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A promising "TRAIL" of tanshinones for cancer therapy.

Ho TF, Chang CC - Biomedicine (Taipei) (2015)

Bottom Line: Combining TRAIL with agents that reverse resistance to it has proved promising in the sensitization of TRAIL-induced apoptosis.Noteworthy, natural compounds have already been validated as potential resources for TRAIL sensitizers.In this review, we focus on the recently identified TRAILsensitizing effect of tanshinones, the anticancer ingredients of the medicinal plant Salvia miltiorrhiza (Danshen in Chinese).

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, 406, Taichung, Taiwan.

ABSTRACT
An ideal cancer therapy specifically targets cancer cells while sparing normal tissues. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) elicits apoptosis by engaging its cognate death receptors (DRs-namely, DR4 and DR5. The cancer cell-selective proapoptotic action of TRAIL is highly attractive for cancer therapy, but clinical application of TRAIL is rather limited due to tumors' inherent or acquired TRAIL resistance. Combining TRAIL with agents that reverse resistance to it has proved promising in the sensitization of TRAIL-induced apoptosis. Noteworthy, natural compounds have already been validated as potential resources for TRAIL sensitizers. In this review, we focus on the recently identified TRAILsensitizing effect of tanshinones, the anticancer ingredients of the medicinal plant Salvia miltiorrhiza (Danshen in Chinese). Research from our laboratories and others have revealed the synergy of a tanshinones-TRAIL combination in diverse types of cancer cells through up-regulation of DR5 and/or down-regulation of antiapoptotic proteins such as survivin. Thus, in addition to their anticancer mechanisms, tanshinones as TRAIL sensitizers hold great potential to be translated to TRAIL-based therapeutic modalities for combatting cancer.

No MeSH data available.


Related in: MedlinePlus

The chemical structure of the main tanshinones of Danshen.Tanshinone I (left); Tanshinone IIA (center); and Crytotanshinone(right).
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Fig2: The chemical structure of the main tanshinones of Danshen.Tanshinone I (left); Tanshinone IIA (center); and Crytotanshinone(right).

Mentions: In general, the bioactive components of Danshen can be categorized into twogroups, namely, the lipophilic diterpene quinones and the water-soluble phenolicacids like salvianolic acids [6]. Thelipophilic group, composed of more than 50 diterpenoid tanshinones, showsprominent anticancer potential in addition to showing anti-inflammatory andantioxidant activities [7].Cryptotanshinone, tanshinone I, and tanshinone IIA are the three major elements ofthe lipophilic group (Figure 2), andnumerous in vitro and in vivo studies have revealed the anticancer actions as well as theunderlying mechanisms of these main tanshinones (Figure 3).


A promising "TRAIL" of tanshinones for cancer therapy.

Ho TF, Chang CC - Biomedicine (Taipei) (2015)

The chemical structure of the main tanshinones of Danshen.Tanshinone I (left); Tanshinone IIA (center); and Crytotanshinone(right).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4664605&req=5

Fig2: The chemical structure of the main tanshinones of Danshen.Tanshinone I (left); Tanshinone IIA (center); and Crytotanshinone(right).
Mentions: In general, the bioactive components of Danshen can be categorized into twogroups, namely, the lipophilic diterpene quinones and the water-soluble phenolicacids like salvianolic acids [6]. Thelipophilic group, composed of more than 50 diterpenoid tanshinones, showsprominent anticancer potential in addition to showing anti-inflammatory andantioxidant activities [7].Cryptotanshinone, tanshinone I, and tanshinone IIA are the three major elements ofthe lipophilic group (Figure 2), andnumerous in vitro and in vivo studies have revealed the anticancer actions as well as theunderlying mechanisms of these main tanshinones (Figure 3).

Bottom Line: Combining TRAIL with agents that reverse resistance to it has proved promising in the sensitization of TRAIL-induced apoptosis.Noteworthy, natural compounds have already been validated as potential resources for TRAIL sensitizers.In this review, we focus on the recently identified TRAILsensitizing effect of tanshinones, the anticancer ingredients of the medicinal plant Salvia miltiorrhiza (Danshen in Chinese).

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, 406, Taichung, Taiwan.

ABSTRACT
An ideal cancer therapy specifically targets cancer cells while sparing normal tissues. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) elicits apoptosis by engaging its cognate death receptors (DRs-namely, DR4 and DR5. The cancer cell-selective proapoptotic action of TRAIL is highly attractive for cancer therapy, but clinical application of TRAIL is rather limited due to tumors' inherent or acquired TRAIL resistance. Combining TRAIL with agents that reverse resistance to it has proved promising in the sensitization of TRAIL-induced apoptosis. Noteworthy, natural compounds have already been validated as potential resources for TRAIL sensitizers. In this review, we focus on the recently identified TRAILsensitizing effect of tanshinones, the anticancer ingredients of the medicinal plant Salvia miltiorrhiza (Danshen in Chinese). Research from our laboratories and others have revealed the synergy of a tanshinones-TRAIL combination in diverse types of cancer cells through up-regulation of DR5 and/or down-regulation of antiapoptotic proteins such as survivin. Thus, in addition to their anticancer mechanisms, tanshinones as TRAIL sensitizers hold great potential to be translated to TRAIL-based therapeutic modalities for combatting cancer.

No MeSH data available.


Related in: MedlinePlus