Limits...
The Chinese Herb Jianpijiedu Contributes to the Regulation of OATP1B2 and ABCC2 in a Rat Model of Orthotopic Transplantation Liver Cancer Pretreated with Food Restriction and Diarrhea.

Sun B, Chen Y, Xiang T, Zhang L, Chen Z, Zhang S, Zhou H, Chen S - Biomed Res Int (2015)

Bottom Line: Traditional Chinese Medicine Jianpijiedu decoction (JPJD) could improve the general status of liver cancer patients in clinics, especially the symptoms of decreased food intake and diarrhea.It was also shown that the high dose of JPJD significantly improved the survival rate, weight, and organ weight when compared with FRD-LC-induced rats.Moreover, JPJD administration upregulated the mRNA and protein levels of ABCC2 and downregulated the mRNA and protein levels of OATP1B2 in liver tissues.

View Article: PubMed Central - PubMed

Affiliation: Department of Traditional Chinese Medicine, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou 510080, China.

ABSTRACT
Traditional Chinese Medicine Jianpijiedu decoction (JPJD) could improve the general status of liver cancer patients in clinics, especially the symptoms of decreased food intake and diarrhea. In this study, our results showed that the survival rate of the liver cancer with food restriction and diarrhea (FRD-LC) rats was lower than the liver cancer (LC) rats, and the tumor volume of the FRD-LC rats was higher than the LC rats. It was also shown that the high dose of JPJD significantly improved the survival rate, weight, and organ weight when compared with FRD-LC-induced rats. Moreover, JPJD administration upregulated the mRNA and protein levels of ABCC2 and downregulated the mRNA and protein levels of OATP1B2 in liver tissues. However, opposite results were observed in the cancer tissues. In conclusion, the study indicated that the Chinese Medicine JPJD could contribute to the rats with liver cancer which were pretreated with food restriction and diarrhea by regulating the expression of ABCC2 and OATP1B2 in liver tissues and cancer tissues.

No MeSH data available.


Related in: MedlinePlus

Survival analysis. Kaplan-Meier and Log-Rank (Mantel-Cox) Pairwise Comparison test of survival distributions for different levels of each group. F-censored and G-censored: when the study was completed on the 42nd day, there were alive rats in Group F (n = 3) and Group G (n = 8), but the survival time was not observed.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4664790&req=5

fig1: Survival analysis. Kaplan-Meier and Log-Rank (Mantel-Cox) Pairwise Comparison test of survival distributions for different levels of each group. F-censored and G-censored: when the study was completed on the 42nd day, there were alive rats in Group F (n = 3) and Group G (n = 8), but the survival time was not observed.

Mentions: The survival analysis illustrated in Figure 1 indicated that the FRD-LC rats (Group D) have poorer survival rate when compared with the LC rats (Group B) (P < 0.01). The rats treated with the high dose of JPJD (Group G) survived longer compared with the other rats (P < 0.05). The FRD-LC rats (Group D) and the FRD-LC rats treated with the low dose of JPJD (Group E) survived for a shorter time compared with the other rats (P < 0.05). The LC rats (Group B) and the FRD-LC rats treated with the medium dose of JPJD (Group F) had an intermediate survival time. These results indicated that the FRD model was a promoting factor in the fatality rate of the FRD-LC model even when the FRD model was terminated, and the administration of 37.5 g·kg−1 JPJD could improve the survival rate of liver cancer (Figure 1).


The Chinese Herb Jianpijiedu Contributes to the Regulation of OATP1B2 and ABCC2 in a Rat Model of Orthotopic Transplantation Liver Cancer Pretreated with Food Restriction and Diarrhea.

Sun B, Chen Y, Xiang T, Zhang L, Chen Z, Zhang S, Zhou H, Chen S - Biomed Res Int (2015)

Survival analysis. Kaplan-Meier and Log-Rank (Mantel-Cox) Pairwise Comparison test of survival distributions for different levels of each group. F-censored and G-censored: when the study was completed on the 42nd day, there were alive rats in Group F (n = 3) and Group G (n = 8), but the survival time was not observed.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664790&req=5

fig1: Survival analysis. Kaplan-Meier and Log-Rank (Mantel-Cox) Pairwise Comparison test of survival distributions for different levels of each group. F-censored and G-censored: when the study was completed on the 42nd day, there were alive rats in Group F (n = 3) and Group G (n = 8), but the survival time was not observed.
Mentions: The survival analysis illustrated in Figure 1 indicated that the FRD-LC rats (Group D) have poorer survival rate when compared with the LC rats (Group B) (P < 0.01). The rats treated with the high dose of JPJD (Group G) survived longer compared with the other rats (P < 0.05). The FRD-LC rats (Group D) and the FRD-LC rats treated with the low dose of JPJD (Group E) survived for a shorter time compared with the other rats (P < 0.05). The LC rats (Group B) and the FRD-LC rats treated with the medium dose of JPJD (Group F) had an intermediate survival time. These results indicated that the FRD model was a promoting factor in the fatality rate of the FRD-LC model even when the FRD model was terminated, and the administration of 37.5 g·kg−1 JPJD could improve the survival rate of liver cancer (Figure 1).

Bottom Line: Traditional Chinese Medicine Jianpijiedu decoction (JPJD) could improve the general status of liver cancer patients in clinics, especially the symptoms of decreased food intake and diarrhea.It was also shown that the high dose of JPJD significantly improved the survival rate, weight, and organ weight when compared with FRD-LC-induced rats.Moreover, JPJD administration upregulated the mRNA and protein levels of ABCC2 and downregulated the mRNA and protein levels of OATP1B2 in liver tissues.

View Article: PubMed Central - PubMed

Affiliation: Department of Traditional Chinese Medicine, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou 510080, China.

ABSTRACT
Traditional Chinese Medicine Jianpijiedu decoction (JPJD) could improve the general status of liver cancer patients in clinics, especially the symptoms of decreased food intake and diarrhea. In this study, our results showed that the survival rate of the liver cancer with food restriction and diarrhea (FRD-LC) rats was lower than the liver cancer (LC) rats, and the tumor volume of the FRD-LC rats was higher than the LC rats. It was also shown that the high dose of JPJD significantly improved the survival rate, weight, and organ weight when compared with FRD-LC-induced rats. Moreover, JPJD administration upregulated the mRNA and protein levels of ABCC2 and downregulated the mRNA and protein levels of OATP1B2 in liver tissues. However, opposite results were observed in the cancer tissues. In conclusion, the study indicated that the Chinese Medicine JPJD could contribute to the rats with liver cancer which were pretreated with food restriction and diarrhea by regulating the expression of ABCC2 and OATP1B2 in liver tissues and cancer tissues.

No MeSH data available.


Related in: MedlinePlus