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Hypofractionated radiotherapy versus conventionally fractionated radiotherapy for patients with intermediate-risk localised prostate cancer: 2-year patient-reported outcomes of the randomised, non-inferiority, phase 3 CHHiP trial.

Wilkins A, Mossop H, Syndikus I, Khoo V, Bloomfield D, Parker C, Logue J, Scrase C, Patterson H, Birtle A, Staffurth J, Malik Z, Panades M, Eswar C, Graham J, Russell M, Kirkbride P, O'Sullivan JM, Gao A, Cruickshank C, Griffin C, Dearnaley D, Hall E - Lancet Oncol. (2015)

Bottom Line: Treatment allocation was not masked.Comparison of 74 Gy in 37 fractions, 60 Gy in 20 fractions, and 57 Gy in 19 fractions groups at 2 years showed no overall bowel bother in 269 (66%), 266 (65%), and 282 (65%) men; very small bother in 92 (22%), 91 (22%), and 93 (21%) men; small bother in 26 (6%), 28 (7%), and 38 (9%) men; moderate bother in 19 (5%), 23 (6%), and 21 (5%) men, and severe bother in four (<1%), three (<1%) and three (<1%) men respectively (74 Gy vs 60 Gy, ptrend=0.64, 74 Gy vs 57 Gy, ptrend=0·59).We saw no differences between treatment groups in change of bowel bother score from baseline or pre-radiotherapy to 24 months.

View Article: PubMed Central - PubMed

Affiliation: The Institute of Cancer Research, London, UK.

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Overall bowel, urinary, and sexual botherData are prevalence of overall bowel bother (A), time to small or worse overall bowel bother (B), prevalence of overall urinary bother (C), time to small or worse overall urinary bother (D), prevalence of overall sexual bother (E), and time to small or worse overall sexual bother (F).
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fig2: Overall bowel, urinary, and sexual botherData are prevalence of overall bowel bother (A), time to small or worse overall bowel bother (B), prevalence of overall urinary bother (C), time to small or worse overall urinary bother (D), prevalence of overall sexual bother (E), and time to small or worse overall sexual bother (F).

Mentions: The incidence of overall bowel bother was low (figure 2, appendix p 3). At 24 months post-radiotherapy, we recorded no overall bowel bother for 269 (66%) of 410 men treated with 74 Gy, 266 (65%) of 411 men treated with 60 Gy, and 282 (65%) of 437 men treated with 57 Gy; very small bother for 92 (22%), 91 (22%), and 93 (21%) men; small bother for 26 (6%), 28 (7%), and 38 (9%) men; moderate bother for 19 (5%), 23 (6%), 21 (5%) men; and severe bother for four (<1%), three (<1%), and three (<1%) men, respectively. Cross-sectional analysis at 24 months showed no significant differences in overall bowel bother between the treatment groups (74 Gy vs 60 Gy, ptrend=0·64; 74 Gy vs 57 Gy, ptrend=0·59; appendix p 3).


Hypofractionated radiotherapy versus conventionally fractionated radiotherapy for patients with intermediate-risk localised prostate cancer: 2-year patient-reported outcomes of the randomised, non-inferiority, phase 3 CHHiP trial.

Wilkins A, Mossop H, Syndikus I, Khoo V, Bloomfield D, Parker C, Logue J, Scrase C, Patterson H, Birtle A, Staffurth J, Malik Z, Panades M, Eswar C, Graham J, Russell M, Kirkbride P, O'Sullivan JM, Gao A, Cruickshank C, Griffin C, Dearnaley D, Hall E - Lancet Oncol. (2015)

Overall bowel, urinary, and sexual botherData are prevalence of overall bowel bother (A), time to small or worse overall bowel bother (B), prevalence of overall urinary bother (C), time to small or worse overall urinary bother (D), prevalence of overall sexual bother (E), and time to small or worse overall sexual bother (F).
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664817&req=5

fig2: Overall bowel, urinary, and sexual botherData are prevalence of overall bowel bother (A), time to small or worse overall bowel bother (B), prevalence of overall urinary bother (C), time to small or worse overall urinary bother (D), prevalence of overall sexual bother (E), and time to small or worse overall sexual bother (F).
Mentions: The incidence of overall bowel bother was low (figure 2, appendix p 3). At 24 months post-radiotherapy, we recorded no overall bowel bother for 269 (66%) of 410 men treated with 74 Gy, 266 (65%) of 411 men treated with 60 Gy, and 282 (65%) of 437 men treated with 57 Gy; very small bother for 92 (22%), 91 (22%), and 93 (21%) men; small bother for 26 (6%), 28 (7%), and 38 (9%) men; moderate bother for 19 (5%), 23 (6%), 21 (5%) men; and severe bother for four (<1%), three (<1%), and three (<1%) men, respectively. Cross-sectional analysis at 24 months showed no significant differences in overall bowel bother between the treatment groups (74 Gy vs 60 Gy, ptrend=0·64; 74 Gy vs 57 Gy, ptrend=0·59; appendix p 3).

Bottom Line: Treatment allocation was not masked.Comparison of 74 Gy in 37 fractions, 60 Gy in 20 fractions, and 57 Gy in 19 fractions groups at 2 years showed no overall bowel bother in 269 (66%), 266 (65%), and 282 (65%) men; very small bother in 92 (22%), 91 (22%), and 93 (21%) men; small bother in 26 (6%), 28 (7%), and 38 (9%) men; moderate bother in 19 (5%), 23 (6%), and 21 (5%) men, and severe bother in four (<1%), three (<1%) and three (<1%) men respectively (74 Gy vs 60 Gy, ptrend=0.64, 74 Gy vs 57 Gy, ptrend=0·59).We saw no differences between treatment groups in change of bowel bother score from baseline or pre-radiotherapy to 24 months.

View Article: PubMed Central - PubMed

Affiliation: The Institute of Cancer Research, London, UK.

Show MeSH
Related in: MedlinePlus