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Biomarkers of cancer angioprevention for clinical studies.

Albini A, Bertolini F, Bassani B, Bruno A, Gallo C, Caraffi SG, Maramotti S, Noonan DM - Ecancermedicalscience (2015)

Bottom Line: Prevention approaches range from avoiding tobacco exposure to dietary strategies to active pharmacological approaches in higher risk groups.Angioprevention i.e. preventing cancer angiogenesis is a key concept that we introduced; yet one of the major current challenges for anti-angiogenesis in therapy and prevention is finding the right biomarkers.Here we discuss the importance of angioprevention and the potential use of VEGF, PlGF, CD31, Ang and Tie, circulating vascular cell precursors, and microRNA as potential biomarkers.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Translational Oncology, Department of Research and Statistics, IRCCS Arcispedale Santa Maria Nuova, Reggio Emilia 42123, Italy ; These authors share equal contribution.

ABSTRACT
With the great advances made in the treatment and prevention of infectious diseases over the last century, chronic degenerative diseases-cardiovascular, cerebrovascular, and cancer-represent the major causes of death in the developed world. Although massive efforts and investments have been made in cancer therapy, the progress made towards reducing mortality has been more successful for cardiovascular disease than for tumours. This can be attributable largely to an active prevention approach implemented for cardiovascular disease. Cardiologists treat their patients before the overt disease becomes life threatening, performing early interventions in phenotypically healthy patients, by using several markers that predict risk. If the concept of prevention could be applied to cancer in a more extensive way, a significant number of tumours could be avoided through preventive measures. Prevention approaches range from avoiding tobacco exposure to dietary strategies to active pharmacological approaches in higher risk groups. Host targets rather than the tumour cells themselves are attractive for chemoprevention, in particular endothelial and immune cells. Angioprevention i.e. preventing cancer angiogenesis is a key concept that we introduced; yet one of the major current challenges for anti-angiogenesis in therapy and prevention is finding the right biomarkers. Here we discuss the importance of angioprevention and the potential use of VEGF, PlGF, CD31, Ang and Tie, circulating vascular cell precursors, and microRNA as potential biomarkers.

No MeSH data available.


Related in: MedlinePlus

Phytochemicals inhibit the NF-κB pathway. Chemopreventive compounds are able to suppress NF-κB activity by inhibiting its nuclear translocation. NF-κB is normally associated with its inhibitor IκB. The activation of IKK leads to IκB phosphorylation and subsequent degradation by the proteasome. Thus, NF-κB is released and translocates to the nucleus, where it is able to bind consensus sequences that lead to the transcription of pro-survival, inflammatory, and angiogenic molecules. Widely used phytochemicals are able to interfere with NF-κB activation, mostly by targeting IKK activity and decreasing the phosphorylation of IκB.
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figure1: Phytochemicals inhibit the NF-κB pathway. Chemopreventive compounds are able to suppress NF-κB activity by inhibiting its nuclear translocation. NF-κB is normally associated with its inhibitor IκB. The activation of IKK leads to IκB phosphorylation and subsequent degradation by the proteasome. Thus, NF-κB is released and translocates to the nucleus, where it is able to bind consensus sequences that lead to the transcription of pro-survival, inflammatory, and angiogenic molecules. Widely used phytochemicals are able to interfere with NF-κB activation, mostly by targeting IKK activity and decreasing the phosphorylation of IκB.

Mentions: A common pathway targeted by many phytochemicals is the NF-kB pathway [10, 13], a master regulator of both inflammation and angiogenesis (Figure 1). Another pathway targeted by some phytochemicals involves serine/threonine kinase Akt signalling, which is intertwined with the NF-kB pathway.


Biomarkers of cancer angioprevention for clinical studies.

Albini A, Bertolini F, Bassani B, Bruno A, Gallo C, Caraffi SG, Maramotti S, Noonan DM - Ecancermedicalscience (2015)

Phytochemicals inhibit the NF-κB pathway. Chemopreventive compounds are able to suppress NF-κB activity by inhibiting its nuclear translocation. NF-κB is normally associated with its inhibitor IκB. The activation of IKK leads to IκB phosphorylation and subsequent degradation by the proteasome. Thus, NF-κB is released and translocates to the nucleus, where it is able to bind consensus sequences that lead to the transcription of pro-survival, inflammatory, and angiogenic molecules. Widely used phytochemicals are able to interfere with NF-κB activation, mostly by targeting IKK activity and decreasing the phosphorylation of IκB.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664506&req=5

figure1: Phytochemicals inhibit the NF-κB pathway. Chemopreventive compounds are able to suppress NF-κB activity by inhibiting its nuclear translocation. NF-κB is normally associated with its inhibitor IκB. The activation of IKK leads to IκB phosphorylation and subsequent degradation by the proteasome. Thus, NF-κB is released and translocates to the nucleus, where it is able to bind consensus sequences that lead to the transcription of pro-survival, inflammatory, and angiogenic molecules. Widely used phytochemicals are able to interfere with NF-κB activation, mostly by targeting IKK activity and decreasing the phosphorylation of IκB.
Mentions: A common pathway targeted by many phytochemicals is the NF-kB pathway [10, 13], a master regulator of both inflammation and angiogenesis (Figure 1). Another pathway targeted by some phytochemicals involves serine/threonine kinase Akt signalling, which is intertwined with the NF-kB pathway.

Bottom Line: Prevention approaches range from avoiding tobacco exposure to dietary strategies to active pharmacological approaches in higher risk groups.Angioprevention i.e. preventing cancer angiogenesis is a key concept that we introduced; yet one of the major current challenges for anti-angiogenesis in therapy and prevention is finding the right biomarkers.Here we discuss the importance of angioprevention and the potential use of VEGF, PlGF, CD31, Ang and Tie, circulating vascular cell precursors, and microRNA as potential biomarkers.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Translational Oncology, Department of Research and Statistics, IRCCS Arcispedale Santa Maria Nuova, Reggio Emilia 42123, Italy ; These authors share equal contribution.

ABSTRACT
With the great advances made in the treatment and prevention of infectious diseases over the last century, chronic degenerative diseases-cardiovascular, cerebrovascular, and cancer-represent the major causes of death in the developed world. Although massive efforts and investments have been made in cancer therapy, the progress made towards reducing mortality has been more successful for cardiovascular disease than for tumours. This can be attributable largely to an active prevention approach implemented for cardiovascular disease. Cardiologists treat their patients before the overt disease becomes life threatening, performing early interventions in phenotypically healthy patients, by using several markers that predict risk. If the concept of prevention could be applied to cancer in a more extensive way, a significant number of tumours could be avoided through preventive measures. Prevention approaches range from avoiding tobacco exposure to dietary strategies to active pharmacological approaches in higher risk groups. Host targets rather than the tumour cells themselves are attractive for chemoprevention, in particular endothelial and immune cells. Angioprevention i.e. preventing cancer angiogenesis is a key concept that we introduced; yet one of the major current challenges for anti-angiogenesis in therapy and prevention is finding the right biomarkers. Here we discuss the importance of angioprevention and the potential use of VEGF, PlGF, CD31, Ang and Tie, circulating vascular cell precursors, and microRNA as potential biomarkers.

No MeSH data available.


Related in: MedlinePlus