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Bilateral hippocampal stroke secondary to acute cocaine intoxication.

Connelly KL, Chen X, Kwan PF - Oxf Med Case Reports (2015)

Bottom Line: Subsequent MRI brain revealed high FLAIR signals and diffusion restriction in the hippocampus and centrum semiovale bilaterally, consistent with infarction.These findings were in keeping with the results of formal neuropsychological testing where deficits in both verbal and visual episodic memory and learning capacity were identified, consistent with hippocampal dysfunction.In contrast to previous reports, this presentation occurred in the absence of other vascular risk factors or hypoxic insults.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Medicine , Alfred Health , Melbourne, VIC , Australia.

ABSTRACT
Hippocampal infarction is a rare complication of cocaine use, with only two cases previously reporting this association. We present a 44-year-old male who developed a persistent amnesic syndrome following cocaine intoxication. Examination identified no other neurological deficits. Subsequent MRI brain revealed high FLAIR signals and diffusion restriction in the hippocampus and centrum semiovale bilaterally, consistent with infarction. These findings were in keeping with the results of formal neuropsychological testing where deficits in both verbal and visual episodic memory and learning capacity were identified, consistent with hippocampal dysfunction. In contrast to previous reports, this presentation occurred in the absence of other vascular risk factors or hypoxic insults.

No MeSH data available.


Related in: MedlinePlus

MRI brain—bilateral centrum semiovale infarcts. Corresponding abnormalities in the centrum semiovale bilaterally consistent with acute infarction.
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OMV016F2: MRI brain—bilateral centrum semiovale infarcts. Corresponding abnormalities in the centrum semiovale bilaterally consistent with acute infarction.

Mentions: Given the patient's persistent cognitive deficits, further neuroimaging with MRI was performed on Day 8 of admission. This revealed high T2/FLAIR abnormality with restricted diffusion in hippocampus (Fig. 1) and centrum semiovale (Fig. 2) bilaterally, in keeping with acute infarction. Stroke work-up including ECG monitoring, fasting glucose and lipids, carotid ultrasound and transthoracic echocardiogram returned normal.Figure 1:


Bilateral hippocampal stroke secondary to acute cocaine intoxication.

Connelly KL, Chen X, Kwan PF - Oxf Med Case Reports (2015)

MRI brain—bilateral centrum semiovale infarcts. Corresponding abnormalities in the centrum semiovale bilaterally consistent with acute infarction.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664851&req=5

OMV016F2: MRI brain—bilateral centrum semiovale infarcts. Corresponding abnormalities in the centrum semiovale bilaterally consistent with acute infarction.
Mentions: Given the patient's persistent cognitive deficits, further neuroimaging with MRI was performed on Day 8 of admission. This revealed high T2/FLAIR abnormality with restricted diffusion in hippocampus (Fig. 1) and centrum semiovale (Fig. 2) bilaterally, in keeping with acute infarction. Stroke work-up including ECG monitoring, fasting glucose and lipids, carotid ultrasound and transthoracic echocardiogram returned normal.Figure 1:

Bottom Line: Subsequent MRI brain revealed high FLAIR signals and diffusion restriction in the hippocampus and centrum semiovale bilaterally, consistent with infarction.These findings were in keeping with the results of formal neuropsychological testing where deficits in both verbal and visual episodic memory and learning capacity were identified, consistent with hippocampal dysfunction.In contrast to previous reports, this presentation occurred in the absence of other vascular risk factors or hypoxic insults.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Medicine , Alfred Health , Melbourne, VIC , Australia.

ABSTRACT
Hippocampal infarction is a rare complication of cocaine use, with only two cases previously reporting this association. We present a 44-year-old male who developed a persistent amnesic syndrome following cocaine intoxication. Examination identified no other neurological deficits. Subsequent MRI brain revealed high FLAIR signals and diffusion restriction in the hippocampus and centrum semiovale bilaterally, consistent with infarction. These findings were in keeping with the results of formal neuropsychological testing where deficits in both verbal and visual episodic memory and learning capacity were identified, consistent with hippocampal dysfunction. In contrast to previous reports, this presentation occurred in the absence of other vascular risk factors or hypoxic insults.

No MeSH data available.


Related in: MedlinePlus