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Trihydroxybenzoic acid glucoside as a global skin color modulator and photo-protectant.

Chajra H, Redziniak G, Auriol D, Schweikert K, Lefevre F - Clin Cosmet Investig Dermatol (2015)

Bottom Line: We have demonstrated using histological staining that THBG decrease epidermis melanin content under unirradiated and irradiated condition.We also confirmed that THBG molecule is not a sunscreen agent.This study demonstrated that THBG controls skin tone via the inhibition of melanin synthesis as well as the modulation of skin brightness, yellowness, and redness.

View Article: PubMed Central - PubMed

Affiliation: Induchem AG, Volkestwil, Switzerland.

ABSTRACT

Background: 3,4,5-Trihydroxybenzoic acid glucoside (THBG), a molecule produced by an original biocatalysis-based technology, was assessed in this study with respect to its skin photoprotective capacity and its skin color control property on Asian-type skin at a clinical level and on skin explant culture models.

Methods: The double-blinded clinical study was done in comparison to a vehicle by the determination of objective color parameters thanks to recognized quantitative and qualitative analysis tools, including Chroma-Meter, VISIA-CR™, and SIAscope™. Determination of L* (brightness), a* and b* (green-red and blue-yellow chromaticity coordinates), individual typology angle, and C* (chroma) and h* (hue angle) parameters using a Chroma-Meter demonstrated that THBG is able to modify skin color while quantification of ultraviolet (UV) spots by VISIA-CR™ confirmed its photoprotective effect. The mechanism of action of THBG molecule was determined using explant skin culture model coupled to histological analysis (epidermis melanin content staining).

Results: We have demonstrated that THBG was able to modulate significantly several critical parameters involved in skin color control such as L* (brightness), a* (redness), individual typology angle (pigmentation), and hue angle (yellowness in this study), whereas no modification occurs on b* and C* parameters. We have demonstrated using histological staining that THBG decrease epidermis melanin content under unirradiated and irradiated condition. We also confirmed that THBG molecule is not a sunscreen agent.

Conclusion: This study demonstrated that THBG controls skin tone via the inhibition of melanin synthesis as well as the modulation of skin brightness, yellowness, and redness.

No MeSH data available.


Related in: MedlinePlus

Visualization of melanin content in skin explants cultured in presence or not of THBG at 2% and kojic acid at 1% (histological analysis, Fontana Masson staining).Abbreviations: THBG, 3,4,5-trihydroxybenzoic acid glucoside; D, day.
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f5-ccid-8-579: Visualization of melanin content in skin explants cultured in presence or not of THBG at 2% and kojic acid at 1% (histological analysis, Fontana Masson staining).Abbreviations: THBG, 3,4,5-trihydroxybenzoic acid glucoside; D, day.

Mentions: Kojic acid topically applied on skin explants showed a decrease in epidermis melanin content (Figure 5); this effect was not surprising as kojic acid is a known whitening agent. As expected, UV irradiation applied on skin stimulates melanin synthesis. This result validates the study model (Figure 6). THBG cream induced a strong and visible decrease of epidermis melanin content under unirradiated (Figure 5) and irradiated conditions (Figure 6).


Trihydroxybenzoic acid glucoside as a global skin color modulator and photo-protectant.

Chajra H, Redziniak G, Auriol D, Schweikert K, Lefevre F - Clin Cosmet Investig Dermatol (2015)

Visualization of melanin content in skin explants cultured in presence or not of THBG at 2% and kojic acid at 1% (histological analysis, Fontana Masson staining).Abbreviations: THBG, 3,4,5-trihydroxybenzoic acid glucoside; D, day.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664441&req=5

f5-ccid-8-579: Visualization of melanin content in skin explants cultured in presence or not of THBG at 2% and kojic acid at 1% (histological analysis, Fontana Masson staining).Abbreviations: THBG, 3,4,5-trihydroxybenzoic acid glucoside; D, day.
Mentions: Kojic acid topically applied on skin explants showed a decrease in epidermis melanin content (Figure 5); this effect was not surprising as kojic acid is a known whitening agent. As expected, UV irradiation applied on skin stimulates melanin synthesis. This result validates the study model (Figure 6). THBG cream induced a strong and visible decrease of epidermis melanin content under unirradiated (Figure 5) and irradiated conditions (Figure 6).

Bottom Line: We have demonstrated using histological staining that THBG decrease epidermis melanin content under unirradiated and irradiated condition.We also confirmed that THBG molecule is not a sunscreen agent.This study demonstrated that THBG controls skin tone via the inhibition of melanin synthesis as well as the modulation of skin brightness, yellowness, and redness.

View Article: PubMed Central - PubMed

Affiliation: Induchem AG, Volkestwil, Switzerland.

ABSTRACT

Background: 3,4,5-Trihydroxybenzoic acid glucoside (THBG), a molecule produced by an original biocatalysis-based technology, was assessed in this study with respect to its skin photoprotective capacity and its skin color control property on Asian-type skin at a clinical level and on skin explant culture models.

Methods: The double-blinded clinical study was done in comparison to a vehicle by the determination of objective color parameters thanks to recognized quantitative and qualitative analysis tools, including Chroma-Meter, VISIA-CR™, and SIAscope™. Determination of L* (brightness), a* and b* (green-red and blue-yellow chromaticity coordinates), individual typology angle, and C* (chroma) and h* (hue angle) parameters using a Chroma-Meter demonstrated that THBG is able to modify skin color while quantification of ultraviolet (UV) spots by VISIA-CR™ confirmed its photoprotective effect. The mechanism of action of THBG molecule was determined using explant skin culture model coupled to histological analysis (epidermis melanin content staining).

Results: We have demonstrated that THBG was able to modulate significantly several critical parameters involved in skin color control such as L* (brightness), a* (redness), individual typology angle (pigmentation), and hue angle (yellowness in this study), whereas no modification occurs on b* and C* parameters. We have demonstrated using histological staining that THBG decrease epidermis melanin content under unirradiated and irradiated condition. We also confirmed that THBG molecule is not a sunscreen agent.

Conclusion: This study demonstrated that THBG controls skin tone via the inhibition of melanin synthesis as well as the modulation of skin brightness, yellowness, and redness.

No MeSH data available.


Related in: MedlinePlus