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A promising "TRAIL" of tanshinones for cancer therapy.

Ho TF, Chang CC - Biomedicine (Taipei) (2015)

Bottom Line: Combining TRAIL with agents that reverse resistance to it has proved promising in the sensitization of TRAIL-induced apoptosis.Noteworthy, natural compounds have already been validated as potential resources for TRAIL sensitizers.In this review, we focus on the recently identified TRAILsensitizing effect of tanshinones, the anticancer ingredients of the medicinal plant Salvia miltiorrhiza (Danshen in Chinese).

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, 406, Taichung, Taiwan.

ABSTRACT
An ideal cancer therapy specifically targets cancer cells while sparing normal tissues. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) elicits apoptosis by engaging its cognate death receptors (DRs-namely, DR4 and DR5. The cancer cell-selective proapoptotic action of TRAIL is highly attractive for cancer therapy, but clinical application of TRAIL is rather limited due to tumors' inherent or acquired TRAIL resistance. Combining TRAIL with agents that reverse resistance to it has proved promising in the sensitization of TRAIL-induced apoptosis. Noteworthy, natural compounds have already been validated as potential resources for TRAIL sensitizers. In this review, we focus on the recently identified TRAILsensitizing effect of tanshinones, the anticancer ingredients of the medicinal plant Salvia miltiorrhiza (Danshen in Chinese). Research from our laboratories and others have revealed the synergy of a tanshinones-TRAIL combination in diverse types of cancer cells through up-regulation of DR5 and/or down-regulation of antiapoptotic proteins such as survivin. Thus, in addition to their anticancer mechanisms, tanshinones as TRAIL sensitizers hold great potential to be translated to TRAIL-based therapeutic modalities for combatting cancer.

No MeSH data available.


Related in: MedlinePlus

Photographs of Salviamiltiorrhiza Bunge (Lamiaceae). (A) Propagated plants ofSalvia miltiorrhiza; (B) The aerialand root parts of harvested Salviamiltiorrhiza.
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Fig1: Photographs of Salviamiltiorrhiza Bunge (Lamiaceae). (A) Propagated plants ofSalvia miltiorrhiza; (B) The aerialand root parts of harvested Salviamiltiorrhiza.

Mentions: Cancer remains the leading cause of mortality globally. Despite advances indeveloping new therapeutic modalities for cancer, chemotherapy is still thefundamental tool for cancer treatment primarily through induction of apoptosis incancer cells. Natural compounds isolated from medicinal plants have been seen aspromising resources for novel chemotherapeutic drug discovery [1-3].In this review, we summarize the anticancer potential of tanshinones, the bioactivecomponents isolated from the dried root of the medicinal plant Salvia miltiorrhiza Bunge (Lamiaceae) (a.k.a. Danshen)(Figure 1) that has been frequently used intraditional Chinese medicine for over a thousand years to prevent or treat variousconditions including menstrual disorders, hepatitis, and cardiovascular diseases[4, 5]. In particular, we focus on the recently discovered role oftanshinones as sensitizing agents of tumor necrosis factor (TNF)-relatedapoptosis-inducing ligand (TRAIL), which has an attractive anticancer potential dueto its cancer cell-selective proapoptotic action but is often limited by thedevelopment of TRAIL-resistance in many human tumors. The mechanisms wherebytanshinones overcome TRAIL resistance and the potential translation of tanshinonesto TRAIL-based cancer remedies are also discussed herein.


A promising "TRAIL" of tanshinones for cancer therapy.

Ho TF, Chang CC - Biomedicine (Taipei) (2015)

Photographs of Salviamiltiorrhiza Bunge (Lamiaceae). (A) Propagated plants ofSalvia miltiorrhiza; (B) The aerialand root parts of harvested Salviamiltiorrhiza.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4664605&req=5

Fig1: Photographs of Salviamiltiorrhiza Bunge (Lamiaceae). (A) Propagated plants ofSalvia miltiorrhiza; (B) The aerialand root parts of harvested Salviamiltiorrhiza.
Mentions: Cancer remains the leading cause of mortality globally. Despite advances indeveloping new therapeutic modalities for cancer, chemotherapy is still thefundamental tool for cancer treatment primarily through induction of apoptosis incancer cells. Natural compounds isolated from medicinal plants have been seen aspromising resources for novel chemotherapeutic drug discovery [1-3].In this review, we summarize the anticancer potential of tanshinones, the bioactivecomponents isolated from the dried root of the medicinal plant Salvia miltiorrhiza Bunge (Lamiaceae) (a.k.a. Danshen)(Figure 1) that has been frequently used intraditional Chinese medicine for over a thousand years to prevent or treat variousconditions including menstrual disorders, hepatitis, and cardiovascular diseases[4, 5]. In particular, we focus on the recently discovered role oftanshinones as sensitizing agents of tumor necrosis factor (TNF)-relatedapoptosis-inducing ligand (TRAIL), which has an attractive anticancer potential dueto its cancer cell-selective proapoptotic action but is often limited by thedevelopment of TRAIL-resistance in many human tumors. The mechanisms wherebytanshinones overcome TRAIL resistance and the potential translation of tanshinonesto TRAIL-based cancer remedies are also discussed herein.

Bottom Line: Combining TRAIL with agents that reverse resistance to it has proved promising in the sensitization of TRAIL-induced apoptosis.Noteworthy, natural compounds have already been validated as potential resources for TRAIL sensitizers.In this review, we focus on the recently identified TRAILsensitizing effect of tanshinones, the anticancer ingredients of the medicinal plant Salvia miltiorrhiza (Danshen in Chinese).

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, 406, Taichung, Taiwan.

ABSTRACT
An ideal cancer therapy specifically targets cancer cells while sparing normal tissues. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) elicits apoptosis by engaging its cognate death receptors (DRs-namely, DR4 and DR5. The cancer cell-selective proapoptotic action of TRAIL is highly attractive for cancer therapy, but clinical application of TRAIL is rather limited due to tumors' inherent or acquired TRAIL resistance. Combining TRAIL with agents that reverse resistance to it has proved promising in the sensitization of TRAIL-induced apoptosis. Noteworthy, natural compounds have already been validated as potential resources for TRAIL sensitizers. In this review, we focus on the recently identified TRAILsensitizing effect of tanshinones, the anticancer ingredients of the medicinal plant Salvia miltiorrhiza (Danshen in Chinese). Research from our laboratories and others have revealed the synergy of a tanshinones-TRAIL combination in diverse types of cancer cells through up-regulation of DR5 and/or down-regulation of antiapoptotic proteins such as survivin. Thus, in addition to their anticancer mechanisms, tanshinones as TRAIL sensitizers hold great potential to be translated to TRAIL-based therapeutic modalities for combatting cancer.

No MeSH data available.


Related in: MedlinePlus