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Genome wide transcription profiling reveals a major role for the transcription factor Atf1 in regulation of cell division in Schizosaccharomyces pombe.

Bandyopadhyay S, Sundaram G - Genom Data (2015)

Bottom Line: Deregulated activities of transcription factors that contribute to this programmed gene expression, are associated with many diseases including cancer.The microarray data are available at NCBI's Gene Expression Omnibus (GEO) Series (accession number GSE71820).Here we report the annotation of the genes whose expression get altered by Atf1 overexpression and also provide details related to sample processing and statistical analysis of our microarray data.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry and Centre for Research in Nanoscience and Nanotechnology, University of Calcutta, 35, Ballygunje Circular Road, Kolkata 700019, WB, India.

ABSTRACT
The mechanism underlying stringently controlled sequence of events in the eukaryotic cell cycle involves periodic transcription of a number of genes encoding important regulators of cell cycle, growth, proliferation and apoptosis. Deregulated activities of transcription factors that contribute to this programmed gene expression, are associated with many diseases including cancer. A detailed mechanistic understanding of the transcriptional control associated with cell division is, therefore, important. We have reported earlier that the transcription factor Atf1 in Schizosaccharomyces pombe can regulate G2-M transition by directly controlling the expression of the mitotic cyclin Cdc13 (1).To gain a better understanding of the role of Atf1 in cell cycle, we performed a microarray based identification of cell cycle related targets of Atf1. The microarray data are available at NCBI's Gene Expression Omnibus (GEO) Series (accession number GSE71820). Here we report the annotation of the genes whose expression get altered by Atf1 overexpression and also provide details related to sample processing and statistical analysis of our microarray data.

No MeSH data available.


Related in: MedlinePlus

Transcriptional program of S. pombe cell cycle: Important genes related to a particular cell cycle transition event are shown. The transcription factors regulating their expression are shown in ‘blue’ boxes. Subunit composition of both MBF and PBF transcription factors are shown. Genes whose expression can be additionally regulated by Atf1 are indicated in ‘red’ font.
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f0010: Transcriptional program of S. pombe cell cycle: Important genes related to a particular cell cycle transition event are shown. The transcription factors regulating their expression are shown in ‘blue’ boxes. Subunit composition of both MBF and PBF transcription factors are shown. Genes whose expression can be additionally regulated by Atf1 are indicated in ‘red’ font.

Mentions: In S. pombe about 747 genes with cell cycle dependent expression patterns have been identified [10], [11], [12]. The transcription program during S phase entry and progression is regulated by the MBF/DSC1 transcription factor complex (similar to the mammalian E2F/DP) composed of Cdc10, Res1 and Res2 (13). Expression of genes that regulate the transition from M–G1 is controlled by the PBF transcription factor (14). Very little is known about the transcription factors that drive G2/M progression. Our lab was the first to identify that the transcription factor Atf1 controls the expression of the mitotic cyclin cdc13+, related to G2/M transition in S. pombe(1). Fig. 2 provides a schematic illustration of genes that are known to be important for G2–M; M–G1 and G1–S transitions in the S. pombe cell cycle [12], [13], [14]. Red font has been used to highlight the genes that were identified in our screen.


Genome wide transcription profiling reveals a major role for the transcription factor Atf1 in regulation of cell division in Schizosaccharomyces pombe.

Bandyopadhyay S, Sundaram G - Genom Data (2015)

Transcriptional program of S. pombe cell cycle: Important genes related to a particular cell cycle transition event are shown. The transcription factors regulating their expression are shown in ‘blue’ boxes. Subunit composition of both MBF and PBF transcription factors are shown. Genes whose expression can be additionally regulated by Atf1 are indicated in ‘red’ font.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664745&req=5

f0010: Transcriptional program of S. pombe cell cycle: Important genes related to a particular cell cycle transition event are shown. The transcription factors regulating their expression are shown in ‘blue’ boxes. Subunit composition of both MBF and PBF transcription factors are shown. Genes whose expression can be additionally regulated by Atf1 are indicated in ‘red’ font.
Mentions: In S. pombe about 747 genes with cell cycle dependent expression patterns have been identified [10], [11], [12]. The transcription program during S phase entry and progression is regulated by the MBF/DSC1 transcription factor complex (similar to the mammalian E2F/DP) composed of Cdc10, Res1 and Res2 (13). Expression of genes that regulate the transition from M–G1 is controlled by the PBF transcription factor (14). Very little is known about the transcription factors that drive G2/M progression. Our lab was the first to identify that the transcription factor Atf1 controls the expression of the mitotic cyclin cdc13+, related to G2/M transition in S. pombe(1). Fig. 2 provides a schematic illustration of genes that are known to be important for G2–M; M–G1 and G1–S transitions in the S. pombe cell cycle [12], [13], [14]. Red font has been used to highlight the genes that were identified in our screen.

Bottom Line: Deregulated activities of transcription factors that contribute to this programmed gene expression, are associated with many diseases including cancer.The microarray data are available at NCBI's Gene Expression Omnibus (GEO) Series (accession number GSE71820).Here we report the annotation of the genes whose expression get altered by Atf1 overexpression and also provide details related to sample processing and statistical analysis of our microarray data.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry and Centre for Research in Nanoscience and Nanotechnology, University of Calcutta, 35, Ballygunje Circular Road, Kolkata 700019, WB, India.

ABSTRACT
The mechanism underlying stringently controlled sequence of events in the eukaryotic cell cycle involves periodic transcription of a number of genes encoding important regulators of cell cycle, growth, proliferation and apoptosis. Deregulated activities of transcription factors that contribute to this programmed gene expression, are associated with many diseases including cancer. A detailed mechanistic understanding of the transcriptional control associated with cell division is, therefore, important. We have reported earlier that the transcription factor Atf1 in Schizosaccharomyces pombe can regulate G2-M transition by directly controlling the expression of the mitotic cyclin Cdc13 (1).To gain a better understanding of the role of Atf1 in cell cycle, we performed a microarray based identification of cell cycle related targets of Atf1. The microarray data are available at NCBI's Gene Expression Omnibus (GEO) Series (accession number GSE71820). Here we report the annotation of the genes whose expression get altered by Atf1 overexpression and also provide details related to sample processing and statistical analysis of our microarray data.

No MeSH data available.


Related in: MedlinePlus