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Competition and Cooperation among Relational Memory Representations.

Schwarb H, Watson PD, Campbell K, Shander CL, Monti JM, Cooke GE, Wang JX, Kramer AF, Cohen NJ - PLoS ONE (2015)

Bottom Line: In this task, participants learned unique face-room associations in two distinct contexts (i.e., different colored buildings).Overall, performance was very accurate.This novel task provides a powerful tool for investigating both the unique and interacting contributions of these systems in support of relational memory.

View Article: PubMed Central - PubMed

Affiliation: University of Illinois, Beckman Institute for Advanced Science and Technology, Urbana, IL, United States of America.

ABSTRACT
Mnemonic processing engages multiple systems that cooperate and compete to support task performance. Exploring these systems' interaction requires memory tasks that produce rich data with multiple patterns of performance sensitive to different processing sub-components. Here we present a novel context-dependent relational memory paradigm designed to engage multiple learning and memory systems. In this task, participants learned unique face-room associations in two distinct contexts (i.e., different colored buildings). Faces occupied rooms as determined by an implicit gender-by-side rule structure (e.g., male faces on the left and female faces on the right) and all faces were seen in both contexts. In two experiments, we use behavioral and eye-tracking measures to investigate interactions among different memory representations in both younger and older adult populations; furthermore we link these representations to volumetric variations in hippocampus and ventromedial PFC among older adults. Overall, performance was very accurate. Successful face placement into a studied room systematically varied with hippocampal volume. Selecting the studied room in the wrong context was the most typical error. The proportion of these errors to correct responses positively correlated with ventromedial prefrontal volume. This novel task provides a powerful tool for investigating both the unique and interacting contributions of these systems in support of relational memory.

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Related in: MedlinePlus

Behavior and volumetric relationships.(a) The correlation between bilateral hippocampal volume and preference for placing the face in the studied room as a proportion of all face placements to context-correct (green) and context-incorrect (blue) sides of the building. (b) The correlation between bilateral ventromedial prefrontal cortex volume and both correct novel face placements (purple) and Triad Scores (studied room placements on the context-incorrect side of the building divided by studied room placements to the context-correct side of the building; teal). All behavioral data were z-scored for presentation purposes.
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pone.0143832.g009: Behavior and volumetric relationships.(a) The correlation between bilateral hippocampal volume and preference for placing the face in the studied room as a proportion of all face placements to context-correct (green) and context-incorrect (blue) sides of the building. (b) The correlation between bilateral ventromedial prefrontal cortex volume and both correct novel face placements (purple) and Triad Scores (studied room placements on the context-incorrect side of the building divided by studied room placements to the context-correct side of the building; teal). All behavioral data were z-scored for presentation purposes.

Mentions: Volumetric data were also acquired from cortical and subcortical brain structures for older adult participants. Given the vast literature summarizing hippocampal involvement in binding arbitrary relations among stimuli in a host of relational memory tasks (e.g., [27–34]), the relationship between hippocampal volume (controlling for cranial volume) and memory performance on this novel task was investigated. Controlling for age, hippocampal volume positively correlated with the proportion of responses to studied rooms (CC-studied and CI-studied combined), r = .56, p = .013. Bilateral hippocampal volume also positively correlated with the proportion of CC-studied rooms over all other rooms on the CC side of the building, r = .59, p = .008 (Fig 9a). There was a non-significant trend for the relationship between bilateral hippocampal volume and the proportion of CI-studied rooms over all other rooms on the CI side of the building, r = .42, p = .075 (Fig 9a). Taken together, these data demonstrate that older adults with larger hippocampi were better at selecting a studied room than those with smaller hippocampi.


Competition and Cooperation among Relational Memory Representations.

Schwarb H, Watson PD, Campbell K, Shander CL, Monti JM, Cooke GE, Wang JX, Kramer AF, Cohen NJ - PLoS ONE (2015)

Behavior and volumetric relationships.(a) The correlation between bilateral hippocampal volume and preference for placing the face in the studied room as a proportion of all face placements to context-correct (green) and context-incorrect (blue) sides of the building. (b) The correlation between bilateral ventromedial prefrontal cortex volume and both correct novel face placements (purple) and Triad Scores (studied room placements on the context-incorrect side of the building divided by studied room placements to the context-correct side of the building; teal). All behavioral data were z-scored for presentation purposes.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664414&req=5

pone.0143832.g009: Behavior and volumetric relationships.(a) The correlation between bilateral hippocampal volume and preference for placing the face in the studied room as a proportion of all face placements to context-correct (green) and context-incorrect (blue) sides of the building. (b) The correlation between bilateral ventromedial prefrontal cortex volume and both correct novel face placements (purple) and Triad Scores (studied room placements on the context-incorrect side of the building divided by studied room placements to the context-correct side of the building; teal). All behavioral data were z-scored for presentation purposes.
Mentions: Volumetric data were also acquired from cortical and subcortical brain structures for older adult participants. Given the vast literature summarizing hippocampal involvement in binding arbitrary relations among stimuli in a host of relational memory tasks (e.g., [27–34]), the relationship between hippocampal volume (controlling for cranial volume) and memory performance on this novel task was investigated. Controlling for age, hippocampal volume positively correlated with the proportion of responses to studied rooms (CC-studied and CI-studied combined), r = .56, p = .013. Bilateral hippocampal volume also positively correlated with the proportion of CC-studied rooms over all other rooms on the CC side of the building, r = .59, p = .008 (Fig 9a). There was a non-significant trend for the relationship between bilateral hippocampal volume and the proportion of CI-studied rooms over all other rooms on the CI side of the building, r = .42, p = .075 (Fig 9a). Taken together, these data demonstrate that older adults with larger hippocampi were better at selecting a studied room than those with smaller hippocampi.

Bottom Line: In this task, participants learned unique face-room associations in two distinct contexts (i.e., different colored buildings).Overall, performance was very accurate.This novel task provides a powerful tool for investigating both the unique and interacting contributions of these systems in support of relational memory.

View Article: PubMed Central - PubMed

Affiliation: University of Illinois, Beckman Institute for Advanced Science and Technology, Urbana, IL, United States of America.

ABSTRACT
Mnemonic processing engages multiple systems that cooperate and compete to support task performance. Exploring these systems' interaction requires memory tasks that produce rich data with multiple patterns of performance sensitive to different processing sub-components. Here we present a novel context-dependent relational memory paradigm designed to engage multiple learning and memory systems. In this task, participants learned unique face-room associations in two distinct contexts (i.e., different colored buildings). Faces occupied rooms as determined by an implicit gender-by-side rule structure (e.g., male faces on the left and female faces on the right) and all faces were seen in both contexts. In two experiments, we use behavioral and eye-tracking measures to investigate interactions among different memory representations in both younger and older adult populations; furthermore we link these representations to volumetric variations in hippocampus and ventromedial PFC among older adults. Overall, performance was very accurate. Successful face placement into a studied room systematically varied with hippocampal volume. Selecting the studied room in the wrong context was the most typical error. The proportion of these errors to correct responses positively correlated with ventromedial prefrontal volume. This novel task provides a powerful tool for investigating both the unique and interacting contributions of these systems in support of relational memory.

Show MeSH
Related in: MedlinePlus