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Carcinosarcoma of the Rectum: Report of a Rare Colorectal Malignancy and Review of the Literature.

Sudlow A, Liu MH, Waters G, Velchuru VR - Case Rep Surg (2015)

Bottom Line: Histologically, it is composed of two distinct elements of epithelial and mesenchymal origin.Prognosis is poor despite intervention with the majority of patients dying within six months.Due to the rarity of this condition, there are no specific treatment guidelines presently available.

View Article: PubMed Central - PubMed

Affiliation: Department of Colorectal Surgery, James Paget University Hospital, Gorleston NR31 6LA, UK.

ABSTRACT
Carcinosarcoma (CS) is a rare mixed mesodermal malignancy most commonly affecting the female reproductive organs, respiratory tract, head, and neck. Though infrequent, it may affect the gastrointestinal tract, most often the oesophagus and only very rarely the rectum. Histologically, it is composed of two distinct elements of epithelial and mesenchymal origin. Clinically, it is a very aggressive tumour with many patients presenting with metastatic lymph nodes or distant metastases at the time of diagnosis. Prognosis is poor despite intervention with the majority of patients dying within six months. Due to the rarity of this condition, there are no specific treatment guidelines presently available. We describe the case of an 80-year-old patient with carcinosarcoma of the rectum with discussion of the immunohistochemistry and review the available literature pertaining to this rare presentation.

No MeSH data available.


Related in: MedlinePlus

Positive staining for desmin in the sarcomatous component.
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fig6: Positive staining for desmin in the sarcomatous component.

Mentions: Given the heterogeneous nature of the tumour, the two components showed distinct immunohistochemistry. The epithelial component stained positively for CK20 (Figure 4) and CEA while the sarcomatous component was positive for SMA (Figure 5), desmin (Figure 6), and vimentin (Figure 7).


Carcinosarcoma of the Rectum: Report of a Rare Colorectal Malignancy and Review of the Literature.

Sudlow A, Liu MH, Waters G, Velchuru VR - Case Rep Surg (2015)

Positive staining for desmin in the sarcomatous component.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4664799&req=5

fig6: Positive staining for desmin in the sarcomatous component.
Mentions: Given the heterogeneous nature of the tumour, the two components showed distinct immunohistochemistry. The epithelial component stained positively for CK20 (Figure 4) and CEA while the sarcomatous component was positive for SMA (Figure 5), desmin (Figure 6), and vimentin (Figure 7).

Bottom Line: Histologically, it is composed of two distinct elements of epithelial and mesenchymal origin.Prognosis is poor despite intervention with the majority of patients dying within six months.Due to the rarity of this condition, there are no specific treatment guidelines presently available.

View Article: PubMed Central - PubMed

Affiliation: Department of Colorectal Surgery, James Paget University Hospital, Gorleston NR31 6LA, UK.

ABSTRACT
Carcinosarcoma (CS) is a rare mixed mesodermal malignancy most commonly affecting the female reproductive organs, respiratory tract, head, and neck. Though infrequent, it may affect the gastrointestinal tract, most often the oesophagus and only very rarely the rectum. Histologically, it is composed of two distinct elements of epithelial and mesenchymal origin. Clinically, it is a very aggressive tumour with many patients presenting with metastatic lymph nodes or distant metastases at the time of diagnosis. Prognosis is poor despite intervention with the majority of patients dying within six months. Due to the rarity of this condition, there are no specific treatment guidelines presently available. We describe the case of an 80-year-old patient with carcinosarcoma of the rectum with discussion of the immunohistochemistry and review the available literature pertaining to this rare presentation.

No MeSH data available.


Related in: MedlinePlus