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Transformation rate between ferritin and hemosiderin assayed by serum ferritin kinetics in patients with normal iron stores and iron overload.

Saito H, Hayashi H - Nagoya J Med Sci (2015)

Bottom Line: The transformation rate between ferritin and hemosiderin is motivated by the potential difference between them.Radio-iron fixation on the iron storing tissue in iron overload was larger than that in normal subjects by ferrokinetics.The characteristics of iron turnover between ferritin and hemosiderin were disclosed from the correlation between transformation rate and ferritin iron, hemosiderin iron or total iron stores.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Kawamura Hospital, Gifu, Japan.

ABSTRACT
Ferritin iron, hemosiderin iron, total iron stores and transformation rate were determined by serum ferritin kinetics. The transformation rate between ferritin and hemosiderin is motivated by the potential difference between them. The transformer determines transformation rate according to the potential difference in iron mobilization and deposition. The correlations between transformation rate and iron stores were studied in 11 patients with chronic hepatitis C (CHC), 1 patent with treated iron deficiency anemia (TIDA), 9 patients with hereditary hemochromatosis (HH) and 4 patients with transfusion-dependent anemia (TD). The power regression curve of approximation showed an inverse correlation between transformation rate and ferritin iron, hemosiderin iron in part and total iron stores in HH. Such an inverse correlation between transformation rate and iron stores implies that the larger the amount of iron stores, the smaller the transformation of iron stores. On the other hand, a minimal inverse correlation between transformation rate and ferritin iron and no correlation between transformation rate and hemosiderin iron or total iron stores in CHC indicate the derangement of storage iron metabolism in the cells with CHC. Radio-iron fixation on the iron storing tissue in iron overload was larger than that in normal subjects by ferrokinetics. This is consistent with the inverse correlation between transformation rate and total iron stores in HH. The characteristics of iron turnover between ferritin and hemosiderin were disclosed from the correlation between transformation rate and ferritin iron, hemosiderin iron or total iron stores.

No MeSH data available.


Related in: MedlinePlus

Serum ferritin decrease curve in patient with treated iron deficiency anemia (TIDA), whose hemoglobin level was normalized after the intravenous iron administration. The rest of administered iron after the use for hemoglobin recovery, 1.7 gram of iron was stored temporarily. The patient fell into iron deficiency anemia again by persistent intestinal blood loss. The best fit green curve was selected by computer simulation to the series of decreasing serum ferritin assay-dots.Decreasing concave green curve indicates the sum of decreasing component and increasing (recovering) component of serum ferritin. Red straight line indicates the curve of a net serum ferritin decreasing without increasing component. Yellow increasing curve indicates the cumulative serum ferritin recovered (increased) in the course of iron loss by bleeding. The intersection of the red straight line and the horizontal axis at 0.5 g indicates the sum of tissue ferritin iron removed, excluding the tissue ferritin iron increased. The end point of decreasing concave green curve on the horizontal axis at 1.7 g indicates the amount of total iron stores removed. The amount of hemosiderin iron removed was obtained by subtracting the sum of tissue ferritin iron removed from total iron stores removed (1.7 – 0.5 = 1.2 g).9)
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fig2: Serum ferritin decrease curve in patient with treated iron deficiency anemia (TIDA), whose hemoglobin level was normalized after the intravenous iron administration. The rest of administered iron after the use for hemoglobin recovery, 1.7 gram of iron was stored temporarily. The patient fell into iron deficiency anemia again by persistent intestinal blood loss. The best fit green curve was selected by computer simulation to the series of decreasing serum ferritin assay-dots.Decreasing concave green curve indicates the sum of decreasing component and increasing (recovering) component of serum ferritin. Red straight line indicates the curve of a net serum ferritin decreasing without increasing component. Yellow increasing curve indicates the cumulative serum ferritin recovered (increased) in the course of iron loss by bleeding. The intersection of the red straight line and the horizontal axis at 0.5 g indicates the sum of tissue ferritin iron removed, excluding the tissue ferritin iron increased. The end point of decreasing concave green curve on the horizontal axis at 1.7 g indicates the amount of total iron stores removed. The amount of hemosiderin iron removed was obtained by subtracting the sum of tissue ferritin iron removed from total iron stores removed (1.7 – 0.5 = 1.2 g).9)

Mentions: The serum ferritin decrease curve used for determining the amount of ferritin iron, hemosiderin iron and recovered ferritin iron in patient #25 with treated iron deficiency anemia (TIDA) is illustrated in Fig. 2.


Transformation rate between ferritin and hemosiderin assayed by serum ferritin kinetics in patients with normal iron stores and iron overload.

Saito H, Hayashi H - Nagoya J Med Sci (2015)

Serum ferritin decrease curve in patient with treated iron deficiency anemia (TIDA), whose hemoglobin level was normalized after the intravenous iron administration. The rest of administered iron after the use for hemoglobin recovery, 1.7 gram of iron was stored temporarily. The patient fell into iron deficiency anemia again by persistent intestinal blood loss. The best fit green curve was selected by computer simulation to the series of decreasing serum ferritin assay-dots.Decreasing concave green curve indicates the sum of decreasing component and increasing (recovering) component of serum ferritin. Red straight line indicates the curve of a net serum ferritin decreasing without increasing component. Yellow increasing curve indicates the cumulative serum ferritin recovered (increased) in the course of iron loss by bleeding. The intersection of the red straight line and the horizontal axis at 0.5 g indicates the sum of tissue ferritin iron removed, excluding the tissue ferritin iron increased. The end point of decreasing concave green curve on the horizontal axis at 1.7 g indicates the amount of total iron stores removed. The amount of hemosiderin iron removed was obtained by subtracting the sum of tissue ferritin iron removed from total iron stores removed (1.7 – 0.5 = 1.2 g).9)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664589&req=5

fig2: Serum ferritin decrease curve in patient with treated iron deficiency anemia (TIDA), whose hemoglobin level was normalized after the intravenous iron administration. The rest of administered iron after the use for hemoglobin recovery, 1.7 gram of iron was stored temporarily. The patient fell into iron deficiency anemia again by persistent intestinal blood loss. The best fit green curve was selected by computer simulation to the series of decreasing serum ferritin assay-dots.Decreasing concave green curve indicates the sum of decreasing component and increasing (recovering) component of serum ferritin. Red straight line indicates the curve of a net serum ferritin decreasing without increasing component. Yellow increasing curve indicates the cumulative serum ferritin recovered (increased) in the course of iron loss by bleeding. The intersection of the red straight line and the horizontal axis at 0.5 g indicates the sum of tissue ferritin iron removed, excluding the tissue ferritin iron increased. The end point of decreasing concave green curve on the horizontal axis at 1.7 g indicates the amount of total iron stores removed. The amount of hemosiderin iron removed was obtained by subtracting the sum of tissue ferritin iron removed from total iron stores removed (1.7 – 0.5 = 1.2 g).9)
Mentions: The serum ferritin decrease curve used for determining the amount of ferritin iron, hemosiderin iron and recovered ferritin iron in patient #25 with treated iron deficiency anemia (TIDA) is illustrated in Fig. 2.

Bottom Line: The transformation rate between ferritin and hemosiderin is motivated by the potential difference between them.Radio-iron fixation on the iron storing tissue in iron overload was larger than that in normal subjects by ferrokinetics.The characteristics of iron turnover between ferritin and hemosiderin were disclosed from the correlation between transformation rate and ferritin iron, hemosiderin iron or total iron stores.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Kawamura Hospital, Gifu, Japan.

ABSTRACT
Ferritin iron, hemosiderin iron, total iron stores and transformation rate were determined by serum ferritin kinetics. The transformation rate between ferritin and hemosiderin is motivated by the potential difference between them. The transformer determines transformation rate according to the potential difference in iron mobilization and deposition. The correlations between transformation rate and iron stores were studied in 11 patients with chronic hepatitis C (CHC), 1 patent with treated iron deficiency anemia (TIDA), 9 patients with hereditary hemochromatosis (HH) and 4 patients with transfusion-dependent anemia (TD). The power regression curve of approximation showed an inverse correlation between transformation rate and ferritin iron, hemosiderin iron in part and total iron stores in HH. Such an inverse correlation between transformation rate and iron stores implies that the larger the amount of iron stores, the smaller the transformation of iron stores. On the other hand, a minimal inverse correlation between transformation rate and ferritin iron and no correlation between transformation rate and hemosiderin iron or total iron stores in CHC indicate the derangement of storage iron metabolism in the cells with CHC. Radio-iron fixation on the iron storing tissue in iron overload was larger than that in normal subjects by ferrokinetics. This is consistent with the inverse correlation between transformation rate and total iron stores in HH. The characteristics of iron turnover between ferritin and hemosiderin were disclosed from the correlation between transformation rate and ferritin iron, hemosiderin iron or total iron stores.

No MeSH data available.


Related in: MedlinePlus