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On-Going Frontal Alpha Rhythms Are Dominant in Passive State and Desynchronize in Active State in Adult Gray Mouse Lemurs.

Infarinato F, Rahman A, Del Percio C, Lamberty Y, Bordet R, Richardson JC, Forloni G, Drinkenburg W, Lopez S, Aujard F, Babiloni C, Pifferi F, IMI project PharmaCog Consorti - PLoS ONE (2015)

Bottom Line: During active state, there was a reduction in alpha power density (8-12 Hz) and an increase of power density at slow frequencies (1-4 Hz).Relative EMG activity was related to EEG power density at 2-4 Hz (positive correlation) and at 8-12 Hz (negative correlation).These EEG markers may be an ideal experimental model for translational basic (motor science) and applied (pharmacological and non-pharmacological interventions) research in Neurophysiology.

View Article: PubMed Central - PubMed

Affiliation: IRCCS San Raffaele Pisana, Rome, Italy.

ABSTRACT
The gray mouse lemur (Microcebus murinus) is considered a useful primate model for translational research. In the framework of IMI PharmaCog project (Grant Agreement n°115009, www.pharmacog.org), we tested the hypothesis that spectral electroencephalographic (EEG) markers of motor and locomotor activity in gray mouse lemurs reflect typical movement-related desynchronization of alpha rhythms (about 8-12 Hz) in humans. To this aim, EEG (bipolar electrodes in frontal cortex) and electromyographic (EMG; bipolar electrodes sutured in neck muscles) data were recorded in 13 male adult (about 3 years) lemurs. Artifact-free EEG segments during active state (gross movements, exploratory movements or locomotor activity) and awake passive state (no sleep) were selected on the basis of instrumental measures of animal behavior, and were used as an input for EEG power density analysis. Results showed a clear peak of EEG power density at alpha range (7-9 Hz) during passive state. During active state, there was a reduction in alpha power density (8-12 Hz) and an increase of power density at slow frequencies (1-4 Hz). Relative EMG activity was related to EEG power density at 2-4 Hz (positive correlation) and at 8-12 Hz (negative correlation). These results suggest for the first time that the primate gray mouse lemurs and humans may share basic neurophysiologic mechanisms of synchronization of frontal alpha rhythms in awake passive state and their desynchronization during motor and locomotor activity. These EEG markers may be an ideal experimental model for translational basic (motor science) and applied (pharmacological and non-pharmacological interventions) research in Neurophysiology.

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Grand-average across gray mouse lemurs of the normalized electroencephalographic (EEG) power density spectra between 0 and 30 Hz relative to the active and passive behavioral states.These spectra refer to the daytime (N = 11) and nighttime (N = 6) periods of interest. Lemurs having an insufficient amount of artefact-free EEG epochs in the passive state for the final analysis were not considered (daytime: L#4 and L#10; nighttime: L#1, L#2, L#3, L#4, L#11, L#12, and L#13).
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pone.0143719.g001: Grand-average across gray mouse lemurs of the normalized electroencephalographic (EEG) power density spectra between 0 and 30 Hz relative to the active and passive behavioral states.These spectra refer to the daytime (N = 11) and nighttime (N = 6) periods of interest. Lemurs having an insufficient amount of artefact-free EEG epochs in the passive state for the final analysis were not considered (daytime: L#4 and L#10; nighttime: L#1, L#2, L#3, L#4, L#11, L#12, and L#13).

Mentions: Fig 1 shows the grand average across animals of the normalized EEG power density spectra (0–30 Hz) computed from lemur premotor cortex in the behavioral active and passive states. The data refer to daytime (N = 11 mouse lemurs having sufficient EEG epochs in both states) and nighttime (N = 6 mouse lemurs having sufficient EEG epochs in both states). In the EEG power density spectrum of the passive behavioral state, normalized EEG power density values showed a clear peak between 7 and 9 Hz, namely in the putative alpha range. Noteworthy, the normalized EEG power density values of this peak were lower (i.e. desynchronization) in the behavioral active compared to the passive state. Also, the normalized EEG power density values between 1 and 4 Hz, namely in the putative delta range, were higher (i.e. synchronization) in the former compared to the latter. This difference of the EEG variable was observed both in the daytime and nighttime data.


On-Going Frontal Alpha Rhythms Are Dominant in Passive State and Desynchronize in Active State in Adult Gray Mouse Lemurs.

Infarinato F, Rahman A, Del Percio C, Lamberty Y, Bordet R, Richardson JC, Forloni G, Drinkenburg W, Lopez S, Aujard F, Babiloni C, Pifferi F, IMI project PharmaCog Consorti - PLoS ONE (2015)

Grand-average across gray mouse lemurs of the normalized electroencephalographic (EEG) power density spectra between 0 and 30 Hz relative to the active and passive behavioral states.These spectra refer to the daytime (N = 11) and nighttime (N = 6) periods of interest. Lemurs having an insufficient amount of artefact-free EEG epochs in the passive state for the final analysis were not considered (daytime: L#4 and L#10; nighttime: L#1, L#2, L#3, L#4, L#11, L#12, and L#13).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664384&req=5

pone.0143719.g001: Grand-average across gray mouse lemurs of the normalized electroencephalographic (EEG) power density spectra between 0 and 30 Hz relative to the active and passive behavioral states.These spectra refer to the daytime (N = 11) and nighttime (N = 6) periods of interest. Lemurs having an insufficient amount of artefact-free EEG epochs in the passive state for the final analysis were not considered (daytime: L#4 and L#10; nighttime: L#1, L#2, L#3, L#4, L#11, L#12, and L#13).
Mentions: Fig 1 shows the grand average across animals of the normalized EEG power density spectra (0–30 Hz) computed from lemur premotor cortex in the behavioral active and passive states. The data refer to daytime (N = 11 mouse lemurs having sufficient EEG epochs in both states) and nighttime (N = 6 mouse lemurs having sufficient EEG epochs in both states). In the EEG power density spectrum of the passive behavioral state, normalized EEG power density values showed a clear peak between 7 and 9 Hz, namely in the putative alpha range. Noteworthy, the normalized EEG power density values of this peak were lower (i.e. desynchronization) in the behavioral active compared to the passive state. Also, the normalized EEG power density values between 1 and 4 Hz, namely in the putative delta range, were higher (i.e. synchronization) in the former compared to the latter. This difference of the EEG variable was observed both in the daytime and nighttime data.

Bottom Line: During active state, there was a reduction in alpha power density (8-12 Hz) and an increase of power density at slow frequencies (1-4 Hz).Relative EMG activity was related to EEG power density at 2-4 Hz (positive correlation) and at 8-12 Hz (negative correlation).These EEG markers may be an ideal experimental model for translational basic (motor science) and applied (pharmacological and non-pharmacological interventions) research in Neurophysiology.

View Article: PubMed Central - PubMed

Affiliation: IRCCS San Raffaele Pisana, Rome, Italy.

ABSTRACT
The gray mouse lemur (Microcebus murinus) is considered a useful primate model for translational research. In the framework of IMI PharmaCog project (Grant Agreement n°115009, www.pharmacog.org), we tested the hypothesis that spectral electroencephalographic (EEG) markers of motor and locomotor activity in gray mouse lemurs reflect typical movement-related desynchronization of alpha rhythms (about 8-12 Hz) in humans. To this aim, EEG (bipolar electrodes in frontal cortex) and electromyographic (EMG; bipolar electrodes sutured in neck muscles) data were recorded in 13 male adult (about 3 years) lemurs. Artifact-free EEG segments during active state (gross movements, exploratory movements or locomotor activity) and awake passive state (no sleep) were selected on the basis of instrumental measures of animal behavior, and were used as an input for EEG power density analysis. Results showed a clear peak of EEG power density at alpha range (7-9 Hz) during passive state. During active state, there was a reduction in alpha power density (8-12 Hz) and an increase of power density at slow frequencies (1-4 Hz). Relative EMG activity was related to EEG power density at 2-4 Hz (positive correlation) and at 8-12 Hz (negative correlation). These results suggest for the first time that the primate gray mouse lemurs and humans may share basic neurophysiologic mechanisms of synchronization of frontal alpha rhythms in awake passive state and their desynchronization during motor and locomotor activity. These EEG markers may be an ideal experimental model for translational basic (motor science) and applied (pharmacological and non-pharmacological interventions) research in Neurophysiology.

Show MeSH