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Transformation rate between ferritin and hemosiderin assayed by serum ferritin kinetics in patients with normal iron stores and iron overload.

Saito H, Hayashi H - Nagoya J Med Sci (2015)

Bottom Line: The transformation rate between ferritin and hemosiderin is motivated by the potential difference between them.Radio-iron fixation on the iron storing tissue in iron overload was larger than that in normal subjects by ferrokinetics.The characteristics of iron turnover between ferritin and hemosiderin were disclosed from the correlation between transformation rate and ferritin iron, hemosiderin iron or total iron stores.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Kawamura Hospital, Gifu, Japan.

ABSTRACT
Ferritin iron, hemosiderin iron, total iron stores and transformation rate were determined by serum ferritin kinetics. The transformation rate between ferritin and hemosiderin is motivated by the potential difference between them. The transformer determines transformation rate according to the potential difference in iron mobilization and deposition. The correlations between transformation rate and iron stores were studied in 11 patients with chronic hepatitis C (CHC), 1 patent with treated iron deficiency anemia (TIDA), 9 patients with hereditary hemochromatosis (HH) and 4 patients with transfusion-dependent anemia (TD). The power regression curve of approximation showed an inverse correlation between transformation rate and ferritin iron, hemosiderin iron in part and total iron stores in HH. Such an inverse correlation between transformation rate and iron stores implies that the larger the amount of iron stores, the smaller the transformation of iron stores. On the other hand, a minimal inverse correlation between transformation rate and ferritin iron and no correlation between transformation rate and hemosiderin iron or total iron stores in CHC indicate the derangement of storage iron metabolism in the cells with CHC. Radio-iron fixation on the iron storing tissue in iron overload was larger than that in normal subjects by ferrokinetics. This is consistent with the inverse correlation between transformation rate and total iron stores in HH. The characteristics of iron turnover between ferritin and hemosiderin were disclosed from the correlation between transformation rate and ferritin iron, hemosiderin iron or total iron stores.

No MeSH data available.


Related in: MedlinePlus

No correlation is shown between turnover rates and pre-existing hemosiderin iron in 7 cases with hereditary hemochromatosis (HH)5-7) with high grade iron overload. However, 2 HH cases (# 8 and 9) with low grade iron overload showed high transformation rates; 0.3 and 0.5 each as shown in Table 2.
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fig6a: No correlation is shown between turnover rates and pre-existing hemosiderin iron in 7 cases with hereditary hemochromatosis (HH)5-7) with high grade iron overload. However, 2 HH cases (# 8 and 9) with low grade iron overload showed high transformation rates; 0.3 and 0.5 each as shown in Table 2.

Mentions: No correlation between transformation rate and hemosiderin iron was observed in 9 HH cases as shown in Fig. 6a. However, in the 2 HH cases (#8 and 9), transformation rates (0.30 and 0.50) were high and total iron stores (7 and 4 g) were low (Table 2. The power regression curve of approximation between transformation rate and hemosiderin iron demonstrated a close inverse correlation from a group of 5 HH cases as shown in Fig. 6b. Other 4 HH cases were excluded, because they had an unusually high ferritin per hemosiderin iron ratio in iron overload1, 17, 19, 20) as explained later in the Discussion on the transformation rate.


Transformation rate between ferritin and hemosiderin assayed by serum ferritin kinetics in patients with normal iron stores and iron overload.

Saito H, Hayashi H - Nagoya J Med Sci (2015)

No correlation is shown between turnover rates and pre-existing hemosiderin iron in 7 cases with hereditary hemochromatosis (HH)5-7) with high grade iron overload. However, 2 HH cases (# 8 and 9) with low grade iron overload showed high transformation rates; 0.3 and 0.5 each as shown in Table 2.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664589&req=5

fig6a: No correlation is shown between turnover rates and pre-existing hemosiderin iron in 7 cases with hereditary hemochromatosis (HH)5-7) with high grade iron overload. However, 2 HH cases (# 8 and 9) with low grade iron overload showed high transformation rates; 0.3 and 0.5 each as shown in Table 2.
Mentions: No correlation between transformation rate and hemosiderin iron was observed in 9 HH cases as shown in Fig. 6a. However, in the 2 HH cases (#8 and 9), transformation rates (0.30 and 0.50) were high and total iron stores (7 and 4 g) were low (Table 2. The power regression curve of approximation between transformation rate and hemosiderin iron demonstrated a close inverse correlation from a group of 5 HH cases as shown in Fig. 6b. Other 4 HH cases were excluded, because they had an unusually high ferritin per hemosiderin iron ratio in iron overload1, 17, 19, 20) as explained later in the Discussion on the transformation rate.

Bottom Line: The transformation rate between ferritin and hemosiderin is motivated by the potential difference between them.Radio-iron fixation on the iron storing tissue in iron overload was larger than that in normal subjects by ferrokinetics.The characteristics of iron turnover between ferritin and hemosiderin were disclosed from the correlation between transformation rate and ferritin iron, hemosiderin iron or total iron stores.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Kawamura Hospital, Gifu, Japan.

ABSTRACT
Ferritin iron, hemosiderin iron, total iron stores and transformation rate were determined by serum ferritin kinetics. The transformation rate between ferritin and hemosiderin is motivated by the potential difference between them. The transformer determines transformation rate according to the potential difference in iron mobilization and deposition. The correlations between transformation rate and iron stores were studied in 11 patients with chronic hepatitis C (CHC), 1 patent with treated iron deficiency anemia (TIDA), 9 patients with hereditary hemochromatosis (HH) and 4 patients with transfusion-dependent anemia (TD). The power regression curve of approximation showed an inverse correlation between transformation rate and ferritin iron, hemosiderin iron in part and total iron stores in HH. Such an inverse correlation between transformation rate and iron stores implies that the larger the amount of iron stores, the smaller the transformation of iron stores. On the other hand, a minimal inverse correlation between transformation rate and ferritin iron and no correlation between transformation rate and hemosiderin iron or total iron stores in CHC indicate the derangement of storage iron metabolism in the cells with CHC. Radio-iron fixation on the iron storing tissue in iron overload was larger than that in normal subjects by ferrokinetics. This is consistent with the inverse correlation between transformation rate and total iron stores in HH. The characteristics of iron turnover between ferritin and hemosiderin were disclosed from the correlation between transformation rate and ferritin iron, hemosiderin iron or total iron stores.

No MeSH data available.


Related in: MedlinePlus