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Expression of CPEB4 in invasive ductal breast carcinoma and its prognostic significance.

Sun HT, Wen X, Han T, Liu ZH, Li SB, Wang JG, Liu XP - Onco Targets Ther (2015)

Bottom Line: Patients with high expression of CPEB4 showed shorter overall survival (P=0.001).High CPEB4 expression was an independent prognostic factor for overall survival (P=0.022, hazard ratio =4.344, 95% confidence interval =1.235-15.283).High CPEB4 expression is associated with increased histological grading and N stage, and it can serve as an independent prognostic factor in IDC.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, People's Republic of China ; Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.

ABSTRACT

Aims: Cytoplasmic polyadenylation element binding proteins (CPEBs) are RNA-binding proteins that regulate translation by inducing cytoplasmic polyadenylation. CPEB4 has been reported in association with tumor growth, vascularization, and invasion in several cancers. To date, the expression of CPEB4 with clinical prognosis of breast cancer was never reported before. We aim to investigate the expression of CPEB4 and its prognostic significance in invasive ductal breast carcinoma.

Methods: Immunohistochemical staining of CPEB4 and estrogen receptor, progesterone receptor, and human epidermal growth factor receptor was performed in 107 invasive ductal carcinoma (IDC) samples, and prognostic significance was evaluated.

Results: High expression of CPEB4 was observed in 48.6% of IDC samples. Elevated CPEB4 expression was possibly related to increased histological grading (P=0.037) and N stage (P<0.001). Patients with high expression of CPEB4 showed shorter overall survival (P=0.001). High CPEB4 expression was an independent prognostic factor for overall survival (P=0.022, hazard ratio =4.344, 95% confidence interval =1.235-15.283).

Conclusion: High CPEB4 expression is associated with increased histological grading and N stage, and it can serve as an independent prognostic factor in IDC.

No MeSH data available.


Related in: MedlinePlus

Representative photographs of CPEB4 staining in normal and malignant breast tissues.Notes: (A) In normal breast tissues, CPEB4 was negative in all adipocytes and myoepithelial cells but sometimes positive in ductal epithelium. (B) In Grade I IDC, no staining of CPEB4 was observed. (C) Cytoplasm of Grade II IDC cells was stained weakly positive. (D) High expression in cytoplasm of Grade III IDC. (E) Quantification of CPEB4 expression in IDC tissue samples according to histology. The stacked bars show the percent contribution of high and low CPEB4-positive samples. All representative images are taken on power of ×400.Abbreviations: CPEB4, cytoplasmic polyadenylation element binding protein 4; IDC, invasive ductal carcinoma.
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f1-ott-8-3499: Representative photographs of CPEB4 staining in normal and malignant breast tissues.Notes: (A) In normal breast tissues, CPEB4 was negative in all adipocytes and myoepithelial cells but sometimes positive in ductal epithelium. (B) In Grade I IDC, no staining of CPEB4 was observed. (C) Cytoplasm of Grade II IDC cells was stained weakly positive. (D) High expression in cytoplasm of Grade III IDC. (E) Quantification of CPEB4 expression in IDC tissue samples according to histology. The stacked bars show the percent contribution of high and low CPEB4-positive samples. All representative images are taken on power of ×400.Abbreviations: CPEB4, cytoplasmic polyadenylation element binding protein 4; IDC, invasive ductal carcinoma.

Mentions: We analyzed CPEB4 expression in 107 primary IDC samples. Immunoreactivity of CPEB4 was detected only in cytoplasm. In normal breast tissues, CPEB4 was negative in all adipocytes and myoepithelial cells but sometimes positive in ductal epithelium (Figure 1). High expression of CPEB4 expression was observed in 48.6% (52/107) of IDC samples.


Expression of CPEB4 in invasive ductal breast carcinoma and its prognostic significance.

Sun HT, Wen X, Han T, Liu ZH, Li SB, Wang JG, Liu XP - Onco Targets Ther (2015)

Representative photographs of CPEB4 staining in normal and malignant breast tissues.Notes: (A) In normal breast tissues, CPEB4 was negative in all adipocytes and myoepithelial cells but sometimes positive in ductal epithelium. (B) In Grade I IDC, no staining of CPEB4 was observed. (C) Cytoplasm of Grade II IDC cells was stained weakly positive. (D) High expression in cytoplasm of Grade III IDC. (E) Quantification of CPEB4 expression in IDC tissue samples according to histology. The stacked bars show the percent contribution of high and low CPEB4-positive samples. All representative images are taken on power of ×400.Abbreviations: CPEB4, cytoplasmic polyadenylation element binding protein 4; IDC, invasive ductal carcinoma.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664518&req=5

f1-ott-8-3499: Representative photographs of CPEB4 staining in normal and malignant breast tissues.Notes: (A) In normal breast tissues, CPEB4 was negative in all adipocytes and myoepithelial cells but sometimes positive in ductal epithelium. (B) In Grade I IDC, no staining of CPEB4 was observed. (C) Cytoplasm of Grade II IDC cells was stained weakly positive. (D) High expression in cytoplasm of Grade III IDC. (E) Quantification of CPEB4 expression in IDC tissue samples according to histology. The stacked bars show the percent contribution of high and low CPEB4-positive samples. All representative images are taken on power of ×400.Abbreviations: CPEB4, cytoplasmic polyadenylation element binding protein 4; IDC, invasive ductal carcinoma.
Mentions: We analyzed CPEB4 expression in 107 primary IDC samples. Immunoreactivity of CPEB4 was detected only in cytoplasm. In normal breast tissues, CPEB4 was negative in all adipocytes and myoepithelial cells but sometimes positive in ductal epithelium (Figure 1). High expression of CPEB4 expression was observed in 48.6% (52/107) of IDC samples.

Bottom Line: Patients with high expression of CPEB4 showed shorter overall survival (P=0.001).High CPEB4 expression was an independent prognostic factor for overall survival (P=0.022, hazard ratio =4.344, 95% confidence interval =1.235-15.283).High CPEB4 expression is associated with increased histological grading and N stage, and it can serve as an independent prognostic factor in IDC.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, People's Republic of China ; Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.

ABSTRACT

Aims: Cytoplasmic polyadenylation element binding proteins (CPEBs) are RNA-binding proteins that regulate translation by inducing cytoplasmic polyadenylation. CPEB4 has been reported in association with tumor growth, vascularization, and invasion in several cancers. To date, the expression of CPEB4 with clinical prognosis of breast cancer was never reported before. We aim to investigate the expression of CPEB4 and its prognostic significance in invasive ductal breast carcinoma.

Methods: Immunohistochemical staining of CPEB4 and estrogen receptor, progesterone receptor, and human epidermal growth factor receptor was performed in 107 invasive ductal carcinoma (IDC) samples, and prognostic significance was evaluated.

Results: High expression of CPEB4 was observed in 48.6% of IDC samples. Elevated CPEB4 expression was possibly related to increased histological grading (P=0.037) and N stage (P<0.001). Patients with high expression of CPEB4 showed shorter overall survival (P=0.001). High CPEB4 expression was an independent prognostic factor for overall survival (P=0.022, hazard ratio =4.344, 95% confidence interval =1.235-15.283).

Conclusion: High CPEB4 expression is associated with increased histological grading and N stage, and it can serve as an independent prognostic factor in IDC.

No MeSH data available.


Related in: MedlinePlus