Limits...
Short treatment time and excellent treatment outcome in accelerated hyperfractionated radiotherapy for T1 glottic cancer.

Tamaki Y, Hieda Y, Yoshida R, Yoshizako T, Fuchiwaki T, Aoi N, Sekihara K, Kitajima K, Kawauchi H, Kitagaki H, Sasaki R, Inomata T - Nagoya J Med Sci (2015)

Bottom Line: A complete response was observed in all patients.As late toxicity, grade 2 laryngeal edema and grade 1 laryngeal hemorrhage were observed in 1 patient each, but no serious events such as laryngeal necrosis or laryngeal stenosis were observed.In conclusion, this treatment method brings excellent outcome and will substantially reduce the treatment duration among patients who need to stay at nearby hotels while undergoing treatment at hospitals in rural areas.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Shimane University School of Medicine, Izumo, Japan.

ABSTRACT
Accelerated hyperfractionated radiotherapy was performed as treatment for patients with T1 glottic cancer, and its utility was evaluated based on treatment outcomes and adverse effects. Fifty-eight men who had undergone radiotherapy were retrospectively reviewed. Tumor classification was Tis in 4 patients, T1a in 38, and T1b in 16. Histological examination revealed squamous cell carcinoma in 55 patients. Travel time from home to hospital was 0-1 hour for 24 patients, 1-2 hours for 9, and >2 hours for 25. Laser vaporization was performed prior to radiotherapy in 38 patients, and 19 patients received concurrent chemotherapy with an agent such as S-1. Patients were irradiated twice daily using an irradiation container. Most patients received a dose of 1.5 Gy/fraction up to a total of 60 Gy. The median overall treatment time was 30 days, with a median observation period of 59.6 months. A complete response was observed in all patients. The 5-year overall survival, disease-free survival, and local control rates were 97.2%, 93.2%, and 97.8%, respectively. Although grade 3 pharyngeal mucositis was observed in 2 patients, there were no other grade 3 or higher acute adverse events. As late toxicity, grade 2 laryngeal edema and grade 1 laryngeal hemorrhage were observed in 1 patient each, but no serious events such as laryngeal necrosis or laryngeal stenosis were observed. In conclusion, this treatment method brings excellent outcome and will substantially reduce the treatment duration among patients who need to stay at nearby hotels while undergoing treatment at hospitals in rural areas.

No MeSH data available.


Related in: MedlinePlus

Kaplan-Meier analysis of local control in patients with T1 glottic cancer
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4664590&req=5

fig3: Kaplan-Meier analysis of local control in patients with T1 glottic cancer

Mentions: The median OTT was 30 days (range, 26–45 days), and the median follow-up duration was 59.6 months. At the response evaluation after radiotherapy, no tumors were observed in any of the patients, indicating a complete response in all cases. As shown in Figure 1, 5-year and 7-year OS were 97.2% and 86.1%, respectively, while 5-year and 7-year DFS were 93.2% and 82.2%, respectively (Fig. 2). In addition, 5-year and 7-year LCR were both 97.8% (Fig. 3), and 5-year and 7-year CSS were both 100%. During follow up, 8 (13.8%) patients developed second malignancy: gastric, esophageal, and lung cancer in 2 patients each and bronchial and gallbladder cancer in 1 patient each. Seven (12.1%) of the 58 patients died during the observation period, but none due to glottic cancer (the primary cancer), even though 3 died of other cancer. The remaining 4 patients died of other disease: pneumonia in 2 cases and acute exacerbation of chronic hepatitis B and chronic obstructive pulmonary disease in 1 case each.


Short treatment time and excellent treatment outcome in accelerated hyperfractionated radiotherapy for T1 glottic cancer.

Tamaki Y, Hieda Y, Yoshida R, Yoshizako T, Fuchiwaki T, Aoi N, Sekihara K, Kitajima K, Kawauchi H, Kitagaki H, Sasaki R, Inomata T - Nagoya J Med Sci (2015)

Kaplan-Meier analysis of local control in patients with T1 glottic cancer
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664590&req=5

fig3: Kaplan-Meier analysis of local control in patients with T1 glottic cancer
Mentions: The median OTT was 30 days (range, 26–45 days), and the median follow-up duration was 59.6 months. At the response evaluation after radiotherapy, no tumors were observed in any of the patients, indicating a complete response in all cases. As shown in Figure 1, 5-year and 7-year OS were 97.2% and 86.1%, respectively, while 5-year and 7-year DFS were 93.2% and 82.2%, respectively (Fig. 2). In addition, 5-year and 7-year LCR were both 97.8% (Fig. 3), and 5-year and 7-year CSS were both 100%. During follow up, 8 (13.8%) patients developed second malignancy: gastric, esophageal, and lung cancer in 2 patients each and bronchial and gallbladder cancer in 1 patient each. Seven (12.1%) of the 58 patients died during the observation period, but none due to glottic cancer (the primary cancer), even though 3 died of other cancer. The remaining 4 patients died of other disease: pneumonia in 2 cases and acute exacerbation of chronic hepatitis B and chronic obstructive pulmonary disease in 1 case each.

Bottom Line: A complete response was observed in all patients.As late toxicity, grade 2 laryngeal edema and grade 1 laryngeal hemorrhage were observed in 1 patient each, but no serious events such as laryngeal necrosis or laryngeal stenosis were observed.In conclusion, this treatment method brings excellent outcome and will substantially reduce the treatment duration among patients who need to stay at nearby hotels while undergoing treatment at hospitals in rural areas.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Shimane University School of Medicine, Izumo, Japan.

ABSTRACT
Accelerated hyperfractionated radiotherapy was performed as treatment for patients with T1 glottic cancer, and its utility was evaluated based on treatment outcomes and adverse effects. Fifty-eight men who had undergone radiotherapy were retrospectively reviewed. Tumor classification was Tis in 4 patients, T1a in 38, and T1b in 16. Histological examination revealed squamous cell carcinoma in 55 patients. Travel time from home to hospital was 0-1 hour for 24 patients, 1-2 hours for 9, and >2 hours for 25. Laser vaporization was performed prior to radiotherapy in 38 patients, and 19 patients received concurrent chemotherapy with an agent such as S-1. Patients were irradiated twice daily using an irradiation container. Most patients received a dose of 1.5 Gy/fraction up to a total of 60 Gy. The median overall treatment time was 30 days, with a median observation period of 59.6 months. A complete response was observed in all patients. The 5-year overall survival, disease-free survival, and local control rates were 97.2%, 93.2%, and 97.8%, respectively. Although grade 3 pharyngeal mucositis was observed in 2 patients, there were no other grade 3 or higher acute adverse events. As late toxicity, grade 2 laryngeal edema and grade 1 laryngeal hemorrhage were observed in 1 patient each, but no serious events such as laryngeal necrosis or laryngeal stenosis were observed. In conclusion, this treatment method brings excellent outcome and will substantially reduce the treatment duration among patients who need to stay at nearby hotels while undergoing treatment at hospitals in rural areas.

No MeSH data available.


Related in: MedlinePlus