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Transformation rate between ferritin and hemosiderin assayed by serum ferritin kinetics in patients with normal iron stores and iron overload.

Saito H, Hayashi H - Nagoya J Med Sci (2015)

Bottom Line: The transformation rate between ferritin and hemosiderin is motivated by the potential difference between them.Radio-iron fixation on the iron storing tissue in iron overload was larger than that in normal subjects by ferrokinetics.The characteristics of iron turnover between ferritin and hemosiderin were disclosed from the correlation between transformation rate and ferritin iron, hemosiderin iron or total iron stores.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Kawamura Hospital, Gifu, Japan.

ABSTRACT
Ferritin iron, hemosiderin iron, total iron stores and transformation rate were determined by serum ferritin kinetics. The transformation rate between ferritin and hemosiderin is motivated by the potential difference between them. The transformer determines transformation rate according to the potential difference in iron mobilization and deposition. The correlations between transformation rate and iron stores were studied in 11 patients with chronic hepatitis C (CHC), 1 patent with treated iron deficiency anemia (TIDA), 9 patients with hereditary hemochromatosis (HH) and 4 patients with transfusion-dependent anemia (TD). The power regression curve of approximation showed an inverse correlation between transformation rate and ferritin iron, hemosiderin iron in part and total iron stores in HH. Such an inverse correlation between transformation rate and iron stores implies that the larger the amount of iron stores, the smaller the transformation of iron stores. On the other hand, a minimal inverse correlation between transformation rate and ferritin iron and no correlation between transformation rate and hemosiderin iron or total iron stores in CHC indicate the derangement of storage iron metabolism in the cells with CHC. Radio-iron fixation on the iron storing tissue in iron overload was larger than that in normal subjects by ferrokinetics. This is consistent with the inverse correlation between transformation rate and total iron stores in HH. The characteristics of iron turnover between ferritin and hemosiderin were disclosed from the correlation between transformation rate and ferritin iron, hemosiderin iron or total iron stores.

No MeSH data available.


Related in: MedlinePlus

Serum ferritin increase curve following the repetitive constant blood transfusion in patient #13 with transfusion-dependent anemia (TD) with pre-transfusional iron stores, which were supposed to be the normal level from 81 ng/ml initial serum ferritin.The increasing green curve was selected from serum ferritin assay-dots as mentioned in the Legend of Fig. 2. Increasing green convex curve indicates the sum of increasing component and decreasing (transforming) component of serum ferritin. The red straight line indicates the curve of a net serum ferritin increasing without decreasing component. At an amount of iron stores shown on the horizontal scale, a serum ferritin value on yellow curve (cumulative transformed ferritin iron = cumulative hemosiderin iron increased) is obtained by subtracting a value on green curve (sum of increasing and decreasing ferritin iron) vertically from a value on red line indicating cumulative net ferritin iron. The cumulative amount of hemosiderin iron transformed was obtained by subtracting the remaining tissue ferritin iron from the sum of ferritin iron synthesized by iron addition.
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fig3: Serum ferritin increase curve following the repetitive constant blood transfusion in patient #13 with transfusion-dependent anemia (TD) with pre-transfusional iron stores, which were supposed to be the normal level from 81 ng/ml initial serum ferritin.The increasing green curve was selected from serum ferritin assay-dots as mentioned in the Legend of Fig. 2. Increasing green convex curve indicates the sum of increasing component and decreasing (transforming) component of serum ferritin. The red straight line indicates the curve of a net serum ferritin increasing without decreasing component. At an amount of iron stores shown on the horizontal scale, a serum ferritin value on yellow curve (cumulative transformed ferritin iron = cumulative hemosiderin iron increased) is obtained by subtracting a value on green curve (sum of increasing and decreasing ferritin iron) vertically from a value on red line indicating cumulative net ferritin iron. The cumulative amount of hemosiderin iron transformed was obtained by subtracting the remaining tissue ferritin iron from the sum of ferritin iron synthesized by iron addition.

Mentions: The serum ferritin increase curve used for determining the amount of ferritin iron, hemosiderin iron and transformed ferritin iron in patient #13 with transfusion-dependent anemia (TD) is illustrated in Fig. 3.


Transformation rate between ferritin and hemosiderin assayed by serum ferritin kinetics in patients with normal iron stores and iron overload.

Saito H, Hayashi H - Nagoya J Med Sci (2015)

Serum ferritin increase curve following the repetitive constant blood transfusion in patient #13 with transfusion-dependent anemia (TD) with pre-transfusional iron stores, which were supposed to be the normal level from 81 ng/ml initial serum ferritin.The increasing green curve was selected from serum ferritin assay-dots as mentioned in the Legend of Fig. 2. Increasing green convex curve indicates the sum of increasing component and decreasing (transforming) component of serum ferritin. The red straight line indicates the curve of a net serum ferritin increasing without decreasing component. At an amount of iron stores shown on the horizontal scale, a serum ferritin value on yellow curve (cumulative transformed ferritin iron = cumulative hemosiderin iron increased) is obtained by subtracting a value on green curve (sum of increasing and decreasing ferritin iron) vertically from a value on red line indicating cumulative net ferritin iron. The cumulative amount of hemosiderin iron transformed was obtained by subtracting the remaining tissue ferritin iron from the sum of ferritin iron synthesized by iron addition.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664589&req=5

fig3: Serum ferritin increase curve following the repetitive constant blood transfusion in patient #13 with transfusion-dependent anemia (TD) with pre-transfusional iron stores, which were supposed to be the normal level from 81 ng/ml initial serum ferritin.The increasing green curve was selected from serum ferritin assay-dots as mentioned in the Legend of Fig. 2. Increasing green convex curve indicates the sum of increasing component and decreasing (transforming) component of serum ferritin. The red straight line indicates the curve of a net serum ferritin increasing without decreasing component. At an amount of iron stores shown on the horizontal scale, a serum ferritin value on yellow curve (cumulative transformed ferritin iron = cumulative hemosiderin iron increased) is obtained by subtracting a value on green curve (sum of increasing and decreasing ferritin iron) vertically from a value on red line indicating cumulative net ferritin iron. The cumulative amount of hemosiderin iron transformed was obtained by subtracting the remaining tissue ferritin iron from the sum of ferritin iron synthesized by iron addition.
Mentions: The serum ferritin increase curve used for determining the amount of ferritin iron, hemosiderin iron and transformed ferritin iron in patient #13 with transfusion-dependent anemia (TD) is illustrated in Fig. 3.

Bottom Line: The transformation rate between ferritin and hemosiderin is motivated by the potential difference between them.Radio-iron fixation on the iron storing tissue in iron overload was larger than that in normal subjects by ferrokinetics.The characteristics of iron turnover between ferritin and hemosiderin were disclosed from the correlation between transformation rate and ferritin iron, hemosiderin iron or total iron stores.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Kawamura Hospital, Gifu, Japan.

ABSTRACT
Ferritin iron, hemosiderin iron, total iron stores and transformation rate were determined by serum ferritin kinetics. The transformation rate between ferritin and hemosiderin is motivated by the potential difference between them. The transformer determines transformation rate according to the potential difference in iron mobilization and deposition. The correlations between transformation rate and iron stores were studied in 11 patients with chronic hepatitis C (CHC), 1 patent with treated iron deficiency anemia (TIDA), 9 patients with hereditary hemochromatosis (HH) and 4 patients with transfusion-dependent anemia (TD). The power regression curve of approximation showed an inverse correlation between transformation rate and ferritin iron, hemosiderin iron in part and total iron stores in HH. Such an inverse correlation between transformation rate and iron stores implies that the larger the amount of iron stores, the smaller the transformation of iron stores. On the other hand, a minimal inverse correlation between transformation rate and ferritin iron and no correlation between transformation rate and hemosiderin iron or total iron stores in CHC indicate the derangement of storage iron metabolism in the cells with CHC. Radio-iron fixation on the iron storing tissue in iron overload was larger than that in normal subjects by ferrokinetics. This is consistent with the inverse correlation between transformation rate and total iron stores in HH. The characteristics of iron turnover between ferritin and hemosiderin were disclosed from the correlation between transformation rate and ferritin iron, hemosiderin iron or total iron stores.

No MeSH data available.


Related in: MedlinePlus