, Yu C, Viboud C, Richard SA, Schuck-Paim C, Simonsen L, Mello WA, Miller MA - Sci Rep (2015)

Optimal influenza vaccine recommendations for 125 countries contributing surveillance data (NH: Northern Hemisphere; SH: Southern Hemisphere).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664865&req=5

f2: Optimal influenza vaccine recommendations for 125 countries contributing surveillance data (NH: Northern Hemisphere; SH: Southern Hemisphere).
Mentions: Based on the estimated timing of the peak influenza activity, we classified all countries with respect to the vaccine they should adopt (Figs. 1, 2, S1 Table). In total, 26 countries of the Northern Hemisphere should opt for the vaccination recommendation currently targeted at Southern Hemisphere countries (the countries in the shaded area within the red box in Fig. 1 and in Fig. 1: Bhutan, Nepal, Bangladesh, Viet Nam, Dominican Republic, Jamaica, Lao People’s Democratic Republic, Senegal, Philippines, Honduras, Thailand, El Salvador, Mali, Nicaragua, Cambodia, Costa Rica, Nigeria, Ethiopia, Panama, Sierra Leone, Côte d’Ivoire, Togo, Colombia, Central African Republic, Cameroon, Uganda). l. On the other hand, nine countries of Southern Hemisphere (Ecuador, Kenya, Rwanda, Democratic Republic of the Congo, United Republic of Tanzania, Indonesia, Angola, Madagascar, Mozambique) should opt for the vaccine targeted for the Northern Hemisphere (shaded area within the blue box in Fig. 2, Fig.1 and S1 Table). These ‘out-of-phase’ recommendations represent 62% and 53% of countries in the tropical belt of the Northern and Southern Hemisphere. In other words, most countries in this region should receive the vaccine initially recommended for the opposite hemisphere. A few countries with their capital located outside tropical belt (Bhutan, Nepal and Bangladesh in the Northern Hemisphere and Mozambique in the Southern Hemisphere) should also opt for the vaccine for the opposite hemisphere.

Bottom Line: Both the Northern and the Southern Hemisphere annual WHO influenza vaccine recommendations are designed to ensure vaccine delivery before the winter-time peak of viral circulation in each hemisphere.Influenza vaccine recommendations for respectively 25% and 39% of the Northern and Southern Hemisphere countries were out of phase with peak influenza circulation in their corresponding hemisphere (62% and 53%, respectively, when the analysis was limited to the 52 countries in the tropical belt).These results indicate that routine influenza immunization efforts should be closely tailored to local patterns of viral circulation, rather than a country's hemispheric position.

View Article: PubMed Central - PubMed

Affiliation: National Institutes of Health, Fogarty International Center, Bethesda, MD, 20892, USA.

ABSTRACT
Both the Northern and the Southern Hemisphere annual WHO influenza vaccine recommendations are designed to ensure vaccine delivery before the winter-time peak of viral circulation in each hemisphere. However, influenza seasonal patterns are highly diverse in tropical countries and may be out of phase with the WHO recommendations for their respective hemisphere. We modelled the peak timing of influenza activity for 125 countries using laboratory-based surveillance data from the WHO's FLUNET database and compared it with the influenza hemispheric recommendations in place. Influenza vaccine recommendations for respectively 25% and 39% of the Northern and Southern Hemisphere countries were out of phase with peak influenza circulation in their corresponding hemisphere (62% and 53%, respectively, when the analysis was limited to the 52 countries in the tropical belt). These results indicate that routine influenza immunization efforts should be closely tailored to local patterns of viral circulation, rather than a country's hemispheric position.

No MeSH data available.


Related in: MedlinePlus