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Small Molecules from Nature Targeting G-Protein Coupled Cannabinoid Receptors: Potential Leads for Drug Discovery and Development.

Sharma C, Sadek B, Goyal SN, Sinha S, Kamal MA, Ojha S - Evid Based Complement Alternat Med (2015)

Bottom Line: This encourages us to find out an alternative and safe drug with the least psychiatric adverse effects.Also, these naturally derived molecules possess the least adverse effects opposed to the synthetically derived cannabinoids.The present review provides an overview of therapeutic potential of ligands and plants modulating cannabinoid receptors that may be of interest to pharmaceutical industry in search of new and safer drug discovery and development for future therapeutics.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, Abu Dhabi, UAE.

ABSTRACT
The cannabinoid molecules are derived from Cannabis sativa plant which acts on the cannabinoid receptors types 1 and 2 (CB1 and CB2) which have been explored as potential therapeutic targets for drug discovery and development. Currently, there are numerous cannabinoid based synthetic drugs used in clinical practice like the popular ones such as nabilone, dronabinol, and Δ(9)-tetrahydrocannabinol mediates its action through CB1/CB2 receptors. However, these synthetic based Cannabis derived compounds are known to exert adverse psychiatric effect and have also been exploited for drug abuse. This encourages us to find out an alternative and safe drug with the least psychiatric adverse effects. In recent years, many phytocannabinoids have been isolated from plants other than Cannabis. Several studies have shown that these phytocannabinoids show affinity, potency, selectivity, and efficacy towards cannabinoid receptors and inhibit endocannabinoid metabolizing enzymes, thus reducing hyperactivity of endocannabinoid systems. Also, these naturally derived molecules possess the least adverse effects opposed to the synthetically derived cannabinoids. Therefore, the plant based cannabinoid molecules proved to be promising and emerging therapeutic alternative. The present review provides an overview of therapeutic potential of ligands and plants modulating cannabinoid receptors that may be of interest to pharmaceutical industry in search of new and safer drug discovery and development for future therapeutics.

No MeSH data available.


Related in: MedlinePlus

Cannabinoid receptor mediated medicinal and pharmacological activities of lead compounds isolated from medicinal plants.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4664820&req=5

fig1: Cannabinoid receptor mediated medicinal and pharmacological activities of lead compounds isolated from medicinal plants.

Mentions: Following the progress in chemical isolation and screening techniques, several novel lead molecules were isolated and characterized from the natural products for the development of new drugs. In current years, numerous molecules have been isolated and characterized which showed cannabinoid receptor affinity, efficacy, and therapeutic benefits in the in vitro, in silico, and in vivo studies [15–21]. The agents were also found to inhibit endocannabinoid metabolizing enzymes, FAAH, DAGL, and MAGL inhibitors, and exhibit their potential efficacy mediated by the cannabinoid mediated mechanism [7]. Figure 1 depicts the cannabinoid receptors and endocannabinoid metabolizing enzymes mediated pharmacological effects and therapeutic benefits of small molecules derived from nature.


Small Molecules from Nature Targeting G-Protein Coupled Cannabinoid Receptors: Potential Leads for Drug Discovery and Development.

Sharma C, Sadek B, Goyal SN, Sinha S, Kamal MA, Ojha S - Evid Based Complement Alternat Med (2015)

Cannabinoid receptor mediated medicinal and pharmacological activities of lead compounds isolated from medicinal plants.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4664820&req=5

fig1: Cannabinoid receptor mediated medicinal and pharmacological activities of lead compounds isolated from medicinal plants.
Mentions: Following the progress in chemical isolation and screening techniques, several novel lead molecules were isolated and characterized from the natural products for the development of new drugs. In current years, numerous molecules have been isolated and characterized which showed cannabinoid receptor affinity, efficacy, and therapeutic benefits in the in vitro, in silico, and in vivo studies [15–21]. The agents were also found to inhibit endocannabinoid metabolizing enzymes, FAAH, DAGL, and MAGL inhibitors, and exhibit their potential efficacy mediated by the cannabinoid mediated mechanism [7]. Figure 1 depicts the cannabinoid receptors and endocannabinoid metabolizing enzymes mediated pharmacological effects and therapeutic benefits of small molecules derived from nature.

Bottom Line: This encourages us to find out an alternative and safe drug with the least psychiatric adverse effects.Also, these naturally derived molecules possess the least adverse effects opposed to the synthetically derived cannabinoids.The present review provides an overview of therapeutic potential of ligands and plants modulating cannabinoid receptors that may be of interest to pharmaceutical industry in search of new and safer drug discovery and development for future therapeutics.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, Abu Dhabi, UAE.

ABSTRACT
The cannabinoid molecules are derived from Cannabis sativa plant which acts on the cannabinoid receptors types 1 and 2 (CB1 and CB2) which have been explored as potential therapeutic targets for drug discovery and development. Currently, there are numerous cannabinoid based synthetic drugs used in clinical practice like the popular ones such as nabilone, dronabinol, and Δ(9)-tetrahydrocannabinol mediates its action through CB1/CB2 receptors. However, these synthetic based Cannabis derived compounds are known to exert adverse psychiatric effect and have also been exploited for drug abuse. This encourages us to find out an alternative and safe drug with the least psychiatric adverse effects. In recent years, many phytocannabinoids have been isolated from plants other than Cannabis. Several studies have shown that these phytocannabinoids show affinity, potency, selectivity, and efficacy towards cannabinoid receptors and inhibit endocannabinoid metabolizing enzymes, thus reducing hyperactivity of endocannabinoid systems. Also, these naturally derived molecules possess the least adverse effects opposed to the synthetically derived cannabinoids. Therefore, the plant based cannabinoid molecules proved to be promising and emerging therapeutic alternative. The present review provides an overview of therapeutic potential of ligands and plants modulating cannabinoid receptors that may be of interest to pharmaceutical industry in search of new and safer drug discovery and development for future therapeutics.

No MeSH data available.


Related in: MedlinePlus