Limits...
Novel treatment options for nonmelanoma skin cancer: focus on electronic brachytherapy.

Kasper ME, Chaudhary AA - Med Devices (Auckl) (2015)

Bottom Line: Radiotherapy has a long history in the treatment of NMSC.Shortly after the discovery of X-rays and (226)Radium, physicians cured patients with NMSC using these new treatments.Both X-ray therapy and brachytherapy have evolved over the years, ultimately delivering higher cure rates and lower toxicity.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Lynn Cancer Institute at Boca Raton Regional Hospital, Boca Raton, USA ; Charles E. Schmidt College of Medicine, Florida Atlantic University, FL, USA.

ABSTRACT
Nonmelanoma skin cancer (NMSC) is an increasing health care issue in the United States, significantly affecting quality of life and impacting health care costs. Radiotherapy has a long history in the treatment of NMSC. Shortly after the discovery of X-rays and (226)Radium, physicians cured patients with NMSC using these new treatments. Both X-ray therapy and brachytherapy have evolved over the years, ultimately delivering higher cure rates and lower toxicity. Electronic brachytherapy for NMSC is based on the technical and clinical data obtained from radionuclide skin surface brachytherapy and the small skin surface applicators developed over the past 25 years. The purpose of this review is to introduce electronic brachytherapy in the context of the history, data, and utilization of traditional radiotherapy and brachytherapy.

No MeSH data available.


Related in: MedlinePlus

A surface applicator used for electronic brachytherapy with the Zeiss® INTRABEAM® (Carl Zeiss Surgical) PRS500 System.Note: Reproduced from Zeiss.com [homepage on the Internet]. INTRABEAM: Precision and Ease of Use. Jena, Germany: Carl Zeiss Meditec AG, 2014. Available from: http://www.zeiss.com/meditec/en_us/products-solutions/intraoperative-radiotherapy/intrabeam-for-breast-cancer/intrabeam.html. Accessed June 11, 2015.19
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4664532&req=5

f4-mder-8-493: A surface applicator used for electronic brachytherapy with the Zeiss® INTRABEAM® (Carl Zeiss Surgical) PRS500 System.Note: Reproduced from Zeiss.com [homepage on the Internet]. INTRABEAM: Precision and Ease of Use. Jena, Germany: Carl Zeiss Meditec AG, 2014. Available from: http://www.zeiss.com/meditec/en_us/products-solutions/intraoperative-radiotherapy/intrabeam-for-breast-cancer/intrabeam.html. Accessed June 11, 2015.19

Mentions: The INTRABEAM PRS500 electronic Brachytherapy System (Carl Zeiss Surgical, Oberkochen, Germany) is a mobile X-ray source that was initially developed to treat intracranial lesions and can be used to treat a variety of malignant lesions (Figure 3).19 Like the Xoft Axxent, it can be used to treat skin, breast, and gynecological cancers, but also has a needle applicator that can be applied to treat spinal metastases.15,19 The system consists of an X-ray source, a control console, a user terminal, and attachments to verify accurate treatment. Treatment times are entered into the control console, and one of the four flat applicators for surface treatment is attached to the probe and used to deliver the dose. Treatment times range between 5 minutes and 30 minutes. Applicators for surface treatment are available in 10 mm, 20 mm, 30 mm, and 40 mm diameter and can be sterilized and reused (Figure 4).19 The miniature X-ray source, the XRS 4, measures 11 cm in length and has a 3.2 mm diameter probe. The SSD is variable between 9.6 mm and 21.6 mm based on the applicator size and the filter. Like the Axxent, the INTRABEAM produces maximum photon energies of 50 kV via the interaction of accelerated electrons with a gold target and requires minimal shielding. Beam current can be set between 5 μA and 40 μA, and photons are emitted in an isotropic pattern from the end of the probe. The source also contains a beam deflector and an internal radiation monitor that continuously monitors the treatment to measure the dose delivered. The INTRABEAM has a dose rate of ~2 Gy/min at 1 cm of water.17,19,20 The INTRABEAM PRS500 skin Electronic Brachytherapy System has been commercially available since 2013.


Novel treatment options for nonmelanoma skin cancer: focus on electronic brachytherapy.

Kasper ME, Chaudhary AA - Med Devices (Auckl) (2015)

A surface applicator used for electronic brachytherapy with the Zeiss® INTRABEAM® (Carl Zeiss Surgical) PRS500 System.Note: Reproduced from Zeiss.com [homepage on the Internet]. INTRABEAM: Precision and Ease of Use. Jena, Germany: Carl Zeiss Meditec AG, 2014. Available from: http://www.zeiss.com/meditec/en_us/products-solutions/intraoperative-radiotherapy/intrabeam-for-breast-cancer/intrabeam.html. Accessed June 11, 2015.19
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664532&req=5

f4-mder-8-493: A surface applicator used for electronic brachytherapy with the Zeiss® INTRABEAM® (Carl Zeiss Surgical) PRS500 System.Note: Reproduced from Zeiss.com [homepage on the Internet]. INTRABEAM: Precision and Ease of Use. Jena, Germany: Carl Zeiss Meditec AG, 2014. Available from: http://www.zeiss.com/meditec/en_us/products-solutions/intraoperative-radiotherapy/intrabeam-for-breast-cancer/intrabeam.html. Accessed June 11, 2015.19
Mentions: The INTRABEAM PRS500 electronic Brachytherapy System (Carl Zeiss Surgical, Oberkochen, Germany) is a mobile X-ray source that was initially developed to treat intracranial lesions and can be used to treat a variety of malignant lesions (Figure 3).19 Like the Xoft Axxent, it can be used to treat skin, breast, and gynecological cancers, but also has a needle applicator that can be applied to treat spinal metastases.15,19 The system consists of an X-ray source, a control console, a user terminal, and attachments to verify accurate treatment. Treatment times are entered into the control console, and one of the four flat applicators for surface treatment is attached to the probe and used to deliver the dose. Treatment times range between 5 minutes and 30 minutes. Applicators for surface treatment are available in 10 mm, 20 mm, 30 mm, and 40 mm diameter and can be sterilized and reused (Figure 4).19 The miniature X-ray source, the XRS 4, measures 11 cm in length and has a 3.2 mm diameter probe. The SSD is variable between 9.6 mm and 21.6 mm based on the applicator size and the filter. Like the Axxent, the INTRABEAM produces maximum photon energies of 50 kV via the interaction of accelerated electrons with a gold target and requires minimal shielding. Beam current can be set between 5 μA and 40 μA, and photons are emitted in an isotropic pattern from the end of the probe. The source also contains a beam deflector and an internal radiation monitor that continuously monitors the treatment to measure the dose delivered. The INTRABEAM has a dose rate of ~2 Gy/min at 1 cm of water.17,19,20 The INTRABEAM PRS500 skin Electronic Brachytherapy System has been commercially available since 2013.

Bottom Line: Radiotherapy has a long history in the treatment of NMSC.Shortly after the discovery of X-rays and (226)Radium, physicians cured patients with NMSC using these new treatments.Both X-ray therapy and brachytherapy have evolved over the years, ultimately delivering higher cure rates and lower toxicity.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Lynn Cancer Institute at Boca Raton Regional Hospital, Boca Raton, USA ; Charles E. Schmidt College of Medicine, Florida Atlantic University, FL, USA.

ABSTRACT
Nonmelanoma skin cancer (NMSC) is an increasing health care issue in the United States, significantly affecting quality of life and impacting health care costs. Radiotherapy has a long history in the treatment of NMSC. Shortly after the discovery of X-rays and (226)Radium, physicians cured patients with NMSC using these new treatments. Both X-ray therapy and brachytherapy have evolved over the years, ultimately delivering higher cure rates and lower toxicity. Electronic brachytherapy for NMSC is based on the technical and clinical data obtained from radionuclide skin surface brachytherapy and the small skin surface applicators developed over the past 25 years. The purpose of this review is to introduce electronic brachytherapy in the context of the history, data, and utilization of traditional radiotherapy and brachytherapy.

No MeSH data available.


Related in: MedlinePlus