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Expression of CPEB4 in invasive ductal breast carcinoma and its prognostic significance.

Sun HT, Wen X, Han T, Liu ZH, Li SB, Wang JG, Liu XP - Onco Targets Ther (2015)

Bottom Line: Patients with high expression of CPEB4 showed shorter overall survival (P=0.001).High CPEB4 expression was an independent prognostic factor for overall survival (P=0.022, hazard ratio =4.344, 95% confidence interval =1.235-15.283).High CPEB4 expression is associated with increased histological grading and N stage, and it can serve as an independent prognostic factor in IDC.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, People's Republic of China ; Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.

ABSTRACT

Aims: Cytoplasmic polyadenylation element binding proteins (CPEBs) are RNA-binding proteins that regulate translation by inducing cytoplasmic polyadenylation. CPEB4 has been reported in association with tumor growth, vascularization, and invasion in several cancers. To date, the expression of CPEB4 with clinical prognosis of breast cancer was never reported before. We aim to investigate the expression of CPEB4 and its prognostic significance in invasive ductal breast carcinoma.

Methods: Immunohistochemical staining of CPEB4 and estrogen receptor, progesterone receptor, and human epidermal growth factor receptor was performed in 107 invasive ductal carcinoma (IDC) samples, and prognostic significance was evaluated.

Results: High expression of CPEB4 was observed in 48.6% of IDC samples. Elevated CPEB4 expression was possibly related to increased histological grading (P=0.037) and N stage (P<0.001). Patients with high expression of CPEB4 showed shorter overall survival (P=0.001). High CPEB4 expression was an independent prognostic factor for overall survival (P=0.022, hazard ratio =4.344, 95% confidence interval =1.235-15.283).

Conclusion: High CPEB4 expression is associated with increased histological grading and N stage, and it can serve as an independent prognostic factor in IDC.

No MeSH data available.


Related in: MedlinePlus

Kaplan–Meier survival curves of overall survival of 107 IDC patients according to CPEB4 expression (A), HER2 expression (B), and TNM stage (C) were demonstrated.Abbreviations: IDC, invasive ductal carcinoma; CPEB4, cytoplasmic polyadenylation element binding protein 4; HER2, human epidermal growth factor receptor-2; TNM, tumor, node, metastasis.
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f3-ott-8-3499: Kaplan–Meier survival curves of overall survival of 107 IDC patients according to CPEB4 expression (A), HER2 expression (B), and TNM stage (C) were demonstrated.Abbreviations: IDC, invasive ductal carcinoma; CPEB4, cytoplasmic polyadenylation element binding protein 4; HER2, human epidermal growth factor receptor-2; TNM, tumor, node, metastasis.

Mentions: Correlation between higher CPEB4 expression and shorter overall survival times was revealed by Kaplan–Meier survival analysis (P=0.001, log-rank test) (Figure 3A). High HER2 expression and advanced TNM stage were both negatively correlated to survival time (P=0.020, P<0.001, log-rank test) (Figure 3B and C).


Expression of CPEB4 in invasive ductal breast carcinoma and its prognostic significance.

Sun HT, Wen X, Han T, Liu ZH, Li SB, Wang JG, Liu XP - Onco Targets Ther (2015)

Kaplan–Meier survival curves of overall survival of 107 IDC patients according to CPEB4 expression (A), HER2 expression (B), and TNM stage (C) were demonstrated.Abbreviations: IDC, invasive ductal carcinoma; CPEB4, cytoplasmic polyadenylation element binding protein 4; HER2, human epidermal growth factor receptor-2; TNM, tumor, node, metastasis.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664518&req=5

f3-ott-8-3499: Kaplan–Meier survival curves of overall survival of 107 IDC patients according to CPEB4 expression (A), HER2 expression (B), and TNM stage (C) were demonstrated.Abbreviations: IDC, invasive ductal carcinoma; CPEB4, cytoplasmic polyadenylation element binding protein 4; HER2, human epidermal growth factor receptor-2; TNM, tumor, node, metastasis.
Mentions: Correlation between higher CPEB4 expression and shorter overall survival times was revealed by Kaplan–Meier survival analysis (P=0.001, log-rank test) (Figure 3A). High HER2 expression and advanced TNM stage were both negatively correlated to survival time (P=0.020, P<0.001, log-rank test) (Figure 3B and C).

Bottom Line: Patients with high expression of CPEB4 showed shorter overall survival (P=0.001).High CPEB4 expression was an independent prognostic factor for overall survival (P=0.022, hazard ratio =4.344, 95% confidence interval =1.235-15.283).High CPEB4 expression is associated with increased histological grading and N stage, and it can serve as an independent prognostic factor in IDC.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, People's Republic of China ; Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.

ABSTRACT

Aims: Cytoplasmic polyadenylation element binding proteins (CPEBs) are RNA-binding proteins that regulate translation by inducing cytoplasmic polyadenylation. CPEB4 has been reported in association with tumor growth, vascularization, and invasion in several cancers. To date, the expression of CPEB4 with clinical prognosis of breast cancer was never reported before. We aim to investigate the expression of CPEB4 and its prognostic significance in invasive ductal breast carcinoma.

Methods: Immunohistochemical staining of CPEB4 and estrogen receptor, progesterone receptor, and human epidermal growth factor receptor was performed in 107 invasive ductal carcinoma (IDC) samples, and prognostic significance was evaluated.

Results: High expression of CPEB4 was observed in 48.6% of IDC samples. Elevated CPEB4 expression was possibly related to increased histological grading (P=0.037) and N stage (P<0.001). Patients with high expression of CPEB4 showed shorter overall survival (P=0.001). High CPEB4 expression was an independent prognostic factor for overall survival (P=0.022, hazard ratio =4.344, 95% confidence interval =1.235-15.283).

Conclusion: High CPEB4 expression is associated with increased histological grading and N stage, and it can serve as an independent prognostic factor in IDC.

No MeSH data available.


Related in: MedlinePlus