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Correlation of Vitreous Vascular Endothelial Growth Factor and Uric Acid Concentration Using Optical Coherence Tomography in Diabetic Macular Edema.

Krizova L, Kalousova M, Kubena AA, Chrapek O, Chrapkova B, Sin M, Zima T - J Ophthalmol (2015)

Bottom Line: Conclusions.The results suggest that the CV might be assessor of anti-VEGF therapy efficacy.Second, apart from VEGF, the role of UA in the pathogenesis and progression of DR should be considered.

View Article: PubMed Central - PubMed

Affiliation: Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital, U Nemocnice 2, 128 08 Prague 2, Czech Republic ; Augenzentrum Augsburg, Prinzregentenstraße 25, 86150 Augsburg, Germany.

ABSTRACT
Purpose. We investigated two factors linked to diabetic macular edema (DME), vitreous and serum levels of vascular endothelial growth factor (VEGF) and uric acid (UA) in patients with DME, and compared the results with changes in optical coherence tomography (OCT) and visual acuity (VA). Methods. A prospective study of 29 eyes, 16 cystoid DME and nonproliferative diabetic retinopathy (DR) and 13 nondiabetic controls. Biochemical analysis of vitreous and serum samples was performed and OCT scans were graded according to central retinal thickness (CRT), cube volume (CV), cube average thickness (CAT), and serous retinal detachment (SRD). Results. In DME group, intravitreal concentrations of VEGF (p < 0.001), UA (p = 0.038), and total protein (p < 0.001) were significantly higher than in control group. In DME subjects, intravitreal UA correlated significantly with intravitreal VEGF (ƍ = 0.559, p = 0.03) but not with total vitreous protein and serum UA. Increased intravitreal VEGF in DME group correlated with increase in CV (ƍ = 0.515/p = 0.041). None of the OCT parameters correlated with the VA. Conclusions. The results suggest that the CV might be assessor of anti-VEGF therapy efficacy. Second, apart from VEGF, the role of UA in the pathogenesis and progression of DR should be considered.

No MeSH data available.


Related in: MedlinePlus

Relationship between vitreous VEGF and vitreous UA concentrations in diabetic versus control group. Dashed lines represent limits of detection (VEGF = 31.2 pg/mL, UA = 30 µmol/L).
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fig4: Relationship between vitreous VEGF and vitreous UA concentrations in diabetic versus control group. Dashed lines represent limits of detection (VEGF = 31.2 pg/mL, UA = 30 µmol/L).

Mentions: In the diabetic group, UA concentration in vitreous correlated significantly with vitreous VEGF concentration (ƍ = 0.559, p = 0.03). However, in DME vitreous VEGF and UA did not correlate with the total vitreous protein. Further, in the control group, no significant correlation between the biochemical analytes in vitreous was found. Figure 4 shows the relationship between vitreous VEGF and vitreous UA of DME and control group.


Correlation of Vitreous Vascular Endothelial Growth Factor and Uric Acid Concentration Using Optical Coherence Tomography in Diabetic Macular Edema.

Krizova L, Kalousova M, Kubena AA, Chrapek O, Chrapkova B, Sin M, Zima T - J Ophthalmol (2015)

Relationship between vitreous VEGF and vitreous UA concentrations in diabetic versus control group. Dashed lines represent limits of detection (VEGF = 31.2 pg/mL, UA = 30 µmol/L).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4664812&req=5

fig4: Relationship between vitreous VEGF and vitreous UA concentrations in diabetic versus control group. Dashed lines represent limits of detection (VEGF = 31.2 pg/mL, UA = 30 µmol/L).
Mentions: In the diabetic group, UA concentration in vitreous correlated significantly with vitreous VEGF concentration (ƍ = 0.559, p = 0.03). However, in DME vitreous VEGF and UA did not correlate with the total vitreous protein. Further, in the control group, no significant correlation between the biochemical analytes in vitreous was found. Figure 4 shows the relationship between vitreous VEGF and vitreous UA of DME and control group.

Bottom Line: Conclusions.The results suggest that the CV might be assessor of anti-VEGF therapy efficacy.Second, apart from VEGF, the role of UA in the pathogenesis and progression of DR should be considered.

View Article: PubMed Central - PubMed

Affiliation: Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital, U Nemocnice 2, 128 08 Prague 2, Czech Republic ; Augenzentrum Augsburg, Prinzregentenstraße 25, 86150 Augsburg, Germany.

ABSTRACT
Purpose. We investigated two factors linked to diabetic macular edema (DME), vitreous and serum levels of vascular endothelial growth factor (VEGF) and uric acid (UA) in patients with DME, and compared the results with changes in optical coherence tomography (OCT) and visual acuity (VA). Methods. A prospective study of 29 eyes, 16 cystoid DME and nonproliferative diabetic retinopathy (DR) and 13 nondiabetic controls. Biochemical analysis of vitreous and serum samples was performed and OCT scans were graded according to central retinal thickness (CRT), cube volume (CV), cube average thickness (CAT), and serous retinal detachment (SRD). Results. In DME group, intravitreal concentrations of VEGF (p < 0.001), UA (p = 0.038), and total protein (p < 0.001) were significantly higher than in control group. In DME subjects, intravitreal UA correlated significantly with intravitreal VEGF (ƍ = 0.559, p = 0.03) but not with total vitreous protein and serum UA. Increased intravitreal VEGF in DME group correlated with increase in CV (ƍ = 0.515/p = 0.041). None of the OCT parameters correlated with the VA. Conclusions. The results suggest that the CV might be assessor of anti-VEGF therapy efficacy. Second, apart from VEGF, the role of UA in the pathogenesis and progression of DR should be considered.

No MeSH data available.


Related in: MedlinePlus