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Novel treatment options for nonmelanoma skin cancer: focus on electronic brachytherapy.

Kasper ME, Chaudhary AA - Med Devices (Auckl) (2015)

Bottom Line: Radiotherapy has a long history in the treatment of NMSC.Shortly after the discovery of X-rays and (226)Radium, physicians cured patients with NMSC using these new treatments.Both X-ray therapy and brachytherapy have evolved over the years, ultimately delivering higher cure rates and lower toxicity.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Lynn Cancer Institute at Boca Raton Regional Hospital, Boca Raton, USA ; Charles E. Schmidt College of Medicine, Florida Atlantic University, FL, USA.

ABSTRACT
Nonmelanoma skin cancer (NMSC) is an increasing health care issue in the United States, significantly affecting quality of life and impacting health care costs. Radiotherapy has a long history in the treatment of NMSC. Shortly after the discovery of X-rays and (226)Radium, physicians cured patients with NMSC using these new treatments. Both X-ray therapy and brachytherapy have evolved over the years, ultimately delivering higher cure rates and lower toxicity. Electronic brachytherapy for NMSC is based on the technical and clinical data obtained from radionuclide skin surface brachytherapy and the small skin surface applicators developed over the past 25 years. The purpose of this review is to introduce electronic brachytherapy in the context of the history, data, and utilization of traditional radiotherapy and brachytherapy.

No MeSH data available.


Related in: MedlinePlus

The Esteya® Electronic Brachytherapy System (Elekta® AB-Nucletron, Stockholm, Sweden).Note: Reproduced from Esteya.com [homepage on the Internet]. Esteya Electronic Brachytherapy for Treating Skin Cancer. Sweden: Elekta AB, 2015. Available from: http://www.esteya.com.21
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f5-mder-8-493: The Esteya® Electronic Brachytherapy System (Elekta® AB-Nucletron, Stockholm, Sweden).Note: Reproduced from Esteya.com [homepage on the Internet]. Esteya Electronic Brachytherapy for Treating Skin Cancer. Sweden: Elekta AB, 2015. Available from: http://www.esteya.com.21

Mentions: The Esteya Electronic Brachytherapy System (Elekta AB-Nucletron, Stockholm, Sweden) was developed specifically for the treatment of skin surface lesions (Figure 5).21 It consists of a treatment control panel with planning software, a treatment unit, and surface applicators. The applicator diameters for treatment are 10 mm, 15 mm, 20 mm, 25 mm, and 30 mm, and a 0 mm applicator is used for quality assurance (Figure 6).17,21 The treatment unit can generate a light field to assist in set up, but a template centering the lesion and directing placement of the applicator, as designed by the Valencia group, greatly simplifies treatment and improves accuracy (Figure 6).22 The Esteya utilizes a collimated, miniature X-ray source that has a fixed voltage of 69.5 kV. It uses a variable beam current, which is nominally set at 1.6 mA, but self adjusts to 1.0 mA for doses of 2–4 Gy and 0.5 mA for doses<2 Gy. Treatment times for surface lesions are generally 2–3 minutes, and the surface dose is 120% of the specified dose, when the specified dose is normalized to 3 mm depth. The source requires maintenance every 4,000 fractions.21,23


Novel treatment options for nonmelanoma skin cancer: focus on electronic brachytherapy.

Kasper ME, Chaudhary AA - Med Devices (Auckl) (2015)

The Esteya® Electronic Brachytherapy System (Elekta® AB-Nucletron, Stockholm, Sweden).Note: Reproduced from Esteya.com [homepage on the Internet]. Esteya Electronic Brachytherapy for Treating Skin Cancer. Sweden: Elekta AB, 2015. Available from: http://www.esteya.com.21
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664532&req=5

f5-mder-8-493: The Esteya® Electronic Brachytherapy System (Elekta® AB-Nucletron, Stockholm, Sweden).Note: Reproduced from Esteya.com [homepage on the Internet]. Esteya Electronic Brachytherapy for Treating Skin Cancer. Sweden: Elekta AB, 2015. Available from: http://www.esteya.com.21
Mentions: The Esteya Electronic Brachytherapy System (Elekta AB-Nucletron, Stockholm, Sweden) was developed specifically for the treatment of skin surface lesions (Figure 5).21 It consists of a treatment control panel with planning software, a treatment unit, and surface applicators. The applicator diameters for treatment are 10 mm, 15 mm, 20 mm, 25 mm, and 30 mm, and a 0 mm applicator is used for quality assurance (Figure 6).17,21 The treatment unit can generate a light field to assist in set up, but a template centering the lesion and directing placement of the applicator, as designed by the Valencia group, greatly simplifies treatment and improves accuracy (Figure 6).22 The Esteya utilizes a collimated, miniature X-ray source that has a fixed voltage of 69.5 kV. It uses a variable beam current, which is nominally set at 1.6 mA, but self adjusts to 1.0 mA for doses of 2–4 Gy and 0.5 mA for doses<2 Gy. Treatment times for surface lesions are generally 2–3 minutes, and the surface dose is 120% of the specified dose, when the specified dose is normalized to 3 mm depth. The source requires maintenance every 4,000 fractions.21,23

Bottom Line: Radiotherapy has a long history in the treatment of NMSC.Shortly after the discovery of X-rays and (226)Radium, physicians cured patients with NMSC using these new treatments.Both X-ray therapy and brachytherapy have evolved over the years, ultimately delivering higher cure rates and lower toxicity.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Lynn Cancer Institute at Boca Raton Regional Hospital, Boca Raton, USA ; Charles E. Schmidt College of Medicine, Florida Atlantic University, FL, USA.

ABSTRACT
Nonmelanoma skin cancer (NMSC) is an increasing health care issue in the United States, significantly affecting quality of life and impacting health care costs. Radiotherapy has a long history in the treatment of NMSC. Shortly after the discovery of X-rays and (226)Radium, physicians cured patients with NMSC using these new treatments. Both X-ray therapy and brachytherapy have evolved over the years, ultimately delivering higher cure rates and lower toxicity. Electronic brachytherapy for NMSC is based on the technical and clinical data obtained from radionuclide skin surface brachytherapy and the small skin surface applicators developed over the past 25 years. The purpose of this review is to introduce electronic brachytherapy in the context of the history, data, and utilization of traditional radiotherapy and brachytherapy.

No MeSH data available.


Related in: MedlinePlus