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Comparison of exercise capacity in COPD and other etiologies of chronic respiratory failure requiring non-invasive mechanical ventilation at home: retrospective analysis of 1-year follow-up.

Salturk C, Karakurt Z, Takir HB, Balci M, Kargin F, Mocin OY, Gungor G, Ozmen I, Oztas S, Yalcinsoy M, Evin R, Ozturk M, Adiguzel N - Int J Chron Obstruct Pulmon Dis (2015)

Bottom Line: The results of arterial blood gas (ABG) analyses and spirometry, and 6MWD measurements with 12-month interval were recorded from the patient files, in addition to demographics, comorbidities, and body mass indices.The groups were compared in terms of 6MWD via analysis of variance (ANOVA) and multiple linear regression (MLR) analysis (independent variables: analysis age, sex, baseline 6MWD, baseline forced expiratory volume in 1 second, and baseline partial carbon dioxide pressure, in reference to COPD group).Both univariate ANOVA and MLR showed that the OHS group had the lowest baseline 6MWD and the highest decrease in 1 year (linear regression coefficient -24.48; 95% CI -48.74 to -0.21, P=0.048); while the KS group had the best baseline values and the biggest improvement under home NIMV (linear regression coefficient 26.94; 95% CI -3.79 to 57.66, P=0.085).

View Article: PubMed Central - PubMed

Affiliation: Respiratory Intensive Care Unit, Sureyyapasa Chest Diseases and Thoracic Surgery Teaching and Research Hospital, Istanbul, Turkey.

ABSTRACT

Introduction: The objective of this study was to compare the change in 6-minute walking distance (6MWD) in 1 year as an indicator of exercise capacity among patients undergoing home non-invasive mechanical ventilation (NIMV) due to chronic hypercapnic respiratory failure (CHRF) caused by different etiologies.

Methods: This retrospective cohort study was conducted in a tertiary pulmonary disease hospital in patients who had completed 1-year follow-up under home NIMV because of CHRF with different etiologies (ie, chronic obstructive pulmonary disease [COPD], obesity hypoventilation syndrome [OHS], kyphoscoliosis [KS], and diffuse parenchymal lung disease [DPLD]), between January 2011 and January 2012. The results of arterial blood gas (ABG) analyses and spirometry, and 6MWD measurements with 12-month interval were recorded from the patient files, in addition to demographics, comorbidities, and body mass indices. The groups were compared in terms of 6MWD via analysis of variance (ANOVA) and multiple linear regression (MLR) analysis (independent variables: analysis age, sex, baseline 6MWD, baseline forced expiratory volume in 1 second, and baseline partial carbon dioxide pressure, in reference to COPD group).

Results: A total of 105 patients with a mean age (± standard deviation) of 61±12 years of whom 37 had COPD, 34 had OHS, 20 had KS, and 14 had DPLD were included in statistical analysis. There were no significant differences between groups in the baseline and delta values of ABG and spirometry findings. Both univariate ANOVA and MLR showed that the OHS group had the lowest baseline 6MWD and the highest decrease in 1 year (linear regression coefficient -24.48; 95% CI -48.74 to -0.21, P=0.048); while the KS group had the best baseline values and the biggest improvement under home NIMV (linear regression coefficient 26.94; 95% CI -3.79 to 57.66, P=0.085).

Conclusion: The 6MWD measurements revealed improvement in exercise capacity test in CHRF patients receiving home NIMV treatment on long-term depends on etiological diagnoses.

No MeSH data available.


Related in: MedlinePlus

Consort diagram showing patient enrollment, follow-up and analysis.Abbreviations: ABG, arterial blood gas analysis; COPD, chronic obstructive pulmonary disease; DPLD, diffuse parenchymal lung disease; ICU, intensive care unit; KS, kyphoscoliosis; NIMV, non-invasive mechanical ventilation; OHS, obesity hypoventilation syndrome; 6MWT, 6-minute walking test; SPASA, Sureyyapasa Chest Disease And Thoracic Surgery Teaching And Research Hospital.
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f1-copd-10-2559: Consort diagram showing patient enrollment, follow-up and analysis.Abbreviations: ABG, arterial blood gas analysis; COPD, chronic obstructive pulmonary disease; DPLD, diffuse parenchymal lung disease; ICU, intensive care unit; KS, kyphoscoliosis; NIMV, non-invasive mechanical ventilation; OHS, obesity hypoventilation syndrome; 6MWT, 6-minute walking test; SPASA, Sureyyapasa Chest Disease And Thoracic Surgery Teaching And Research Hospital.

Mentions: A total of 105 consecutive patients with CHRF who received NIMV treatment during their intensive care unit (ICU) hospitalization, and home NIMV post-discharge, were included in this retrospective study conducted from January 2011 to January 2012. Patients who received NIMV in the ICU, or at home for at least 4 hours per day, including nocturnal NIMV, and who attended the first follow-up visit 1 month after discharge and who completed a 1-year post-discharge follow-up at the respiratory intensive care outpatient clinic, were included in the study. These patients had not received NIMV prior to their ICU stay. Patients who were disabled or unwilling to walk, as well as patients with clinical signs of airway infection, current exacerbations, or unstable cardiac arrhythmia, were excluded. A consort diagram showing patient enrollment and study flow is presented in Figure 1.


Comparison of exercise capacity in COPD and other etiologies of chronic respiratory failure requiring non-invasive mechanical ventilation at home: retrospective analysis of 1-year follow-up.

Salturk C, Karakurt Z, Takir HB, Balci M, Kargin F, Mocin OY, Gungor G, Ozmen I, Oztas S, Yalcinsoy M, Evin R, Ozturk M, Adiguzel N - Int J Chron Obstruct Pulmon Dis (2015)

Consort diagram showing patient enrollment, follow-up and analysis.Abbreviations: ABG, arterial blood gas analysis; COPD, chronic obstructive pulmonary disease; DPLD, diffuse parenchymal lung disease; ICU, intensive care unit; KS, kyphoscoliosis; NIMV, non-invasive mechanical ventilation; OHS, obesity hypoventilation syndrome; 6MWT, 6-minute walking test; SPASA, Sureyyapasa Chest Disease And Thoracic Surgery Teaching And Research Hospital.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664429&req=5

f1-copd-10-2559: Consort diagram showing patient enrollment, follow-up and analysis.Abbreviations: ABG, arterial blood gas analysis; COPD, chronic obstructive pulmonary disease; DPLD, diffuse parenchymal lung disease; ICU, intensive care unit; KS, kyphoscoliosis; NIMV, non-invasive mechanical ventilation; OHS, obesity hypoventilation syndrome; 6MWT, 6-minute walking test; SPASA, Sureyyapasa Chest Disease And Thoracic Surgery Teaching And Research Hospital.
Mentions: A total of 105 consecutive patients with CHRF who received NIMV treatment during their intensive care unit (ICU) hospitalization, and home NIMV post-discharge, were included in this retrospective study conducted from January 2011 to January 2012. Patients who received NIMV in the ICU, or at home for at least 4 hours per day, including nocturnal NIMV, and who attended the first follow-up visit 1 month after discharge and who completed a 1-year post-discharge follow-up at the respiratory intensive care outpatient clinic, were included in the study. These patients had not received NIMV prior to their ICU stay. Patients who were disabled or unwilling to walk, as well as patients with clinical signs of airway infection, current exacerbations, or unstable cardiac arrhythmia, were excluded. A consort diagram showing patient enrollment and study flow is presented in Figure 1.

Bottom Line: The results of arterial blood gas (ABG) analyses and spirometry, and 6MWD measurements with 12-month interval were recorded from the patient files, in addition to demographics, comorbidities, and body mass indices.The groups were compared in terms of 6MWD via analysis of variance (ANOVA) and multiple linear regression (MLR) analysis (independent variables: analysis age, sex, baseline 6MWD, baseline forced expiratory volume in 1 second, and baseline partial carbon dioxide pressure, in reference to COPD group).Both univariate ANOVA and MLR showed that the OHS group had the lowest baseline 6MWD and the highest decrease in 1 year (linear regression coefficient -24.48; 95% CI -48.74 to -0.21, P=0.048); while the KS group had the best baseline values and the biggest improvement under home NIMV (linear regression coefficient 26.94; 95% CI -3.79 to 57.66, P=0.085).

View Article: PubMed Central - PubMed

Affiliation: Respiratory Intensive Care Unit, Sureyyapasa Chest Diseases and Thoracic Surgery Teaching and Research Hospital, Istanbul, Turkey.

ABSTRACT

Introduction: The objective of this study was to compare the change in 6-minute walking distance (6MWD) in 1 year as an indicator of exercise capacity among patients undergoing home non-invasive mechanical ventilation (NIMV) due to chronic hypercapnic respiratory failure (CHRF) caused by different etiologies.

Methods: This retrospective cohort study was conducted in a tertiary pulmonary disease hospital in patients who had completed 1-year follow-up under home NIMV because of CHRF with different etiologies (ie, chronic obstructive pulmonary disease [COPD], obesity hypoventilation syndrome [OHS], kyphoscoliosis [KS], and diffuse parenchymal lung disease [DPLD]), between January 2011 and January 2012. The results of arterial blood gas (ABG) analyses and spirometry, and 6MWD measurements with 12-month interval were recorded from the patient files, in addition to demographics, comorbidities, and body mass indices. The groups were compared in terms of 6MWD via analysis of variance (ANOVA) and multiple linear regression (MLR) analysis (independent variables: analysis age, sex, baseline 6MWD, baseline forced expiratory volume in 1 second, and baseline partial carbon dioxide pressure, in reference to COPD group).

Results: A total of 105 patients with a mean age (± standard deviation) of 61±12 years of whom 37 had COPD, 34 had OHS, 20 had KS, and 14 had DPLD were included in statistical analysis. There were no significant differences between groups in the baseline and delta values of ABG and spirometry findings. Both univariate ANOVA and MLR showed that the OHS group had the lowest baseline 6MWD and the highest decrease in 1 year (linear regression coefficient -24.48; 95% CI -48.74 to -0.21, P=0.048); while the KS group had the best baseline values and the biggest improvement under home NIMV (linear regression coefficient 26.94; 95% CI -3.79 to 57.66, P=0.085).

Conclusion: The 6MWD measurements revealed improvement in exercise capacity test in CHRF patients receiving home NIMV treatment on long-term depends on etiological diagnoses.

No MeSH data available.


Related in: MedlinePlus