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Trihydroxybenzoic acid glucoside as a global skin color modulator and photo-protectant.

Chajra H, Redziniak G, Auriol D, Schweikert K, Lefevre F - Clin Cosmet Investig Dermatol (2015)

Bottom Line: We have demonstrated using histological staining that THBG decrease epidermis melanin content under unirradiated and irradiated condition.We also confirmed that THBG molecule is not a sunscreen agent.This study demonstrated that THBG controls skin tone via the inhibition of melanin synthesis as well as the modulation of skin brightness, yellowness, and redness.

View Article: PubMed Central - PubMed

Affiliation: Induchem AG, Volkestwil, Switzerland.

ABSTRACT

Background: 3,4,5-Trihydroxybenzoic acid glucoside (THBG), a molecule produced by an original biocatalysis-based technology, was assessed in this study with respect to its skin photoprotective capacity and its skin color control property on Asian-type skin at a clinical level and on skin explant culture models.

Methods: The double-blinded clinical study was done in comparison to a vehicle by the determination of objective color parameters thanks to recognized quantitative and qualitative analysis tools, including Chroma-Meter, VISIA-CR™, and SIAscope™. Determination of L* (brightness), a* and b* (green-red and blue-yellow chromaticity coordinates), individual typology angle, and C* (chroma) and h* (hue angle) parameters using a Chroma-Meter demonstrated that THBG is able to modify skin color while quantification of ultraviolet (UV) spots by VISIA-CR™ confirmed its photoprotective effect. The mechanism of action of THBG molecule was determined using explant skin culture model coupled to histological analysis (epidermis melanin content staining).

Results: We have demonstrated that THBG was able to modulate significantly several critical parameters involved in skin color control such as L* (brightness), a* (redness), individual typology angle (pigmentation), and hue angle (yellowness in this study), whereas no modification occurs on b* and C* parameters. We have demonstrated using histological staining that THBG decrease epidermis melanin content under unirradiated and irradiated condition. We also confirmed that THBG molecule is not a sunscreen agent.

Conclusion: This study demonstrated that THBG controls skin tone via the inhibition of melanin synthesis as well as the modulation of skin brightness, yellowness, and redness.

No MeSH data available.


Related in: MedlinePlus

Melanin content visualization at D0 and after 14, 28, 56, and 84 days of placebo and THBG treatments (SIAscope™ tool, selection of two volunteers).Notes: Melanin content is not decreased or slightly decreased in vehicle cream treated side in comparison to THBG treatment where a clear decrease of melanin content is seen in spot area (represented by the dark spot “black color”) and normal area (represented by “gray color”).Abbreviations: THBG, 3,4,5-trihydroxybenzoic acid glucoside; n°, number; D, day.
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f1-ccid-8-579: Melanin content visualization at D0 and after 14, 28, 56, and 84 days of placebo and THBG treatments (SIAscope™ tool, selection of two volunteers).Notes: Melanin content is not decreased or slightly decreased in vehicle cream treated side in comparison to THBG treatment where a clear decrease of melanin content is seen in spot area (represented by the dark spot “black color”) and normal area (represented by “gray color”).Abbreviations: THBG, 3,4,5-trihydroxybenzoic acid glucoside; n°, number; D, day.

Mentions: Figure 1 illustrates melanin content pictures obtained from SIAscope™ equipment.


Trihydroxybenzoic acid glucoside as a global skin color modulator and photo-protectant.

Chajra H, Redziniak G, Auriol D, Schweikert K, Lefevre F - Clin Cosmet Investig Dermatol (2015)

Melanin content visualization at D0 and after 14, 28, 56, and 84 days of placebo and THBG treatments (SIAscope™ tool, selection of two volunteers).Notes: Melanin content is not decreased or slightly decreased in vehicle cream treated side in comparison to THBG treatment where a clear decrease of melanin content is seen in spot area (represented by the dark spot “black color”) and normal area (represented by “gray color”).Abbreviations: THBG, 3,4,5-trihydroxybenzoic acid glucoside; n°, number; D, day.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664441&req=5

f1-ccid-8-579: Melanin content visualization at D0 and after 14, 28, 56, and 84 days of placebo and THBG treatments (SIAscope™ tool, selection of two volunteers).Notes: Melanin content is not decreased or slightly decreased in vehicle cream treated side in comparison to THBG treatment where a clear decrease of melanin content is seen in spot area (represented by the dark spot “black color”) and normal area (represented by “gray color”).Abbreviations: THBG, 3,4,5-trihydroxybenzoic acid glucoside; n°, number; D, day.
Mentions: Figure 1 illustrates melanin content pictures obtained from SIAscope™ equipment.

Bottom Line: We have demonstrated using histological staining that THBG decrease epidermis melanin content under unirradiated and irradiated condition.We also confirmed that THBG molecule is not a sunscreen agent.This study demonstrated that THBG controls skin tone via the inhibition of melanin synthesis as well as the modulation of skin brightness, yellowness, and redness.

View Article: PubMed Central - PubMed

Affiliation: Induchem AG, Volkestwil, Switzerland.

ABSTRACT

Background: 3,4,5-Trihydroxybenzoic acid glucoside (THBG), a molecule produced by an original biocatalysis-based technology, was assessed in this study with respect to its skin photoprotective capacity and its skin color control property on Asian-type skin at a clinical level and on skin explant culture models.

Methods: The double-blinded clinical study was done in comparison to a vehicle by the determination of objective color parameters thanks to recognized quantitative and qualitative analysis tools, including Chroma-Meter, VISIA-CR™, and SIAscope™. Determination of L* (brightness), a* and b* (green-red and blue-yellow chromaticity coordinates), individual typology angle, and C* (chroma) and h* (hue angle) parameters using a Chroma-Meter demonstrated that THBG is able to modify skin color while quantification of ultraviolet (UV) spots by VISIA-CR™ confirmed its photoprotective effect. The mechanism of action of THBG molecule was determined using explant skin culture model coupled to histological analysis (epidermis melanin content staining).

Results: We have demonstrated that THBG was able to modulate significantly several critical parameters involved in skin color control such as L* (brightness), a* (redness), individual typology angle (pigmentation), and hue angle (yellowness in this study), whereas no modification occurs on b* and C* parameters. We have demonstrated using histological staining that THBG decrease epidermis melanin content under unirradiated and irradiated condition. We also confirmed that THBG molecule is not a sunscreen agent.

Conclusion: This study demonstrated that THBG controls skin tone via the inhibition of melanin synthesis as well as the modulation of skin brightness, yellowness, and redness.

No MeSH data available.


Related in: MedlinePlus