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Correlation of Vitreous Vascular Endothelial Growth Factor and Uric Acid Concentration Using Optical Coherence Tomography in Diabetic Macular Edema.

Krizova L, Kalousova M, Kubena AA, Chrapek O, Chrapkova B, Sin M, Zima T - J Ophthalmol (2015)

Bottom Line: Conclusions.The results suggest that the CV might be assessor of anti-VEGF therapy efficacy.Second, apart from VEGF, the role of UA in the pathogenesis and progression of DR should be considered.

View Article: PubMed Central - PubMed

Affiliation: Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital, U Nemocnice 2, 128 08 Prague 2, Czech Republic ; Augenzentrum Augsburg, Prinzregentenstraße 25, 86150 Augsburg, Germany.

ABSTRACT
Purpose. We investigated two factors linked to diabetic macular edema (DME), vitreous and serum levels of vascular endothelial growth factor (VEGF) and uric acid (UA) in patients with DME, and compared the results with changes in optical coherence tomography (OCT) and visual acuity (VA). Methods. A prospective study of 29 eyes, 16 cystoid DME and nonproliferative diabetic retinopathy (DR) and 13 nondiabetic controls. Biochemical analysis of vitreous and serum samples was performed and OCT scans were graded according to central retinal thickness (CRT), cube volume (CV), cube average thickness (CAT), and serous retinal detachment (SRD). Results. In DME group, intravitreal concentrations of VEGF (p < 0.001), UA (p = 0.038), and total protein (p < 0.001) were significantly higher than in control group. In DME subjects, intravitreal UA correlated significantly with intravitreal VEGF (ƍ = 0.559, p = 0.03) but not with total vitreous protein and serum UA. Increased intravitreal VEGF in DME group correlated with increase in CV (ƍ = 0.515/p = 0.041). None of the OCT parameters correlated with the VA. Conclusions. The results suggest that the CV might be assessor of anti-VEGF therapy efficacy. Second, apart from VEGF, the role of UA in the pathogenesis and progression of DR should be considered.

No MeSH data available.


Related in: MedlinePlus

Vitreous concentrations of total protein in diabetic versus control group. DM group n = 16, control group n = 13, and ∗∗∗p < 0.001 DM versus control patients.
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fig3: Vitreous concentrations of total protein in diabetic versus control group. DM group n = 16, control group n = 13, and ∗∗∗p < 0.001 DM versus control patients.

Mentions: Biochemical analysis of the vitreous showed significant differences between DM and control group in the concentration of VEGF, UA, and total protein but not albumin as shown in Table 2 and Figures 1–3. In all nondiabetic control subjects, the concentration of VEGF in vitreous was under the detection limit of 31.2 pg/mL.


Correlation of Vitreous Vascular Endothelial Growth Factor and Uric Acid Concentration Using Optical Coherence Tomography in Diabetic Macular Edema.

Krizova L, Kalousova M, Kubena AA, Chrapek O, Chrapkova B, Sin M, Zima T - J Ophthalmol (2015)

Vitreous concentrations of total protein in diabetic versus control group. DM group n = 16, control group n = 13, and ∗∗∗p < 0.001 DM versus control patients.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4664812&req=5

fig3: Vitreous concentrations of total protein in diabetic versus control group. DM group n = 16, control group n = 13, and ∗∗∗p < 0.001 DM versus control patients.
Mentions: Biochemical analysis of the vitreous showed significant differences between DM and control group in the concentration of VEGF, UA, and total protein but not albumin as shown in Table 2 and Figures 1–3. In all nondiabetic control subjects, the concentration of VEGF in vitreous was under the detection limit of 31.2 pg/mL.

Bottom Line: Conclusions.The results suggest that the CV might be assessor of anti-VEGF therapy efficacy.Second, apart from VEGF, the role of UA in the pathogenesis and progression of DR should be considered.

View Article: PubMed Central - PubMed

Affiliation: Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital, U Nemocnice 2, 128 08 Prague 2, Czech Republic ; Augenzentrum Augsburg, Prinzregentenstraße 25, 86150 Augsburg, Germany.

ABSTRACT
Purpose. We investigated two factors linked to diabetic macular edema (DME), vitreous and serum levels of vascular endothelial growth factor (VEGF) and uric acid (UA) in patients with DME, and compared the results with changes in optical coherence tomography (OCT) and visual acuity (VA). Methods. A prospective study of 29 eyes, 16 cystoid DME and nonproliferative diabetic retinopathy (DR) and 13 nondiabetic controls. Biochemical analysis of vitreous and serum samples was performed and OCT scans were graded according to central retinal thickness (CRT), cube volume (CV), cube average thickness (CAT), and serous retinal detachment (SRD). Results. In DME group, intravitreal concentrations of VEGF (p < 0.001), UA (p = 0.038), and total protein (p < 0.001) were significantly higher than in control group. In DME subjects, intravitreal UA correlated significantly with intravitreal VEGF (ƍ = 0.559, p = 0.03) but not with total vitreous protein and serum UA. Increased intravitreal VEGF in DME group correlated with increase in CV (ƍ = 0.515/p = 0.041). None of the OCT parameters correlated with the VA. Conclusions. The results suggest that the CV might be assessor of anti-VEGF therapy efficacy. Second, apart from VEGF, the role of UA in the pathogenesis and progression of DR should be considered.

No MeSH data available.


Related in: MedlinePlus