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Small Molecules from Nature Targeting G-Protein Coupled Cannabinoid Receptors: Potential Leads for Drug Discovery and Development.

Sharma C, Sadek B, Goyal SN, Sinha S, Kamal MA, Ojha S - Evid Based Complement Alternat Med (2015)

Bottom Line: This encourages us to find out an alternative and safe drug with the least psychiatric adverse effects.Also, these naturally derived molecules possess the least adverse effects opposed to the synthetically derived cannabinoids.The present review provides an overview of therapeutic potential of ligands and plants modulating cannabinoid receptors that may be of interest to pharmaceutical industry in search of new and safer drug discovery and development for future therapeutics.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, Abu Dhabi, UAE.

ABSTRACT
The cannabinoid molecules are derived from Cannabis sativa plant which acts on the cannabinoid receptors types 1 and 2 (CB1 and CB2) which have been explored as potential therapeutic targets for drug discovery and development. Currently, there are numerous cannabinoid based synthetic drugs used in clinical practice like the popular ones such as nabilone, dronabinol, and Δ(9)-tetrahydrocannabinol mediates its action through CB1/CB2 receptors. However, these synthetic based Cannabis derived compounds are known to exert adverse psychiatric effect and have also been exploited for drug abuse. This encourages us to find out an alternative and safe drug with the least psychiatric adverse effects. In recent years, many phytocannabinoids have been isolated from plants other than Cannabis. Several studies have shown that these phytocannabinoids show affinity, potency, selectivity, and efficacy towards cannabinoid receptors and inhibit endocannabinoid metabolizing enzymes, thus reducing hyperactivity of endocannabinoid systems. Also, these naturally derived molecules possess the least adverse effects opposed to the synthetically derived cannabinoids. Therefore, the plant based cannabinoid molecules proved to be promising and emerging therapeutic alternative. The present review provides an overview of therapeutic potential of ligands and plants modulating cannabinoid receptors that may be of interest to pharmaceutical industry in search of new and safer drug discovery and development for future therapeutics.

No MeSH data available.


Related in: MedlinePlus

Chemical structure of isolated phytochemicals targeting endocannabinoid system.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4664820&req=5

fig2: Chemical structure of isolated phytochemicals targeting endocannabinoid system.

Mentions: Table 1 depicts the physicochemical properties and drug likeness of phytochemicals and Figure 2 represents the chemical structure of phytochemicals modulating cannabinoid receptors and endocannabinoid metabolizing enzymes. Table 2 shows the therapeutic properties and underlying cannabinoid mediated mechanism of small natural molecules modulating cannabinoid receptors and endocannabinoid metabolizing enzymes. The cannabinoids are chemically defined as terpenoalcoholic compounds and chemical class of molecules identified till date is provided in Table 3. Recently, some selective full agonists and antagonists for specific CB1 and CB2 receptors have been recognized. Among the phytocannabinoids, β-caryophyllene is one which has been identified as a full agonist for CB2 receptors and isolated from cannabis as well as noncannabis plant [18]. This generated interest in characterizing the cannabinoid-like compounds or CB receptor modulating ligands from plants other than cannabis, which is considered a traditional source of phytocannabinoids.


Small Molecules from Nature Targeting G-Protein Coupled Cannabinoid Receptors: Potential Leads for Drug Discovery and Development.

Sharma C, Sadek B, Goyal SN, Sinha S, Kamal MA, Ojha S - Evid Based Complement Alternat Med (2015)

Chemical structure of isolated phytochemicals targeting endocannabinoid system.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4664820&req=5

fig2: Chemical structure of isolated phytochemicals targeting endocannabinoid system.
Mentions: Table 1 depicts the physicochemical properties and drug likeness of phytochemicals and Figure 2 represents the chemical structure of phytochemicals modulating cannabinoid receptors and endocannabinoid metabolizing enzymes. Table 2 shows the therapeutic properties and underlying cannabinoid mediated mechanism of small natural molecules modulating cannabinoid receptors and endocannabinoid metabolizing enzymes. The cannabinoids are chemically defined as terpenoalcoholic compounds and chemical class of molecules identified till date is provided in Table 3. Recently, some selective full agonists and antagonists for specific CB1 and CB2 receptors have been recognized. Among the phytocannabinoids, β-caryophyllene is one which has been identified as a full agonist for CB2 receptors and isolated from cannabis as well as noncannabis plant [18]. This generated interest in characterizing the cannabinoid-like compounds or CB receptor modulating ligands from plants other than cannabis, which is considered a traditional source of phytocannabinoids.

Bottom Line: This encourages us to find out an alternative and safe drug with the least psychiatric adverse effects.Also, these naturally derived molecules possess the least adverse effects opposed to the synthetically derived cannabinoids.The present review provides an overview of therapeutic potential of ligands and plants modulating cannabinoid receptors that may be of interest to pharmaceutical industry in search of new and safer drug discovery and development for future therapeutics.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, Abu Dhabi, UAE.

ABSTRACT
The cannabinoid molecules are derived from Cannabis sativa plant which acts on the cannabinoid receptors types 1 and 2 (CB1 and CB2) which have been explored as potential therapeutic targets for drug discovery and development. Currently, there are numerous cannabinoid based synthetic drugs used in clinical practice like the popular ones such as nabilone, dronabinol, and Δ(9)-tetrahydrocannabinol mediates its action through CB1/CB2 receptors. However, these synthetic based Cannabis derived compounds are known to exert adverse psychiatric effect and have also been exploited for drug abuse. This encourages us to find out an alternative and safe drug with the least psychiatric adverse effects. In recent years, many phytocannabinoids have been isolated from plants other than Cannabis. Several studies have shown that these phytocannabinoids show affinity, potency, selectivity, and efficacy towards cannabinoid receptors and inhibit endocannabinoid metabolizing enzymes, thus reducing hyperactivity of endocannabinoid systems. Also, these naturally derived molecules possess the least adverse effects opposed to the synthetically derived cannabinoids. Therefore, the plant based cannabinoid molecules proved to be promising and emerging therapeutic alternative. The present review provides an overview of therapeutic potential of ligands and plants modulating cannabinoid receptors that may be of interest to pharmaceutical industry in search of new and safer drug discovery and development for future therapeutics.

No MeSH data available.


Related in: MedlinePlus