Limits...
Impulsivity is Associated with Increased Metabolism in the Fronto-Insular Network in Parkinson's Disease.

Tahmasian M, Rochhausen L, Maier F, Williamson KL, Drzezga A, Timmermann L, Van Eimeren T, Eggers C - Front Behav Neurosci (2015)

Bottom Line: Voxel-wise group comparison revealed higher FDG-metabolism in the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), and right insula in patients with higher impulsivity scores.Moreover, there was a positive correlation between the FDG-metabolism and BIS scores.Our findings provide evidence that high impulsivity is associated with increased FDG-metabolism within the fronto-insular network in PD.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, University Hospital of Cologne Cologne, Germany ; Department of Nuclear Medicine, University Hospital of Cologne Cologne, Germany ; Sleep Disorders Research Center, Kermanshah University of Medical Sciences (KUMS) Kermanshah, Iran.

ABSTRACT
Various neuroimaging studies demonstrated that the fronto-insular network is implicated in impulsive behavior. We compared glucose metabolism (as a proxy measure of neural activity) among 24 patients with Parkinson's disease (PD) who presented with low or high levels of impulsivity based on the Barratt Impulsiveness Scale 11 (BIS) scores. Subjects underwent 18-fluorodeoxyglucose positron emission tomography (FDG-PET) and the voxel-wise group difference of FDG-metabolism was analyzed in Statistical Parametric Mapping (SPM8). Subsequently, we performed a partial correlation analysis between the FDG-metabolism and BIS scores, controlling for covariates (i.e., age, sex, severity of disease and levodopa equivalent daily doses). Voxel-wise group comparison revealed higher FDG-metabolism in the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), and right insula in patients with higher impulsivity scores. Moreover, there was a positive correlation between the FDG-metabolism and BIS scores. Our findings provide evidence that high impulsivity is associated with increased FDG-metabolism within the fronto-insular network in PD.

No MeSH data available.


Related in: MedlinePlus

Positive correlation between the averaged FDG-metabolism within the group comparison volume-of-interest (i.e., the fronto-insular network) extracted for each subject and the total BIS scores (A), attention BIS score (B), motor BIS score (C), non-planning BIS score (D). Partial correlations were performed across all 24 PD patients with additional covariates such as age, sex, severity of disease and LEDD for dopamine agonists; *p < 0.05). BIS, Barratt Impulsiveness Scale; LEDD, levodopa equivalent daily dose.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4664667&req=5

Figure 2: Positive correlation between the averaged FDG-metabolism within the group comparison volume-of-interest (i.e., the fronto-insular network) extracted for each subject and the total BIS scores (A), attention BIS score (B), motor BIS score (C), non-planning BIS score (D). Partial correlations were performed across all 24 PD patients with additional covariates such as age, sex, severity of disease and LEDD for dopamine agonists; *p < 0.05). BIS, Barratt Impulsiveness Scale; LEDD, levodopa equivalent daily dose.

Mentions: We assessed the link between FDG-metabolism of the fronto-insular network and BIS scores. Results showed a positive correlation between the averaged FDG-metabolism and total BIS scores (r = 0.761, p < 0.001) across all patients (Figure 2A). Furthermore, significant positive correlations were found between the FDG-metabolism and BIS sub-score for attention (r = 0.646, p < 0.05), motor (r = 0.506, p < 0.05), and non-planning impulsivity (r = 0.670, p < 0.001; Figures 2B–D).


Impulsivity is Associated with Increased Metabolism in the Fronto-Insular Network in Parkinson's Disease.

Tahmasian M, Rochhausen L, Maier F, Williamson KL, Drzezga A, Timmermann L, Van Eimeren T, Eggers C - Front Behav Neurosci (2015)

Positive correlation between the averaged FDG-metabolism within the group comparison volume-of-interest (i.e., the fronto-insular network) extracted for each subject and the total BIS scores (A), attention BIS score (B), motor BIS score (C), non-planning BIS score (D). Partial correlations were performed across all 24 PD patients with additional covariates such as age, sex, severity of disease and LEDD for dopamine agonists; *p < 0.05). BIS, Barratt Impulsiveness Scale; LEDD, levodopa equivalent daily dose.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664667&req=5

Figure 2: Positive correlation between the averaged FDG-metabolism within the group comparison volume-of-interest (i.e., the fronto-insular network) extracted for each subject and the total BIS scores (A), attention BIS score (B), motor BIS score (C), non-planning BIS score (D). Partial correlations were performed across all 24 PD patients with additional covariates such as age, sex, severity of disease and LEDD for dopamine agonists; *p < 0.05). BIS, Barratt Impulsiveness Scale; LEDD, levodopa equivalent daily dose.
Mentions: We assessed the link between FDG-metabolism of the fronto-insular network and BIS scores. Results showed a positive correlation between the averaged FDG-metabolism and total BIS scores (r = 0.761, p < 0.001) across all patients (Figure 2A). Furthermore, significant positive correlations were found between the FDG-metabolism and BIS sub-score for attention (r = 0.646, p < 0.05), motor (r = 0.506, p < 0.05), and non-planning impulsivity (r = 0.670, p < 0.001; Figures 2B–D).

Bottom Line: Voxel-wise group comparison revealed higher FDG-metabolism in the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), and right insula in patients with higher impulsivity scores.Moreover, there was a positive correlation between the FDG-metabolism and BIS scores.Our findings provide evidence that high impulsivity is associated with increased FDG-metabolism within the fronto-insular network in PD.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, University Hospital of Cologne Cologne, Germany ; Department of Nuclear Medicine, University Hospital of Cologne Cologne, Germany ; Sleep Disorders Research Center, Kermanshah University of Medical Sciences (KUMS) Kermanshah, Iran.

ABSTRACT
Various neuroimaging studies demonstrated that the fronto-insular network is implicated in impulsive behavior. We compared glucose metabolism (as a proxy measure of neural activity) among 24 patients with Parkinson's disease (PD) who presented with low or high levels of impulsivity based on the Barratt Impulsiveness Scale 11 (BIS) scores. Subjects underwent 18-fluorodeoxyglucose positron emission tomography (FDG-PET) and the voxel-wise group difference of FDG-metabolism was analyzed in Statistical Parametric Mapping (SPM8). Subsequently, we performed a partial correlation analysis between the FDG-metabolism and BIS scores, controlling for covariates (i.e., age, sex, severity of disease and levodopa equivalent daily doses). Voxel-wise group comparison revealed higher FDG-metabolism in the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), and right insula in patients with higher impulsivity scores. Moreover, there was a positive correlation between the FDG-metabolism and BIS scores. Our findings provide evidence that high impulsivity is associated with increased FDG-metabolism within the fronto-insular network in PD.

No MeSH data available.


Related in: MedlinePlus