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Age-Related Inter-Region EEG Coupling Changes During the Control of Bottom-Up and Top-Down Attention.

Li L, Zhao D - Front Aging Neurosci (2015)

Bottom Line: Specifically, prefronto-frontal coupling in theta- and alpha-bands, fronto-parietal and parieto-occipital couplings in beta-band for younger group showed a right hemispheric dominance, which was reduced with aging to compensate for the inhibitory dysfunction.While pop-out target detection was mainly associated with greater parieto-occipital beta-coupling strength compared to search condition regardless of aging.Taken together these findings provide evidence that prefronto-frontal coupling of theta-, alpha-, and beta-bands may serve as a possible basis of aging during visual attention, while parieto-occipital coupling in beta-band could serve for a bottom-up function and be vulnerable to top-down attention control for younger and older groups.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China Chengdu, China.

ABSTRACT
We investigated age-related changes in electroencephalographic (EEG) coupling of theta-, alpha-, and beta-frequency bands during bottom-up and top-down attention. Arrays were presented with either automatic "pop-out" (bottom-up) or effortful "search" (top-down) behavior to younger and older participants. The phase-locking value was used to estimate coupling strength between scalp recordings. Behavioral performance decreased with age, with a greater age-related decline in accuracy for the search than for the pop-out condition. Aging was associated with a declined coupling strength of theta and alpha frequency bands, with a greater age-related decline in whole-brain coupling values for the search than for the pop-out condition. Specifically, prefronto-frontal coupling in theta- and alpha-bands, fronto-parietal and parieto-occipital couplings in beta-band for younger group showed a right hemispheric dominance, which was reduced with aging to compensate for the inhibitory dysfunction. While pop-out target detection was mainly associated with greater parieto-occipital beta-coupling strength compared to search condition regardless of aging. Furthermore, prefronto-frontal coupling in theta-, alpha-, and beta-bands, and parieto-occipital coupling in beta-band functioned as predictors of behavior for both groups. Taken together these findings provide evidence that prefronto-frontal coupling of theta-, alpha-, and beta-bands may serve as a possible basis of aging during visual attention, while parieto-occipital coupling in beta-band could serve for a bottom-up function and be vulnerable to top-down attention control for younger and older groups.

No MeSH data available.


Related in: MedlinePlus

(A) Inter-regions coupling in alpha frequency band. Blue lines indicate main effect of age (younger > older) and red line indicates main effect of condition (pop-out > search). (B) Coupling values between left prefrontal and central-frontal regions as a function of target field and condition in younger subjects, with greater coupling values in the left field target and in the pop-out condition. There was only a main effect of condition for the older group, with greater coupling values in the pop-out condition. (C) Coupling values between right prefrontal and central-frontal regions as a function of target field in younger and older subjects, with greater coupling values in left target than in right target for younger subjects and no difference between right and left targets for old subjects. (D) Linear negative regression between mean RT and coupling value between left prefrontal and central-frontal regions for the pop-out condition with the left field target in the younger group. Linear positive regression between mean RT and coupling value between left prefrontal and central-frontal regions for the pop-out condition with the left field target (E) and for the search condition with the right target (F) in the older group. (G) Linear negative regression between mean accuracy and coupling value between right prefrontal and central-frontal regions for the search condition with the right target in the older group.
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Figure 4: (A) Inter-regions coupling in alpha frequency band. Blue lines indicate main effect of age (younger > older) and red line indicates main effect of condition (pop-out > search). (B) Coupling values between left prefrontal and central-frontal regions as a function of target field and condition in younger subjects, with greater coupling values in the left field target and in the pop-out condition. There was only a main effect of condition for the older group, with greater coupling values in the pop-out condition. (C) Coupling values between right prefrontal and central-frontal regions as a function of target field in younger and older subjects, with greater coupling values in left target than in right target for younger subjects and no difference between right and left targets for old subjects. (D) Linear negative regression between mean RT and coupling value between left prefrontal and central-frontal regions for the pop-out condition with the left field target in the younger group. Linear positive regression between mean RT and coupling value between left prefrontal and central-frontal regions for the pop-out condition with the left field target (E) and for the search condition with the right target (F) in the older group. (G) Linear negative regression between mean accuracy and coupling value between right prefrontal and central-frontal regions for the search condition with the right target in the older group.

Mentions: Figure 4A summarizes the main effect of age (blue) and condition (red) among eight regions of interest. As can be seen in Figure 4A, there was a main effect of age for coupling values on two long range connections, including the connections between left prefrontal and left central-frontal regions [1 and 3, F(1,24) = 5.174, p = 0.03], between right prefrontal and right central-frontal regions [2 and 4, F(1,24) = 5.87, p = 0.02], with smaller coupling values for older subjects. There was a main effect of condition for coupling values on connections between left prefrontal and left central-frontal regions [1 and 3, F(1,24) = 14.03, p = 0.001], between left central-frontal and left central-parietal regions [3 and 5, F(1,24) = 5.87, p = 0.02], with smaller coupling values in search condition.


Age-Related Inter-Region EEG Coupling Changes During the Control of Bottom-Up and Top-Down Attention.

Li L, Zhao D - Front Aging Neurosci (2015)

(A) Inter-regions coupling in alpha frequency band. Blue lines indicate main effect of age (younger > older) and red line indicates main effect of condition (pop-out > search). (B) Coupling values between left prefrontal and central-frontal regions as a function of target field and condition in younger subjects, with greater coupling values in the left field target and in the pop-out condition. There was only a main effect of condition for the older group, with greater coupling values in the pop-out condition. (C) Coupling values between right prefrontal and central-frontal regions as a function of target field in younger and older subjects, with greater coupling values in left target than in right target for younger subjects and no difference between right and left targets for old subjects. (D) Linear negative regression between mean RT and coupling value between left prefrontal and central-frontal regions for the pop-out condition with the left field target in the younger group. Linear positive regression between mean RT and coupling value between left prefrontal and central-frontal regions for the pop-out condition with the left field target (E) and for the search condition with the right target (F) in the older group. (G) Linear negative regression between mean accuracy and coupling value between right prefrontal and central-frontal regions for the search condition with the right target in the older group.
© Copyright Policy
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4664751&req=5

Figure 4: (A) Inter-regions coupling in alpha frequency band. Blue lines indicate main effect of age (younger > older) and red line indicates main effect of condition (pop-out > search). (B) Coupling values between left prefrontal and central-frontal regions as a function of target field and condition in younger subjects, with greater coupling values in the left field target and in the pop-out condition. There was only a main effect of condition for the older group, with greater coupling values in the pop-out condition. (C) Coupling values between right prefrontal and central-frontal regions as a function of target field in younger and older subjects, with greater coupling values in left target than in right target for younger subjects and no difference between right and left targets for old subjects. (D) Linear negative regression between mean RT and coupling value between left prefrontal and central-frontal regions for the pop-out condition with the left field target in the younger group. Linear positive regression between mean RT and coupling value between left prefrontal and central-frontal regions for the pop-out condition with the left field target (E) and for the search condition with the right target (F) in the older group. (G) Linear negative regression between mean accuracy and coupling value between right prefrontal and central-frontal regions for the search condition with the right target in the older group.
Mentions: Figure 4A summarizes the main effect of age (blue) and condition (red) among eight regions of interest. As can be seen in Figure 4A, there was a main effect of age for coupling values on two long range connections, including the connections between left prefrontal and left central-frontal regions [1 and 3, F(1,24) = 5.174, p = 0.03], between right prefrontal and right central-frontal regions [2 and 4, F(1,24) = 5.87, p = 0.02], with smaller coupling values for older subjects. There was a main effect of condition for coupling values on connections between left prefrontal and left central-frontal regions [1 and 3, F(1,24) = 14.03, p = 0.001], between left central-frontal and left central-parietal regions [3 and 5, F(1,24) = 5.87, p = 0.02], with smaller coupling values in search condition.

Bottom Line: Specifically, prefronto-frontal coupling in theta- and alpha-bands, fronto-parietal and parieto-occipital couplings in beta-band for younger group showed a right hemispheric dominance, which was reduced with aging to compensate for the inhibitory dysfunction.While pop-out target detection was mainly associated with greater parieto-occipital beta-coupling strength compared to search condition regardless of aging.Taken together these findings provide evidence that prefronto-frontal coupling of theta-, alpha-, and beta-bands may serve as a possible basis of aging during visual attention, while parieto-occipital coupling in beta-band could serve for a bottom-up function and be vulnerable to top-down attention control for younger and older groups.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China Chengdu, China.

ABSTRACT
We investigated age-related changes in electroencephalographic (EEG) coupling of theta-, alpha-, and beta-frequency bands during bottom-up and top-down attention. Arrays were presented with either automatic "pop-out" (bottom-up) or effortful "search" (top-down) behavior to younger and older participants. The phase-locking value was used to estimate coupling strength between scalp recordings. Behavioral performance decreased with age, with a greater age-related decline in accuracy for the search than for the pop-out condition. Aging was associated with a declined coupling strength of theta and alpha frequency bands, with a greater age-related decline in whole-brain coupling values for the search than for the pop-out condition. Specifically, prefronto-frontal coupling in theta- and alpha-bands, fronto-parietal and parieto-occipital couplings in beta-band for younger group showed a right hemispheric dominance, which was reduced with aging to compensate for the inhibitory dysfunction. While pop-out target detection was mainly associated with greater parieto-occipital beta-coupling strength compared to search condition regardless of aging. Furthermore, prefronto-frontal coupling in theta-, alpha-, and beta-bands, and parieto-occipital coupling in beta-band functioned as predictors of behavior for both groups. Taken together these findings provide evidence that prefronto-frontal coupling of theta-, alpha-, and beta-bands may serve as a possible basis of aging during visual attention, while parieto-occipital coupling in beta-band could serve for a bottom-up function and be vulnerable to top-down attention control for younger and older groups.

No MeSH data available.


Related in: MedlinePlus