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The Role of MicroRNAs in the Regulation of K(+) Channels in Epithelial Tissue.

Pilmore E, Hamilton KL - Front Physiol (2015)

Bottom Line: MiRs are now in the "limelight" as these non-coding pieces of RNA (generally ~22 nucleotides long) result in altered translation and function of proteins.Interestingly, the role of miRs in modulating K(+) channels of epithelial tissues is only emerging now.This minireview focuses on recent novel findings into the role of miRs in the regulation of K(+) channels of epithelia.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, Otago School of Medical Sciences, University of Otago Dunedin, New Zealand.

ABSTRACT
Our understanding of the modulation of proteins has shifted in direction with the discovery of microRNAs (miRs) over twenty years ago. MiRs are now in the "limelight" as these non-coding pieces of RNA (generally ~22 nucleotides long) result in altered translation and function of proteins. Indeed, miRs are now reported to be potential biomarkers of disease. Epithelial K(+) channels play many roles in electrolyte and fluid homeostasis of the human body and have been suggested to be therapeutic targets of disease. Interestingly, the role of miRs in modulating K(+) channels of epithelial tissues is only emerging now. This minireview focuses on recent novel findings into the role of miRs in the regulation of K(+) channels of epithelia.

No MeSH data available.


Related in: MedlinePlus

Transcription of miRNA from DNA. Pri-miRNA is transcribed from DNA by the enzyme RNA polymerase II. The pri-miRNA is recognized by DGCR8 that associates with Drosha which cleaves the pri-miRNA to form a pre-miRNA, The pre-miRNA exits the nucleus via exportin 5. Finally, the pre-miRNA is cleaved by Dicer into mature miRNA. The mature miRNA can then bind either perfectly or imperfectly to its target mRNA. DGCR8, DiGeorge syndrome critical region 8.
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Figure 1: Transcription of miRNA from DNA. Pri-miRNA is transcribed from DNA by the enzyme RNA polymerase II. The pri-miRNA is recognized by DGCR8 that associates with Drosha which cleaves the pri-miRNA to form a pre-miRNA, The pre-miRNA exits the nucleus via exportin 5. Finally, the pre-miRNA is cleaved by Dicer into mature miRNA. The mature miRNA can then bind either perfectly or imperfectly to its target mRNA. DGCR8, DiGeorge syndrome critical region 8.

Mentions: MiRs are transcribed in the nucleus of cells from DNA. The enzyme RNA polymerase II (RNase II) transcribes DNA into a primary RNA (pri-miRNA) within the nucleus. The pri-miRNA is recognized by the nuclear protein DiGeorge syndrome critical region 8 (DGCR8) that associates with Drosha, a RNase III, which cleaves the pri-miRNA generating a precursor miR-RNA (pre-miRNA) (Figure 1). The pre-miRNA then exits the nucleus via a nuclear pore with the assistance of Exportin 5 (Yi et al., 2003). Finally, the pre-miRNA is cleaved by the enzyme Dicer, resulting in the mature miRNA (Figure 1) (Filipowicz et al., 2005).


The Role of MicroRNAs in the Regulation of K(+) Channels in Epithelial Tissue.

Pilmore E, Hamilton KL - Front Physiol (2015)

Transcription of miRNA from DNA. Pri-miRNA is transcribed from DNA by the enzyme RNA polymerase II. The pri-miRNA is recognized by DGCR8 that associates with Drosha which cleaves the pri-miRNA to form a pre-miRNA, The pre-miRNA exits the nucleus via exportin 5. Finally, the pre-miRNA is cleaved by Dicer into mature miRNA. The mature miRNA can then bind either perfectly or imperfectly to its target mRNA. DGCR8, DiGeorge syndrome critical region 8.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664832&req=5

Figure 1: Transcription of miRNA from DNA. Pri-miRNA is transcribed from DNA by the enzyme RNA polymerase II. The pri-miRNA is recognized by DGCR8 that associates with Drosha which cleaves the pri-miRNA to form a pre-miRNA, The pre-miRNA exits the nucleus via exportin 5. Finally, the pre-miRNA is cleaved by Dicer into mature miRNA. The mature miRNA can then bind either perfectly or imperfectly to its target mRNA. DGCR8, DiGeorge syndrome critical region 8.
Mentions: MiRs are transcribed in the nucleus of cells from DNA. The enzyme RNA polymerase II (RNase II) transcribes DNA into a primary RNA (pri-miRNA) within the nucleus. The pri-miRNA is recognized by the nuclear protein DiGeorge syndrome critical region 8 (DGCR8) that associates with Drosha, a RNase III, which cleaves the pri-miRNA generating a precursor miR-RNA (pre-miRNA) (Figure 1). The pre-miRNA then exits the nucleus via a nuclear pore with the assistance of Exportin 5 (Yi et al., 2003). Finally, the pre-miRNA is cleaved by the enzyme Dicer, resulting in the mature miRNA (Figure 1) (Filipowicz et al., 2005).

Bottom Line: MiRs are now in the "limelight" as these non-coding pieces of RNA (generally ~22 nucleotides long) result in altered translation and function of proteins.Interestingly, the role of miRs in modulating K(+) channels of epithelial tissues is only emerging now.This minireview focuses on recent novel findings into the role of miRs in the regulation of K(+) channels of epithelia.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, Otago School of Medical Sciences, University of Otago Dunedin, New Zealand.

ABSTRACT
Our understanding of the modulation of proteins has shifted in direction with the discovery of microRNAs (miRs) over twenty years ago. MiRs are now in the "limelight" as these non-coding pieces of RNA (generally ~22 nucleotides long) result in altered translation and function of proteins. Indeed, miRs are now reported to be potential biomarkers of disease. Epithelial K(+) channels play many roles in electrolyte and fluid homeostasis of the human body and have been suggested to be therapeutic targets of disease. Interestingly, the role of miRs in modulating K(+) channels of epithelial tissues is only emerging now. This minireview focuses on recent novel findings into the role of miRs in the regulation of K(+) channels of epithelia.

No MeSH data available.


Related in: MedlinePlus