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Transformation rate between ferritin and hemosiderin assayed by serum ferritin kinetics in patients with normal iron stores and iron overload.

Saito H, Hayashi H - Nagoya J Med Sci (2015)

Bottom Line: The transformation rate between ferritin and hemosiderin is motivated by the potential difference between them.Radio-iron fixation on the iron storing tissue in iron overload was larger than that in normal subjects by ferrokinetics.The characteristics of iron turnover between ferritin and hemosiderin were disclosed from the correlation between transformation rate and ferritin iron, hemosiderin iron or total iron stores.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Kawamura Hospital, Gifu, Japan.

ABSTRACT
Ferritin iron, hemosiderin iron, total iron stores and transformation rate were determined by serum ferritin kinetics. The transformation rate between ferritin and hemosiderin is motivated by the potential difference between them. The transformer determines transformation rate according to the potential difference in iron mobilization and deposition. The correlations between transformation rate and iron stores were studied in 11 patients with chronic hepatitis C (CHC), 1 patent with treated iron deficiency anemia (TIDA), 9 patients with hereditary hemochromatosis (HH) and 4 patients with transfusion-dependent anemia (TD). The power regression curve of approximation showed an inverse correlation between transformation rate and ferritin iron, hemosiderin iron in part and total iron stores in HH. Such an inverse correlation between transformation rate and iron stores implies that the larger the amount of iron stores, the smaller the transformation of iron stores. On the other hand, a minimal inverse correlation between transformation rate and ferritin iron and no correlation between transformation rate and hemosiderin iron or total iron stores in CHC indicate the derangement of storage iron metabolism in the cells with CHC. Radio-iron fixation on the iron storing tissue in iron overload was larger than that in normal subjects by ferrokinetics. This is consistent with the inverse correlation between transformation rate and total iron stores in HH. The characteristics of iron turnover between ferritin and hemosiderin were disclosed from the correlation between transformation rate and ferritin iron, hemosiderin iron or total iron stores.

No MeSH data available.


Related in: MedlinePlus

Two power regression curves resembling one another with an inverse correlation between transformation rates and pre-existing total iron stores in hereditary hemochromatosis (HH),5-7) and between transformation rate and final total iron stores in transfusion-dependent anemia (TD) are shown.The transformation rate for HH is proportional to the –1.1th power of pre-existing total iron stores, and that for TD is proportional to the –0.72th power of final total iron stores.
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fig8: Two power regression curves resembling one another with an inverse correlation between transformation rates and pre-existing total iron stores in hereditary hemochromatosis (HH),5-7) and between transformation rate and final total iron stores in transfusion-dependent anemia (TD) are shown.The transformation rate for HH is proportional to the –1.1th power of pre-existing total iron stores, and that for TD is proportional to the –0.72th power of final total iron stores.

Mentions: Two curves of HH and TD showing an inverse correlation between transformation rate and total iron stores are illustrated in Fig. 8.


Transformation rate between ferritin and hemosiderin assayed by serum ferritin kinetics in patients with normal iron stores and iron overload.

Saito H, Hayashi H - Nagoya J Med Sci (2015)

Two power regression curves resembling one another with an inverse correlation between transformation rates and pre-existing total iron stores in hereditary hemochromatosis (HH),5-7) and between transformation rate and final total iron stores in transfusion-dependent anemia (TD) are shown.The transformation rate for HH is proportional to the –1.1th power of pre-existing total iron stores, and that for TD is proportional to the –0.72th power of final total iron stores.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664589&req=5

fig8: Two power regression curves resembling one another with an inverse correlation between transformation rates and pre-existing total iron stores in hereditary hemochromatosis (HH),5-7) and between transformation rate and final total iron stores in transfusion-dependent anemia (TD) are shown.The transformation rate for HH is proportional to the –1.1th power of pre-existing total iron stores, and that for TD is proportional to the –0.72th power of final total iron stores.
Mentions: Two curves of HH and TD showing an inverse correlation between transformation rate and total iron stores are illustrated in Fig. 8.

Bottom Line: The transformation rate between ferritin and hemosiderin is motivated by the potential difference between them.Radio-iron fixation on the iron storing tissue in iron overload was larger than that in normal subjects by ferrokinetics.The characteristics of iron turnover between ferritin and hemosiderin were disclosed from the correlation between transformation rate and ferritin iron, hemosiderin iron or total iron stores.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Kawamura Hospital, Gifu, Japan.

ABSTRACT
Ferritin iron, hemosiderin iron, total iron stores and transformation rate were determined by serum ferritin kinetics. The transformation rate between ferritin and hemosiderin is motivated by the potential difference between them. The transformer determines transformation rate according to the potential difference in iron mobilization and deposition. The correlations between transformation rate and iron stores were studied in 11 patients with chronic hepatitis C (CHC), 1 patent with treated iron deficiency anemia (TIDA), 9 patients with hereditary hemochromatosis (HH) and 4 patients with transfusion-dependent anemia (TD). The power regression curve of approximation showed an inverse correlation between transformation rate and ferritin iron, hemosiderin iron in part and total iron stores in HH. Such an inverse correlation between transformation rate and iron stores implies that the larger the amount of iron stores, the smaller the transformation of iron stores. On the other hand, a minimal inverse correlation between transformation rate and ferritin iron and no correlation between transformation rate and hemosiderin iron or total iron stores in CHC indicate the derangement of storage iron metabolism in the cells with CHC. Radio-iron fixation on the iron storing tissue in iron overload was larger than that in normal subjects by ferrokinetics. This is consistent with the inverse correlation between transformation rate and total iron stores in HH. The characteristics of iron turnover between ferritin and hemosiderin were disclosed from the correlation between transformation rate and ferritin iron, hemosiderin iron or total iron stores.

No MeSH data available.


Related in: MedlinePlus