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Impulsivity is Associated with Increased Metabolism in the Fronto-Insular Network in Parkinson's Disease.

Tahmasian M, Rochhausen L, Maier F, Williamson KL, Drzezga A, Timmermann L, Van Eimeren T, Eggers C - Front Behav Neurosci (2015)

Bottom Line: Voxel-wise group comparison revealed higher FDG-metabolism in the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), and right insula in patients with higher impulsivity scores.Moreover, there was a positive correlation between the FDG-metabolism and BIS scores.Our findings provide evidence that high impulsivity is associated with increased FDG-metabolism within the fronto-insular network in PD.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, University Hospital of Cologne Cologne, Germany ; Department of Nuclear Medicine, University Hospital of Cologne Cologne, Germany ; Sleep Disorders Research Center, Kermanshah University of Medical Sciences (KUMS) Kermanshah, Iran.

ABSTRACT
Various neuroimaging studies demonstrated that the fronto-insular network is implicated in impulsive behavior. We compared glucose metabolism (as a proxy measure of neural activity) among 24 patients with Parkinson's disease (PD) who presented with low or high levels of impulsivity based on the Barratt Impulsiveness Scale 11 (BIS) scores. Subjects underwent 18-fluorodeoxyglucose positron emission tomography (FDG-PET) and the voxel-wise group difference of FDG-metabolism was analyzed in Statistical Parametric Mapping (SPM8). Subsequently, we performed a partial correlation analysis between the FDG-metabolism and BIS scores, controlling for covariates (i.e., age, sex, severity of disease and levodopa equivalent daily doses). Voxel-wise group comparison revealed higher FDG-metabolism in the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), and right insula in patients with higher impulsivity scores. Moreover, there was a positive correlation between the FDG-metabolism and BIS scores. Our findings provide evidence that high impulsivity is associated with increased FDG-metabolism within the fronto-insular network in PD.

No MeSH data available.


Related in: MedlinePlus

(A) Voxel-wise group comparison of FDG-metabolism generated by independent t-test in SPM8. Red maps illustrate increased metabolism in PD patients with higher impulsivity compared to PD patients with lower impulsivity in the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), and right insula (p < 0.05, FWE corrected in cluster level, bars represent range of t-values). (B) Group difference based on the averaged FDG-metabolism of the fronto-insular network including the OFC, ACC, and insula within (*p < 0.001).
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Figure 1: (A) Voxel-wise group comparison of FDG-metabolism generated by independent t-test in SPM8. Red maps illustrate increased metabolism in PD patients with higher impulsivity compared to PD patients with lower impulsivity in the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), and right insula (p < 0.05, FWE corrected in cluster level, bars represent range of t-values). (B) Group difference based on the averaged FDG-metabolism of the fronto-insular network including the OFC, ACC, and insula within (*p < 0.001).

Mentions: Voxel-wise two-sample t-test between groups demonstrated higher metabolism within the fronto-insular network including the OFC, medial-frontal gyrus, ACC and insula, mainly on the right hemisphere (based on Automated Anatomical Labeling atlas; Tzourio-Mazoyer et al., 2002) in subjects with higher impulsivity level compared to individuals with lower level of impulsivity (p < 0.05, FWE corrected; Figure 1A, Table 2). Moreover, patients with higher impulsivity revealed higher averaged FDG-metabolism using the group difference VOIs determined by SPM8 (mean ± SD = 2.28 ± 0.14 vs. 1.97 ± 0.10; Figure 1B). On the other hand, PD patients with higher level of impulsivity had significant decreased FDG-metabolism in the superior parietal gyrus and occipital cortex compared to PD patients with lower level of impulsivity (p < 0.05, FWE corrected, not shown).


Impulsivity is Associated with Increased Metabolism in the Fronto-Insular Network in Parkinson's Disease.

Tahmasian M, Rochhausen L, Maier F, Williamson KL, Drzezga A, Timmermann L, Van Eimeren T, Eggers C - Front Behav Neurosci (2015)

(A) Voxel-wise group comparison of FDG-metabolism generated by independent t-test in SPM8. Red maps illustrate increased metabolism in PD patients with higher impulsivity compared to PD patients with lower impulsivity in the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), and right insula (p < 0.05, FWE corrected in cluster level, bars represent range of t-values). (B) Group difference based on the averaged FDG-metabolism of the fronto-insular network including the OFC, ACC, and insula within (*p < 0.001).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664667&req=5

Figure 1: (A) Voxel-wise group comparison of FDG-metabolism generated by independent t-test in SPM8. Red maps illustrate increased metabolism in PD patients with higher impulsivity compared to PD patients with lower impulsivity in the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), and right insula (p < 0.05, FWE corrected in cluster level, bars represent range of t-values). (B) Group difference based on the averaged FDG-metabolism of the fronto-insular network including the OFC, ACC, and insula within (*p < 0.001).
Mentions: Voxel-wise two-sample t-test between groups demonstrated higher metabolism within the fronto-insular network including the OFC, medial-frontal gyrus, ACC and insula, mainly on the right hemisphere (based on Automated Anatomical Labeling atlas; Tzourio-Mazoyer et al., 2002) in subjects with higher impulsivity level compared to individuals with lower level of impulsivity (p < 0.05, FWE corrected; Figure 1A, Table 2). Moreover, patients with higher impulsivity revealed higher averaged FDG-metabolism using the group difference VOIs determined by SPM8 (mean ± SD = 2.28 ± 0.14 vs. 1.97 ± 0.10; Figure 1B). On the other hand, PD patients with higher level of impulsivity had significant decreased FDG-metabolism in the superior parietal gyrus and occipital cortex compared to PD patients with lower level of impulsivity (p < 0.05, FWE corrected, not shown).

Bottom Line: Voxel-wise group comparison revealed higher FDG-metabolism in the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), and right insula in patients with higher impulsivity scores.Moreover, there was a positive correlation between the FDG-metabolism and BIS scores.Our findings provide evidence that high impulsivity is associated with increased FDG-metabolism within the fronto-insular network in PD.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, University Hospital of Cologne Cologne, Germany ; Department of Nuclear Medicine, University Hospital of Cologne Cologne, Germany ; Sleep Disorders Research Center, Kermanshah University of Medical Sciences (KUMS) Kermanshah, Iran.

ABSTRACT
Various neuroimaging studies demonstrated that the fronto-insular network is implicated in impulsive behavior. We compared glucose metabolism (as a proxy measure of neural activity) among 24 patients with Parkinson's disease (PD) who presented with low or high levels of impulsivity based on the Barratt Impulsiveness Scale 11 (BIS) scores. Subjects underwent 18-fluorodeoxyglucose positron emission tomography (FDG-PET) and the voxel-wise group difference of FDG-metabolism was analyzed in Statistical Parametric Mapping (SPM8). Subsequently, we performed a partial correlation analysis between the FDG-metabolism and BIS scores, controlling for covariates (i.e., age, sex, severity of disease and levodopa equivalent daily doses). Voxel-wise group comparison revealed higher FDG-metabolism in the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), and right insula in patients with higher impulsivity scores. Moreover, there was a positive correlation between the FDG-metabolism and BIS scores. Our findings provide evidence that high impulsivity is associated with increased FDG-metabolism within the fronto-insular network in PD.

No MeSH data available.


Related in: MedlinePlus