Limits...
Improvement in Paretic Arm Reach-to-Grasp following Low Frequency Repetitive Transcranial Magnetic Stimulation Depends on Object Size: A Pilot Study.

Tretriluxana J, Kantak S, Tretriluxana S, Wu AD, Fisher BE - Stroke Res Treat (2015)

Bottom Line: Compared to sham rTMS, real rTMS significantly reduced CE of the non-lesioned M1.While rTMS had no effect on RTG action for the larger object, real rTMS significantly improved movement time, aperture opening, and RTG coordination for the smaller object.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Physical Therapy, Mahidol University, Nakhon Pathom 73170, Thailand.

ABSTRACT
Introduction. Low frequency repetitive transcranial magnetic stimulation (LF-rTMS) delivered to the nonlesioned hemisphere has been shown to improve limited function of the paretic upper extremity (UE) following stroke. The outcome measures have largely included clinical assessments with little investigation on changes in kinematics and coordination. To date, there is no study investigating how the effects of LF-rTMS are modulated by the sizes of an object to be grasped. Objective. To investigate the effect of LF-rTMS on kinematics and coordination of the paretic hand reach-to-grasp (RTG) for two object sizes in chronic stroke. Methods. Nine participants received two TMS conditions: real rTMS and sham rTMS conditions. Before and after the rTMS conditions, cortico-motor excitability (CE) of the nonlesioned hemisphere, RTG kinematics, and coordination was evaluated. Object sizes were 1.2 and 7.2 cm in diameter. Results. Compared to sham rTMS, real rTMS significantly reduced CE of the non-lesioned M1. While rTMS had no effect on RTG action for the larger object, real rTMS significantly improved movement time, aperture opening, and RTG coordination for the smaller object. Conclusions. LF-rTMS improves RTG action for only the smaller object in chronic stroke. The findings suggest a dissociation between effects of rTMS on M1 and task difficulty for this complex skill.

No MeSH data available.


Related in: MedlinePlus

Reach-to-grasp coordination for the small object (left) and the large object (right) pre (●) and post (○) each TMS condition. (a) Highest cross-correlation coefficient. (b) Associated time lag. ∗ indicates a significant interaction between the TMS condition and time. † indicates a significant difference before compared to after TMS conditions.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4664821&req=5

fig6: Reach-to-grasp coordination for the small object (left) and the large object (right) pre (●) and post (○) each TMS condition. (a) Highest cross-correlation coefficient. (b) Associated time lag. ∗ indicates a significant interaction between the TMS condition and time. † indicates a significant difference before compared to after TMS conditions.

Mentions: All measures of RTG kinematics and RTG coordination of both large and small objects are shown in Figures 2–6.


Improvement in Paretic Arm Reach-to-Grasp following Low Frequency Repetitive Transcranial Magnetic Stimulation Depends on Object Size: A Pilot Study.

Tretriluxana J, Kantak S, Tretriluxana S, Wu AD, Fisher BE - Stroke Res Treat (2015)

Reach-to-grasp coordination for the small object (left) and the large object (right) pre (●) and post (○) each TMS condition. (a) Highest cross-correlation coefficient. (b) Associated time lag. ∗ indicates a significant interaction between the TMS condition and time. † indicates a significant difference before compared to after TMS conditions.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4664821&req=5

fig6: Reach-to-grasp coordination for the small object (left) and the large object (right) pre (●) and post (○) each TMS condition. (a) Highest cross-correlation coefficient. (b) Associated time lag. ∗ indicates a significant interaction between the TMS condition and time. † indicates a significant difference before compared to after TMS conditions.
Mentions: All measures of RTG kinematics and RTG coordination of both large and small objects are shown in Figures 2–6.

Bottom Line: Compared to sham rTMS, real rTMS significantly reduced CE of the non-lesioned M1.While rTMS had no effect on RTG action for the larger object, real rTMS significantly improved movement time, aperture opening, and RTG coordination for the smaller object.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Physical Therapy, Mahidol University, Nakhon Pathom 73170, Thailand.

ABSTRACT
Introduction. Low frequency repetitive transcranial magnetic stimulation (LF-rTMS) delivered to the nonlesioned hemisphere has been shown to improve limited function of the paretic upper extremity (UE) following stroke. The outcome measures have largely included clinical assessments with little investigation on changes in kinematics and coordination. To date, there is no study investigating how the effects of LF-rTMS are modulated by the sizes of an object to be grasped. Objective. To investigate the effect of LF-rTMS on kinematics and coordination of the paretic hand reach-to-grasp (RTG) for two object sizes in chronic stroke. Methods. Nine participants received two TMS conditions: real rTMS and sham rTMS conditions. Before and after the rTMS conditions, cortico-motor excitability (CE) of the nonlesioned hemisphere, RTG kinematics, and coordination was evaluated. Object sizes were 1.2 and 7.2 cm in diameter. Results. Compared to sham rTMS, real rTMS significantly reduced CE of the non-lesioned M1. While rTMS had no effect on RTG action for the larger object, real rTMS significantly improved movement time, aperture opening, and RTG coordination for the smaller object. Conclusions. LF-rTMS improves RTG action for only the smaller object in chronic stroke. The findings suggest a dissociation between effects of rTMS on M1 and task difficulty for this complex skill.

No MeSH data available.


Related in: MedlinePlus