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Intrahepatic Vascular Anatomy in Rats and Mice--Variations and Surgical Implications.

Sänger C, Schenk A, Schwen LO, Wang L, Gremse F, Zafarnia S, Kiessling F, Xie C, Wei W, Richter B, Dirsch O, Dahmen U - PLoS ONE (2015)

Bottom Line: Surgically relevant variations were primarily observed in portal venous supply.We showed that lobar borders of the liver do not always match vascular territorial borders.These findings are of importance for the design of new surgical procedures and for understanding eventual complications following hepatic surgery.

View Article: PubMed Central - PubMed

Affiliation: Universitätsklinikum Jena, Klinik für Allgemein-, Viszeral- und Gefäßchirurgie, Experimentelle Transplantationschirurgie, Jena, Germany.

ABSTRACT

Introduction: The intra-hepatic vascular anatomy in rodents, its variations and corresponding supplying and draining territories in respect to the lobar structure of the liver have not been described. We performed a detailed anatomical imaging study in rats and mice to allow for further refinement of experimental surgical approaches.

Methods: LEWIS-Rats and C57Bl/6N-Mice were subjected to ex-vivo imaging using μCT. The image data were used for semi-automated segmentation to extract the hepatic vascular tree as prerequisite for 3D visualization. The underlying vascular anatomy was reconstructed, analysed and used for determining hepatic vascular territories.

Results: The four major liver lobes have their own lobar portal supply and hepatic drainage territories. In contrast, the paracaval liver is supplied by various small branches from right and caudate portal veins and drains directly into the vena cava. Variations in hepatic vascular anatomy were observed in terms of branching pattern and distance of branches to each other. The portal vein anatomy is more variable than the hepatic vein anatomy. Surgically relevant variations were primarily observed in portal venous supply.

Conclusions: For the first time the key variations of intrahepatic vascular anatomy in mice and rats and their surgical implications were described. We showed that lobar borders of the liver do not always match vascular territorial borders. These findings are of importance for the design of new surgical procedures and for understanding eventual complications following hepatic surgery.

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General hepatic vascular anatomy in mice (schematic drawing).A) General scheme of portal vein anatomy. B) General scheme of hepatic vein anatomy. HV-Hepatic vein, ICL-inferior caudate lobe, MML-middle median lobe, LML-left median lobe, LLL-left lateral lobe, PV-portal vein, RIL-right inferior lobe, RML-right median lobe, RSL-right superior lobe, SCL-superior caudate lobe.
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pone.0141798.g003: General hepatic vascular anatomy in mice (schematic drawing).A) General scheme of portal vein anatomy. B) General scheme of hepatic vein anatomy. HV-Hepatic vein, ICL-inferior caudate lobe, MML-middle median lobe, LML-left median lobe, LLL-left lateral lobe, PV-portal vein, RIL-right inferior lobe, RML-right median lobe, RSL-right superior lobe, SCL-superior caudate lobe.

Mentions: We analyzed portal venous vascular trees of 12 C57Bl/6N mice. Since the lobar structure of the rat and mouse liver is very similar, the basic anatomical pattern of the vascular system is also very similar (Fig 3A). However, upon a detailed anatomical comparison we identified some differences. The anatomical variations and their surgical relevant implications are described in the text below and also in Table 2.


Intrahepatic Vascular Anatomy in Rats and Mice--Variations and Surgical Implications.

Sänger C, Schenk A, Schwen LO, Wang L, Gremse F, Zafarnia S, Kiessling F, Xie C, Wei W, Richter B, Dirsch O, Dahmen U - PLoS ONE (2015)

General hepatic vascular anatomy in mice (schematic drawing).A) General scheme of portal vein anatomy. B) General scheme of hepatic vein anatomy. HV-Hepatic vein, ICL-inferior caudate lobe, MML-middle median lobe, LML-left median lobe, LLL-left lateral lobe, PV-portal vein, RIL-right inferior lobe, RML-right median lobe, RSL-right superior lobe, SCL-superior caudate lobe.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664386&req=5

pone.0141798.g003: General hepatic vascular anatomy in mice (schematic drawing).A) General scheme of portal vein anatomy. B) General scheme of hepatic vein anatomy. HV-Hepatic vein, ICL-inferior caudate lobe, MML-middle median lobe, LML-left median lobe, LLL-left lateral lobe, PV-portal vein, RIL-right inferior lobe, RML-right median lobe, RSL-right superior lobe, SCL-superior caudate lobe.
Mentions: We analyzed portal venous vascular trees of 12 C57Bl/6N mice. Since the lobar structure of the rat and mouse liver is very similar, the basic anatomical pattern of the vascular system is also very similar (Fig 3A). However, upon a detailed anatomical comparison we identified some differences. The anatomical variations and their surgical relevant implications are described in the text below and also in Table 2.

Bottom Line: Surgically relevant variations were primarily observed in portal venous supply.We showed that lobar borders of the liver do not always match vascular territorial borders.These findings are of importance for the design of new surgical procedures and for understanding eventual complications following hepatic surgery.

View Article: PubMed Central - PubMed

Affiliation: Universitätsklinikum Jena, Klinik für Allgemein-, Viszeral- und Gefäßchirurgie, Experimentelle Transplantationschirurgie, Jena, Germany.

ABSTRACT

Introduction: The intra-hepatic vascular anatomy in rodents, its variations and corresponding supplying and draining territories in respect to the lobar structure of the liver have not been described. We performed a detailed anatomical imaging study in rats and mice to allow for further refinement of experimental surgical approaches.

Methods: LEWIS-Rats and C57Bl/6N-Mice were subjected to ex-vivo imaging using μCT. The image data were used for semi-automated segmentation to extract the hepatic vascular tree as prerequisite for 3D visualization. The underlying vascular anatomy was reconstructed, analysed and used for determining hepatic vascular territories.

Results: The four major liver lobes have their own lobar portal supply and hepatic drainage territories. In contrast, the paracaval liver is supplied by various small branches from right and caudate portal veins and drains directly into the vena cava. Variations in hepatic vascular anatomy were observed in terms of branching pattern and distance of branches to each other. The portal vein anatomy is more variable than the hepatic vein anatomy. Surgically relevant variations were primarily observed in portal venous supply.

Conclusions: For the first time the key variations of intrahepatic vascular anatomy in mice and rats and their surgical implications were described. We showed that lobar borders of the liver do not always match vascular territorial borders. These findings are of importance for the design of new surgical procedures and for understanding eventual complications following hepatic surgery.

Show MeSH