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Genome wide transcription profiling reveals a major role for the transcription factor Atf1 in regulation of cell division in Schizosaccharomyces pombe.

Bandyopadhyay S, Sundaram G - Genom Data (2015)

Bottom Line: Deregulated activities of transcription factors that contribute to this programmed gene expression, are associated with many diseases including cancer.The microarray data are available at NCBI's Gene Expression Omnibus (GEO) Series (accession number GSE71820).Here we report the annotation of the genes whose expression get altered by Atf1 overexpression and also provide details related to sample processing and statistical analysis of our microarray data.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry and Centre for Research in Nanoscience and Nanotechnology, University of Calcutta, 35, Ballygunje Circular Road, Kolkata 700019, WB, India.

ABSTRACT
The mechanism underlying stringently controlled sequence of events in the eukaryotic cell cycle involves periodic transcription of a number of genes encoding important regulators of cell cycle, growth, proliferation and apoptosis. Deregulated activities of transcription factors that contribute to this programmed gene expression, are associated with many diseases including cancer. A detailed mechanistic understanding of the transcriptional control associated with cell division is, therefore, important. We have reported earlier that the transcription factor Atf1 in Schizosaccharomyces pombe can regulate G2-M transition by directly controlling the expression of the mitotic cyclin Cdc13 (1).To gain a better understanding of the role of Atf1 in cell cycle, we performed a microarray based identification of cell cycle related targets of Atf1. The microarray data are available at NCBI's Gene Expression Omnibus (GEO) Series (accession number GSE71820). Here we report the annotation of the genes whose expression get altered by Atf1 overexpression and also provide details related to sample processing and statistical analysis of our microarray data.

No MeSH data available.


Related in: MedlinePlus

Distribution of the genes induced during Atf1 overexpression in S. pombe cells. The number of genes corresponding to the top 10 categories of upregulated genes is shown.
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f0005: Distribution of the genes induced during Atf1 overexpression in S. pombe cells. The number of genes corresponding to the top 10 categories of upregulated genes is shown.

Mentions: Fig. 1 shows the distribution of the number of genes classified under each of these 10 categories. Here again it can be clearly seen that the highest number of genes were identified in the “GO: 0022402–cell cycle process” category. Thus our analysis clearly shows that Atf1 overexpression significantly alters the pattern of cell cycle related transcription in S. pombe cells.


Genome wide transcription profiling reveals a major role for the transcription factor Atf1 in regulation of cell division in Schizosaccharomyces pombe.

Bandyopadhyay S, Sundaram G - Genom Data (2015)

Distribution of the genes induced during Atf1 overexpression in S. pombe cells. The number of genes corresponding to the top 10 categories of upregulated genes is shown.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664745&req=5

f0005: Distribution of the genes induced during Atf1 overexpression in S. pombe cells. The number of genes corresponding to the top 10 categories of upregulated genes is shown.
Mentions: Fig. 1 shows the distribution of the number of genes classified under each of these 10 categories. Here again it can be clearly seen that the highest number of genes were identified in the “GO: 0022402–cell cycle process” category. Thus our analysis clearly shows that Atf1 overexpression significantly alters the pattern of cell cycle related transcription in S. pombe cells.

Bottom Line: Deregulated activities of transcription factors that contribute to this programmed gene expression, are associated with many diseases including cancer.The microarray data are available at NCBI's Gene Expression Omnibus (GEO) Series (accession number GSE71820).Here we report the annotation of the genes whose expression get altered by Atf1 overexpression and also provide details related to sample processing and statistical analysis of our microarray data.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry and Centre for Research in Nanoscience and Nanotechnology, University of Calcutta, 35, Ballygunje Circular Road, Kolkata 700019, WB, India.

ABSTRACT
The mechanism underlying stringently controlled sequence of events in the eukaryotic cell cycle involves periodic transcription of a number of genes encoding important regulators of cell cycle, growth, proliferation and apoptosis. Deregulated activities of transcription factors that contribute to this programmed gene expression, are associated with many diseases including cancer. A detailed mechanistic understanding of the transcriptional control associated with cell division is, therefore, important. We have reported earlier that the transcription factor Atf1 in Schizosaccharomyces pombe can regulate G2-M transition by directly controlling the expression of the mitotic cyclin Cdc13 (1).To gain a better understanding of the role of Atf1 in cell cycle, we performed a microarray based identification of cell cycle related targets of Atf1. The microarray data are available at NCBI's Gene Expression Omnibus (GEO) Series (accession number GSE71820). Here we report the annotation of the genes whose expression get altered by Atf1 overexpression and also provide details related to sample processing and statistical analysis of our microarray data.

No MeSH data available.


Related in: MedlinePlus