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Expression of CPEB4 in invasive ductal breast carcinoma and its prognostic significance.

Sun HT, Wen X, Han T, Liu ZH, Li SB, Wang JG, Liu XP - Onco Targets Ther (2015)

Bottom Line: Patients with high expression of CPEB4 showed shorter overall survival (P=0.001).High CPEB4 expression was an independent prognostic factor for overall survival (P=0.022, hazard ratio =4.344, 95% confidence interval =1.235-15.283).High CPEB4 expression is associated with increased histological grading and N stage, and it can serve as an independent prognostic factor in IDC.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, People's Republic of China ; Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.

ABSTRACT

Aims: Cytoplasmic polyadenylation element binding proteins (CPEBs) are RNA-binding proteins that regulate translation by inducing cytoplasmic polyadenylation. CPEB4 has been reported in association with tumor growth, vascularization, and invasion in several cancers. To date, the expression of CPEB4 with clinical prognosis of breast cancer was never reported before. We aim to investigate the expression of CPEB4 and its prognostic significance in invasive ductal breast carcinoma.

Methods: Immunohistochemical staining of CPEB4 and estrogen receptor, progesterone receptor, and human epidermal growth factor receptor was performed in 107 invasive ductal carcinoma (IDC) samples, and prognostic significance was evaluated.

Results: High expression of CPEB4 was observed in 48.6% of IDC samples. Elevated CPEB4 expression was possibly related to increased histological grading (P=0.037) and N stage (P<0.001). Patients with high expression of CPEB4 showed shorter overall survival (P=0.001). High CPEB4 expression was an independent prognostic factor for overall survival (P=0.022, hazard ratio =4.344, 95% confidence interval =1.235-15.283).

Conclusion: High CPEB4 expression is associated with increased histological grading and N stage, and it can serve as an independent prognostic factor in IDC.

No MeSH data available.


Related in: MedlinePlus

Representative photographs of ER, PR, and HER2 staining in IDC tissues.Notes: ER and PR are stained brown in the nucleus, while HER2 in the membrane. If <10% cells are stained or the staining is weak, the sample is regarded as negative. (A) Negative ER staining in IDC tissues. (B) Positive ER staining in IDC tissues. (C) Negative PR staining in IDC tissues. (D) Positive PR staining in IDC tissues. (E) Negative HER2 staining in IDC tissues. (F) Positive HER2 staining in IDC tissues.Abbreviations: ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor-2; IDC, invasive ductal carcinoma.
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f2-ott-8-3499: Representative photographs of ER, PR, and HER2 staining in IDC tissues.Notes: ER and PR are stained brown in the nucleus, while HER2 in the membrane. If <10% cells are stained or the staining is weak, the sample is regarded as negative. (A) Negative ER staining in IDC tissues. (B) Positive ER staining in IDC tissues. (C) Negative PR staining in IDC tissues. (D) Positive PR staining in IDC tissues. (E) Negative HER2 staining in IDC tissues. (F) Positive HER2 staining in IDC tissues.Abbreviations: ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor-2; IDC, invasive ductal carcinoma.

Mentions: For ER, PR, and HER2, typical patterns of positive and negative immunohistochemical staining are shown in Figure 2. ER and PR were stained brown in the nucleus, while HER2 in the membrane. Positive rates for ER, PR, and HER2 were 49.5%, 42.1%, and 64.5%, respectively, in our 107 IDCs.


Expression of CPEB4 in invasive ductal breast carcinoma and its prognostic significance.

Sun HT, Wen X, Han T, Liu ZH, Li SB, Wang JG, Liu XP - Onco Targets Ther (2015)

Representative photographs of ER, PR, and HER2 staining in IDC tissues.Notes: ER and PR are stained brown in the nucleus, while HER2 in the membrane. If <10% cells are stained or the staining is weak, the sample is regarded as negative. (A) Negative ER staining in IDC tissues. (B) Positive ER staining in IDC tissues. (C) Negative PR staining in IDC tissues. (D) Positive PR staining in IDC tissues. (E) Negative HER2 staining in IDC tissues. (F) Positive HER2 staining in IDC tissues.Abbreviations: ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor-2; IDC, invasive ductal carcinoma.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664518&req=5

f2-ott-8-3499: Representative photographs of ER, PR, and HER2 staining in IDC tissues.Notes: ER and PR are stained brown in the nucleus, while HER2 in the membrane. If <10% cells are stained or the staining is weak, the sample is regarded as negative. (A) Negative ER staining in IDC tissues. (B) Positive ER staining in IDC tissues. (C) Negative PR staining in IDC tissues. (D) Positive PR staining in IDC tissues. (E) Negative HER2 staining in IDC tissues. (F) Positive HER2 staining in IDC tissues.Abbreviations: ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor-2; IDC, invasive ductal carcinoma.
Mentions: For ER, PR, and HER2, typical patterns of positive and negative immunohistochemical staining are shown in Figure 2. ER and PR were stained brown in the nucleus, while HER2 in the membrane. Positive rates for ER, PR, and HER2 were 49.5%, 42.1%, and 64.5%, respectively, in our 107 IDCs.

Bottom Line: Patients with high expression of CPEB4 showed shorter overall survival (P=0.001).High CPEB4 expression was an independent prognostic factor for overall survival (P=0.022, hazard ratio =4.344, 95% confidence interval =1.235-15.283).High CPEB4 expression is associated with increased histological grading and N stage, and it can serve as an independent prognostic factor in IDC.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, People's Republic of China ; Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.

ABSTRACT

Aims: Cytoplasmic polyadenylation element binding proteins (CPEBs) are RNA-binding proteins that regulate translation by inducing cytoplasmic polyadenylation. CPEB4 has been reported in association with tumor growth, vascularization, and invasion in several cancers. To date, the expression of CPEB4 with clinical prognosis of breast cancer was never reported before. We aim to investigate the expression of CPEB4 and its prognostic significance in invasive ductal breast carcinoma.

Methods: Immunohistochemical staining of CPEB4 and estrogen receptor, progesterone receptor, and human epidermal growth factor receptor was performed in 107 invasive ductal carcinoma (IDC) samples, and prognostic significance was evaluated.

Results: High expression of CPEB4 was observed in 48.6% of IDC samples. Elevated CPEB4 expression was possibly related to increased histological grading (P=0.037) and N stage (P<0.001). Patients with high expression of CPEB4 showed shorter overall survival (P=0.001). High CPEB4 expression was an independent prognostic factor for overall survival (P=0.022, hazard ratio =4.344, 95% confidence interval =1.235-15.283).

Conclusion: High CPEB4 expression is associated with increased histological grading and N stage, and it can serve as an independent prognostic factor in IDC.

No MeSH data available.


Related in: MedlinePlus