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Leukocyte Telomere Length in Young Adults Born Preterm: Support for Accelerated Biological Ageing.

Smeets CC, Codd V, Samani NJ, Hokken-Koelega AC - PLoS ONE (2015)

Bottom Line: Gestational age was positively associated with LTL (r = 0.11, p = 0.02).The difference remained significant after adjustment for gender and size at birth (p = 0.001).Although we found no correlation between LTL and risk for CVD at this young adult age, this biological ageing indicator may contribute to CVD and other adult onset diseases at a later age in those born preterm.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, subdivision of Endocrinology, Erasmus University Medical Center, Rotterdam, The Netherlands.

ABSTRACT

Background: Subjects born preterm have an increased risk for age-associated diseases, such as cardiovascular disease in later life, but the underlying causes are largely unknown. Shorter leukocyte telomere length (LTL), a marker of biological age, is associated with increased risk of cardiovascular disease.

Objectives: To compare LTL between subjects born preterm and at term and to assess if LTL is associated with other putative cardiovascular risk factors at young adult age.

Methods: We measured mean LTL in 470 young adults. LTL was measured using a quantitative PCR assay and expressed as T/S ratio. We analyzed the influence of gestational age on LTL and compared LTL between subjects born preterm (n = 186) and at term (n = 284). Additionally, we analyzed the correlation between LTL and potential risk factors of cardiovascular disease.

Results: Gestational age was positively associated with LTL (r = 0.11, p = 0.02). Subjects born preterm had shorter LTL (mean (SD) T/S ratio = 3.12 (0.44)) than subjects born at term (mean (SD) T/S ratio = 3.25 (0.46)), p = 0.003). The difference remained significant after adjustment for gender and size at birth (p = 0.001). There was no association of LTL with any one of the putative risk factors analyzed.

Conclusions: Young adults born preterm have shorter LTL than young adults born at term. Although we found no correlation between LTL and risk for CVD at this young adult age, this biological ageing indicator may contribute to CVD and other adult onset diseases at a later age in those born preterm.

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Distributions of mean telomere lengths in subjects born preterm and at term.T/S ratio = Telomere to single-gene copy ratio; Preterm = gestational age < 37 wks; The horizontal bars represent the mean values.
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pone.0143951.g001: Distributions of mean telomere lengths in subjects born preterm and at term.T/S ratio = Telomere to single-gene copy ratio; Preterm = gestational age < 37 wks; The horizontal bars represent the mean values.

Mentions: Fig 1 shows the difference in LTL between subjects born preterm and at term. Unadjusted for possible confounders, subjects born preterm had significantly shorter LTL than subjects born at term (mean (SD) T/S of 3.12 (0.44) and 3.25 (0.46), respectively, p = 0.003). This difference remained significant after correction for gender, birth length SDS and birth weight SDS (Table 3, p = 0.001).


Leukocyte Telomere Length in Young Adults Born Preterm: Support for Accelerated Biological Ageing.

Smeets CC, Codd V, Samani NJ, Hokken-Koelega AC - PLoS ONE (2015)

Distributions of mean telomere lengths in subjects born preterm and at term.T/S ratio = Telomere to single-gene copy ratio; Preterm = gestational age < 37 wks; The horizontal bars represent the mean values.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664383&req=5

pone.0143951.g001: Distributions of mean telomere lengths in subjects born preterm and at term.T/S ratio = Telomere to single-gene copy ratio; Preterm = gestational age < 37 wks; The horizontal bars represent the mean values.
Mentions: Fig 1 shows the difference in LTL between subjects born preterm and at term. Unadjusted for possible confounders, subjects born preterm had significantly shorter LTL than subjects born at term (mean (SD) T/S of 3.12 (0.44) and 3.25 (0.46), respectively, p = 0.003). This difference remained significant after correction for gender, birth length SDS and birth weight SDS (Table 3, p = 0.001).

Bottom Line: Gestational age was positively associated with LTL (r = 0.11, p = 0.02).The difference remained significant after adjustment for gender and size at birth (p = 0.001).Although we found no correlation between LTL and risk for CVD at this young adult age, this biological ageing indicator may contribute to CVD and other adult onset diseases at a later age in those born preterm.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, subdivision of Endocrinology, Erasmus University Medical Center, Rotterdam, The Netherlands.

ABSTRACT

Background: Subjects born preterm have an increased risk for age-associated diseases, such as cardiovascular disease in later life, but the underlying causes are largely unknown. Shorter leukocyte telomere length (LTL), a marker of biological age, is associated with increased risk of cardiovascular disease.

Objectives: To compare LTL between subjects born preterm and at term and to assess if LTL is associated with other putative cardiovascular risk factors at young adult age.

Methods: We measured mean LTL in 470 young adults. LTL was measured using a quantitative PCR assay and expressed as T/S ratio. We analyzed the influence of gestational age on LTL and compared LTL between subjects born preterm (n = 186) and at term (n = 284). Additionally, we analyzed the correlation between LTL and potential risk factors of cardiovascular disease.

Results: Gestational age was positively associated with LTL (r = 0.11, p = 0.02). Subjects born preterm had shorter LTL (mean (SD) T/S ratio = 3.12 (0.44)) than subjects born at term (mean (SD) T/S ratio = 3.25 (0.46)), p = 0.003). The difference remained significant after adjustment for gender and size at birth (p = 0.001). There was no association of LTL with any one of the putative risk factors analyzed.

Conclusions: Young adults born preterm have shorter LTL than young adults born at term. Although we found no correlation between LTL and risk for CVD at this young adult age, this biological ageing indicator may contribute to CVD and other adult onset diseases at a later age in those born preterm.

Show MeSH
Related in: MedlinePlus