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Transformation rate between ferritin and hemosiderin assayed by serum ferritin kinetics in patients with normal iron stores and iron overload.

Saito H, Hayashi H - Nagoya J Med Sci (2015)

Bottom Line: The transformation rate between ferritin and hemosiderin is motivated by the potential difference between them.Radio-iron fixation on the iron storing tissue in iron overload was larger than that in normal subjects by ferrokinetics.The characteristics of iron turnover between ferritin and hemosiderin were disclosed from the correlation between transformation rate and ferritin iron, hemosiderin iron or total iron stores.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Kawamura Hospital, Gifu, Japan.

ABSTRACT
Ferritin iron, hemosiderin iron, total iron stores and transformation rate were determined by serum ferritin kinetics. The transformation rate between ferritin and hemosiderin is motivated by the potential difference between them. The transformer determines transformation rate according to the potential difference in iron mobilization and deposition. The correlations between transformation rate and iron stores were studied in 11 patients with chronic hepatitis C (CHC), 1 patent with treated iron deficiency anemia (TIDA), 9 patients with hereditary hemochromatosis (HH) and 4 patients with transfusion-dependent anemia (TD). The power regression curve of approximation showed an inverse correlation between transformation rate and ferritin iron, hemosiderin iron in part and total iron stores in HH. Such an inverse correlation between transformation rate and iron stores implies that the larger the amount of iron stores, the smaller the transformation of iron stores. On the other hand, a minimal inverse correlation between transformation rate and ferritin iron and no correlation between transformation rate and hemosiderin iron or total iron stores in CHC indicate the derangement of storage iron metabolism in the cells with CHC. Radio-iron fixation on the iron storing tissue in iron overload was larger than that in normal subjects by ferrokinetics. This is consistent with the inverse correlation between transformation rate and total iron stores in HH. The characteristics of iron turnover between ferritin and hemosiderin were disclosed from the correlation between transformation rate and ferritin iron, hemosiderin iron or total iron stores.

No MeSH data available.


Related in: MedlinePlus

A model for explaining the fundamental mechanism of transformation between ferritin and hemosiderin is introduced. The left side half shows the 3 stages of iron stores increasing in iron addition, and the right side half shows the 3 stages of iron stores decreasing in iron removal. The top stage of left and right side figures shows the equilibrium of potential between ferritin iron pool and hemosiderin iron pool. Ferritin iron is transformed into hemosiderin iron in iron addition or hemosiderin iron is transformed into ferritin iron in iron removal to maintain the equilibrium between ferritin iron and hemosiderin iron. When ferritin iron is condensed to its saturation level by iron addition, overbalanced ferritin iron is transformed into hemosiderin iron. When ferritin iron is decreased by iron removal, hemosiderin iron is transformed into ferritin iron by mobilizing iron from hemosiderin to compensate its deficit.17, 18) The potential difference between ferritin iron pool and hemosiderin iron pool is changed in the course of iron addition or iron removal. A difference in potential level between ferritin iron pool and hemosiderin iron pool motivates the transformation of iron stores. The boundary for transformation is named "Transformer". The potential difference-dependent transformer determines transformation rate.
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fig1: A model for explaining the fundamental mechanism of transformation between ferritin and hemosiderin is introduced. The left side half shows the 3 stages of iron stores increasing in iron addition, and the right side half shows the 3 stages of iron stores decreasing in iron removal. The top stage of left and right side figures shows the equilibrium of potential between ferritin iron pool and hemosiderin iron pool. Ferritin iron is transformed into hemosiderin iron in iron addition or hemosiderin iron is transformed into ferritin iron in iron removal to maintain the equilibrium between ferritin iron and hemosiderin iron. When ferritin iron is condensed to its saturation level by iron addition, overbalanced ferritin iron is transformed into hemosiderin iron. When ferritin iron is decreased by iron removal, hemosiderin iron is transformed into ferritin iron by mobilizing iron from hemosiderin to compensate its deficit.17, 18) The potential difference between ferritin iron pool and hemosiderin iron pool is changed in the course of iron addition or iron removal. A difference in potential level between ferritin iron pool and hemosiderin iron pool motivates the transformation of iron stores. The boundary for transformation is named "Transformer". The potential difference-dependent transformer determines transformation rate.

Mentions: The amount of ferritin iron and hemosiderin iron were determined from serum ferritin decrease or increase curve17) as described in the legend of Figure 1.


Transformation rate between ferritin and hemosiderin assayed by serum ferritin kinetics in patients with normal iron stores and iron overload.

Saito H, Hayashi H - Nagoya J Med Sci (2015)

A model for explaining the fundamental mechanism of transformation between ferritin and hemosiderin is introduced. The left side half shows the 3 stages of iron stores increasing in iron addition, and the right side half shows the 3 stages of iron stores decreasing in iron removal. The top stage of left and right side figures shows the equilibrium of potential between ferritin iron pool and hemosiderin iron pool. Ferritin iron is transformed into hemosiderin iron in iron addition or hemosiderin iron is transformed into ferritin iron in iron removal to maintain the equilibrium between ferritin iron and hemosiderin iron. When ferritin iron is condensed to its saturation level by iron addition, overbalanced ferritin iron is transformed into hemosiderin iron. When ferritin iron is decreased by iron removal, hemosiderin iron is transformed into ferritin iron by mobilizing iron from hemosiderin to compensate its deficit.17, 18) The potential difference between ferritin iron pool and hemosiderin iron pool is changed in the course of iron addition or iron removal. A difference in potential level between ferritin iron pool and hemosiderin iron pool motivates the transformation of iron stores. The boundary for transformation is named "Transformer". The potential difference-dependent transformer determines transformation rate.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664589&req=5

fig1: A model for explaining the fundamental mechanism of transformation between ferritin and hemosiderin is introduced. The left side half shows the 3 stages of iron stores increasing in iron addition, and the right side half shows the 3 stages of iron stores decreasing in iron removal. The top stage of left and right side figures shows the equilibrium of potential between ferritin iron pool and hemosiderin iron pool. Ferritin iron is transformed into hemosiderin iron in iron addition or hemosiderin iron is transformed into ferritin iron in iron removal to maintain the equilibrium between ferritin iron and hemosiderin iron. When ferritin iron is condensed to its saturation level by iron addition, overbalanced ferritin iron is transformed into hemosiderin iron. When ferritin iron is decreased by iron removal, hemosiderin iron is transformed into ferritin iron by mobilizing iron from hemosiderin to compensate its deficit.17, 18) The potential difference between ferritin iron pool and hemosiderin iron pool is changed in the course of iron addition or iron removal. A difference in potential level between ferritin iron pool and hemosiderin iron pool motivates the transformation of iron stores. The boundary for transformation is named "Transformer". The potential difference-dependent transformer determines transformation rate.
Mentions: The amount of ferritin iron and hemosiderin iron were determined from serum ferritin decrease or increase curve17) as described in the legend of Figure 1.

Bottom Line: The transformation rate between ferritin and hemosiderin is motivated by the potential difference between them.Radio-iron fixation on the iron storing tissue in iron overload was larger than that in normal subjects by ferrokinetics.The characteristics of iron turnover between ferritin and hemosiderin were disclosed from the correlation between transformation rate and ferritin iron, hemosiderin iron or total iron stores.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Kawamura Hospital, Gifu, Japan.

ABSTRACT
Ferritin iron, hemosiderin iron, total iron stores and transformation rate were determined by serum ferritin kinetics. The transformation rate between ferritin and hemosiderin is motivated by the potential difference between them. The transformer determines transformation rate according to the potential difference in iron mobilization and deposition. The correlations between transformation rate and iron stores were studied in 11 patients with chronic hepatitis C (CHC), 1 patent with treated iron deficiency anemia (TIDA), 9 patients with hereditary hemochromatosis (HH) and 4 patients with transfusion-dependent anemia (TD). The power regression curve of approximation showed an inverse correlation between transformation rate and ferritin iron, hemosiderin iron in part and total iron stores in HH. Such an inverse correlation between transformation rate and iron stores implies that the larger the amount of iron stores, the smaller the transformation of iron stores. On the other hand, a minimal inverse correlation between transformation rate and ferritin iron and no correlation between transformation rate and hemosiderin iron or total iron stores in CHC indicate the derangement of storage iron metabolism in the cells with CHC. Radio-iron fixation on the iron storing tissue in iron overload was larger than that in normal subjects by ferrokinetics. This is consistent with the inverse correlation between transformation rate and total iron stores in HH. The characteristics of iron turnover between ferritin and hemosiderin were disclosed from the correlation between transformation rate and ferritin iron, hemosiderin iron or total iron stores.

No MeSH data available.


Related in: MedlinePlus