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Association of Habitual Patterns and Types of Physical Activity and Inactivity with MRI-Determined Total Volumes of Visceral and Subcutaneous Abdominal Adipose Tissue in a General White Population.

Fischer K, Rüttgers D, Müller HP, Jacobs G, Kassubek J, Lieb W, Nöthlings U - PLoS ONE (2015)

Bottom Line: There was also evidence of a threshold effect in some of these relationships.In conclusion, our results suggest that in white populations, habitual APAT rich in MPA might be insufficient to impact on accumulation of VAT or SAAT.APAT including ≥ 4.0-6.8 h/wk VPA, by contrast, are more strongly associated with lower VAT and SAAT.

View Article: PubMed Central - PubMed

Affiliation: Department of Nutrition and Food Sciences, University of Bonn, Bonn, Germany.

ABSTRACT
Population-based evidence for the role of habitual physical activity (PA) in the accumulation of visceral (VAT) and subcutaneous (SAAT) abdominal adipose tissue is limited. We investigated if usual patterns and types of self-reported PA and inactivity were associated with VAT and SAAT in a general white population. Total volumes of VAT and SAAT were quantified by magnetic resonance imaging in 583 men and women (61 ± 11.9 y; BMI 27.2 ± 4.4 kg/m2). Past-year PA and inactivity were self-reported by questionnaire. Exploratory activity patterns (APAT) were derived by principal components analysis. Cross-sectional associations between individual activities, total PA in terms of metabolic equivalents (PA MET), or overall APAT and either VAT or SAAT were analyzed by multivariable-adjusted robust or generalized linear regression models. Whereas vigorous-intensity PA (VPA) was negatively associated with both VAT and SAAT, associations between total PA MET, moderate-intensity PA (MPA), or inactivity and VAT and/or SAAT depended on sex. There was also evidence of a threshold effect in some of these relationships. Total PA MET was more strongly associated with VAT in men (B = -3.3 ± 1.4; P = 0.02) than women (B = -2.1 ± 1.1; P = 0.07), but was more strongly associated with SAAT in women (B = -5.7 ± 2.5; P = 0.05) than men (B = -1.7 ± 1.6; P = 0.3). Men (-1.52 dm3 or -1.89 dm3) and women (-1.15 dm3 or -2.61 dm3) in the highest (>6.8 h/wk VPA) or second (4.0-6.8 h/wk VPA) tertile of an APAT rich in VPA, had lower VAT and SAAT, respectively, than those in the lowest (<4.0 h/wk VPA) tertile (P ≤ 0.016; P trend ≤ 0.0005). They also had lower VAT and SAAT than those with APAT rich in MPA and/or inactivity only. In conclusion, our results suggest that in white populations, habitual APAT rich in MPA might be insufficient to impact on accumulation of VAT or SAAT. APAT including ≥ 4.0-6.8 h/wk VPA, by contrast, are more strongly associated with lower VAT and SAAT.

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Total volumes of VAT and SAAT for tertiles of total physical activity (MET-h/wk) and for PCA-derived activity patterns by sex (M/ F) in Northern German adults.Data (n = 583 subjects) are LSM (± SE) of total volumes of (1) VAT or (2) SAAT from generalized linear models adjusted for age, total energy intake (kcal/d), smoking status (never, former, and current smoker), and height (final model 2) by tertile category and sex of PA MET and PCA-derived activity patterns (for exact data see also S2 Table). Multiple comparisons assessing statistical differences in LSM between tertiles were corrected by using the Tukey-Kramer procedure. Mean values without sharing a common superscript letter (a-c) were statistically different at P < 0.05. APAT 1–3; activity pattern 1 to 3 derived by PCA; B-Y FDR, Benjamini-Yekutieli false discovery rate; F, females; LSM, least-square mean; M, males; PA MET, metabolic equivalent hours per week of total physical activity (including housework, walking, gardening, do-it-yourself work, stair climbing, sports, cycling); PCA, principal components analysis; SAAT, subcutaneous abdominal adipose tissue; VAT, visceral abdominal adipose tissue.
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pone.0143925.g001: Total volumes of VAT and SAAT for tertiles of total physical activity (MET-h/wk) and for PCA-derived activity patterns by sex (M/ F) in Northern German adults.Data (n = 583 subjects) are LSM (± SE) of total volumes of (1) VAT or (2) SAAT from generalized linear models adjusted for age, total energy intake (kcal/d), smoking status (never, former, and current smoker), and height (final model 2) by tertile category and sex of PA MET and PCA-derived activity patterns (for exact data see also S2 Table). Multiple comparisons assessing statistical differences in LSM between tertiles were corrected by using the Tukey-Kramer procedure. Mean values without sharing a common superscript letter (a-c) were statistically different at P < 0.05. APAT 1–3; activity pattern 1 to 3 derived by PCA; B-Y FDR, Benjamini-Yekutieli false discovery rate; F, females; LSM, least-square mean; M, males; PA MET, metabolic equivalent hours per week of total physical activity (including housework, walking, gardening, do-it-yourself work, stair climbing, sports, cycling); PCA, principal components analysis; SAAT, subcutaneous abdominal adipose tissue; VAT, visceral abdominal adipose tissue.

Mentions: Stratified by sex and tertile category of PA MET (S2 Table and Fig 1), in multivariable analysis adjusted for height (final model 2), there was a non B-Y FDR significant inverse linear trend (Ptrend < 0.05) for the association between PA MET and VAT and SAAT in both men and women. However, compared with subjects in the lowest tertile (PA MET < 74.1), volumes of VAT or SAAT, respectively, were only significantly lower among men (-0.61 dm3 [-12.0%] or -0.71 dm3 [-11.2%]) and women (-0.44 dm3 [-14.2%] or -1.56 dm3 [-17.2%]) in the highest tertile (PA MET > 121.9), but not among subjects in the second tertile.


Association of Habitual Patterns and Types of Physical Activity and Inactivity with MRI-Determined Total Volumes of Visceral and Subcutaneous Abdominal Adipose Tissue in a General White Population.

Fischer K, Rüttgers D, Müller HP, Jacobs G, Kassubek J, Lieb W, Nöthlings U - PLoS ONE (2015)

Total volumes of VAT and SAAT for tertiles of total physical activity (MET-h/wk) and for PCA-derived activity patterns by sex (M/ F) in Northern German adults.Data (n = 583 subjects) are LSM (± SE) of total volumes of (1) VAT or (2) SAAT from generalized linear models adjusted for age, total energy intake (kcal/d), smoking status (never, former, and current smoker), and height (final model 2) by tertile category and sex of PA MET and PCA-derived activity patterns (for exact data see also S2 Table). Multiple comparisons assessing statistical differences in LSM between tertiles were corrected by using the Tukey-Kramer procedure. Mean values without sharing a common superscript letter (a-c) were statistically different at P < 0.05. APAT 1–3; activity pattern 1 to 3 derived by PCA; B-Y FDR, Benjamini-Yekutieli false discovery rate; F, females; LSM, least-square mean; M, males; PA MET, metabolic equivalent hours per week of total physical activity (including housework, walking, gardening, do-it-yourself work, stair climbing, sports, cycling); PCA, principal components analysis; SAAT, subcutaneous abdominal adipose tissue; VAT, visceral abdominal adipose tissue.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664408&req=5

pone.0143925.g001: Total volumes of VAT and SAAT for tertiles of total physical activity (MET-h/wk) and for PCA-derived activity patterns by sex (M/ F) in Northern German adults.Data (n = 583 subjects) are LSM (± SE) of total volumes of (1) VAT or (2) SAAT from generalized linear models adjusted for age, total energy intake (kcal/d), smoking status (never, former, and current smoker), and height (final model 2) by tertile category and sex of PA MET and PCA-derived activity patterns (for exact data see also S2 Table). Multiple comparisons assessing statistical differences in LSM between tertiles were corrected by using the Tukey-Kramer procedure. Mean values without sharing a common superscript letter (a-c) were statistically different at P < 0.05. APAT 1–3; activity pattern 1 to 3 derived by PCA; B-Y FDR, Benjamini-Yekutieli false discovery rate; F, females; LSM, least-square mean; M, males; PA MET, metabolic equivalent hours per week of total physical activity (including housework, walking, gardening, do-it-yourself work, stair climbing, sports, cycling); PCA, principal components analysis; SAAT, subcutaneous abdominal adipose tissue; VAT, visceral abdominal adipose tissue.
Mentions: Stratified by sex and tertile category of PA MET (S2 Table and Fig 1), in multivariable analysis adjusted for height (final model 2), there was a non B-Y FDR significant inverse linear trend (Ptrend < 0.05) for the association between PA MET and VAT and SAAT in both men and women. However, compared with subjects in the lowest tertile (PA MET < 74.1), volumes of VAT or SAAT, respectively, were only significantly lower among men (-0.61 dm3 [-12.0%] or -0.71 dm3 [-11.2%]) and women (-0.44 dm3 [-14.2%] or -1.56 dm3 [-17.2%]) in the highest tertile (PA MET > 121.9), but not among subjects in the second tertile.

Bottom Line: There was also evidence of a threshold effect in some of these relationships.In conclusion, our results suggest that in white populations, habitual APAT rich in MPA might be insufficient to impact on accumulation of VAT or SAAT.APAT including ≥ 4.0-6.8 h/wk VPA, by contrast, are more strongly associated with lower VAT and SAAT.

View Article: PubMed Central - PubMed

Affiliation: Department of Nutrition and Food Sciences, University of Bonn, Bonn, Germany.

ABSTRACT
Population-based evidence for the role of habitual physical activity (PA) in the accumulation of visceral (VAT) and subcutaneous (SAAT) abdominal adipose tissue is limited. We investigated if usual patterns and types of self-reported PA and inactivity were associated with VAT and SAAT in a general white population. Total volumes of VAT and SAAT were quantified by magnetic resonance imaging in 583 men and women (61 ± 11.9 y; BMI 27.2 ± 4.4 kg/m2). Past-year PA and inactivity were self-reported by questionnaire. Exploratory activity patterns (APAT) were derived by principal components analysis. Cross-sectional associations between individual activities, total PA in terms of metabolic equivalents (PA MET), or overall APAT and either VAT or SAAT were analyzed by multivariable-adjusted robust or generalized linear regression models. Whereas vigorous-intensity PA (VPA) was negatively associated with both VAT and SAAT, associations between total PA MET, moderate-intensity PA (MPA), or inactivity and VAT and/or SAAT depended on sex. There was also evidence of a threshold effect in some of these relationships. Total PA MET was more strongly associated with VAT in men (B = -3.3 ± 1.4; P = 0.02) than women (B = -2.1 ± 1.1; P = 0.07), but was more strongly associated with SAAT in women (B = -5.7 ± 2.5; P = 0.05) than men (B = -1.7 ± 1.6; P = 0.3). Men (-1.52 dm3 or -1.89 dm3) and women (-1.15 dm3 or -2.61 dm3) in the highest (>6.8 h/wk VPA) or second (4.0-6.8 h/wk VPA) tertile of an APAT rich in VPA, had lower VAT and SAAT, respectively, than those in the lowest (<4.0 h/wk VPA) tertile (P ≤ 0.016; P trend ≤ 0.0005). They also had lower VAT and SAAT than those with APAT rich in MPA and/or inactivity only. In conclusion, our results suggest that in white populations, habitual APAT rich in MPA might be insufficient to impact on accumulation of VAT or SAAT. APAT including ≥ 4.0-6.8 h/wk VPA, by contrast, are more strongly associated with lower VAT and SAAT.

Show MeSH
Related in: MedlinePlus