Limits...
Naringin Alleviates Diabetic Kidney Disease through Inhibiting Oxidative Stress and Inflammatory Reaction.

Chen F, Zhang N, Ma X, Huang T, Shao Y, Wu C, Wang Q - PLoS ONE (2015)

Bottom Line: According to our results, first we found that naringin relieved kidney injury, improved renal function and inhibited collagen formation and renal interstitial fibrosis.Moreover, the results suggested that naringin significantly resisted inflammatory reaction by inhibiting NF- κ B signaling pathway.Taken together, our results demonstrate that naringin effectively alleviates DKD, which provide theoretical basis for naringin clinically used to treatment of DKD.

View Article: PubMed Central - PubMed

Affiliation: Department of Geratology for Cadres, The First Affiliated Hospital of China Medical University, Shenyang 110001, People's Republic of China.

ABSTRACT
Naringin, a flavanone glycoside extracted from Citrus grandis Osbeck, has a wide range of pharmacological effects. In the present study we aimed at demonstrating the protective effect of naringin against diabetic kidney disease (DKD) and elucidating its possible molecular mechanism underlying. The beneficial effect of naringin was assessed in rats with streptozotocin (STZ)-induced diabetes and high glucose-induced HBZY-1 cells. According to our results, first we found that naringin relieved kidney injury, improved renal function and inhibited collagen formation and renal interstitial fibrosis. Second, we confirmed that naringin restrained oxidative stress by activating Nrf2 antioxidant pathway. Moreover, the results suggested that naringin significantly resisted inflammatory reaction by inhibiting NF- κ B signaling pathway. Taken together, our results demonstrate that naringin effectively alleviates DKD, which provide theoretical basis for naringin clinically used to treatment of DKD.

Show MeSH

Related in: MedlinePlus

Naringin mitigated changes of pathomorphology and kidney injury biochemical indexes.(A) The pathological changes of renal tissues were investigated by PAS staining(400×). The glomerular injury and tubular injury scores were shown. (B) Body weight and percentage change in weight of rats. (C) Food intake per rat per day. (D) The ratios of kidney weight/ body weight were calculated. The concentrations of BUN (E), Cr(F), and UP(G) were detected. Results represent three independent experiments. Data were expressed as means ± SD, n = 6.a-d Means with different superscripts are significantly different (P< 0.05).
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4664292&req=5

pone.0143868.g002: Naringin mitigated changes of pathomorphology and kidney injury biochemical indexes.(A) The pathological changes of renal tissues were investigated by PAS staining(400×). The glomerular injury and tubular injury scores were shown. (B) Body weight and percentage change in weight of rats. (C) Food intake per rat per day. (D) The ratios of kidney weight/ body weight were calculated. The concentrations of BUN (E), Cr(F), and UP(G) were detected. Results represent three independent experiments. Data were expressed as means ± SD, n = 6.a-d Means with different superscripts are significantly different (P< 0.05).

Mentions: As shown in Fig 2A, the pathological changes in kidney tissues were observed by PAS staining. Compared with control group, the glomerular and tubular injury was prominent in STZ-induced diabetic rats. Treatment with naringin significantly alleviated renal injury in diabetic rats. The body weights and food intake of rats and kidney injury biochemical indexes were assessed and shown in Fig 2B–2G. The body weights of diabetic rats were obviously decreased, while treatment with naringin could increase diabetic rats body weight significantly (P<0.05). The mean food intake, ratio of kidney weight/body weight and levels of BUN, Cr and UP were significantly elevated (P<0.05) in diabetic group compared with those in the control group, whereas in naringin treatment groups these indexes were reduced significantly.


Naringin Alleviates Diabetic Kidney Disease through Inhibiting Oxidative Stress and Inflammatory Reaction.

Chen F, Zhang N, Ma X, Huang T, Shao Y, Wu C, Wang Q - PLoS ONE (2015)

Naringin mitigated changes of pathomorphology and kidney injury biochemical indexes.(A) The pathological changes of renal tissues were investigated by PAS staining(400×). The glomerular injury and tubular injury scores were shown. (B) Body weight and percentage change in weight of rats. (C) Food intake per rat per day. (D) The ratios of kidney weight/ body weight were calculated. The concentrations of BUN (E), Cr(F), and UP(G) were detected. Results represent three independent experiments. Data were expressed as means ± SD, n = 6.a-d Means with different superscripts are significantly different (P< 0.05).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664292&req=5

pone.0143868.g002: Naringin mitigated changes of pathomorphology and kidney injury biochemical indexes.(A) The pathological changes of renal tissues were investigated by PAS staining(400×). The glomerular injury and tubular injury scores were shown. (B) Body weight and percentage change in weight of rats. (C) Food intake per rat per day. (D) The ratios of kidney weight/ body weight were calculated. The concentrations of BUN (E), Cr(F), and UP(G) were detected. Results represent three independent experiments. Data were expressed as means ± SD, n = 6.a-d Means with different superscripts are significantly different (P< 0.05).
Mentions: As shown in Fig 2A, the pathological changes in kidney tissues were observed by PAS staining. Compared with control group, the glomerular and tubular injury was prominent in STZ-induced diabetic rats. Treatment with naringin significantly alleviated renal injury in diabetic rats. The body weights and food intake of rats and kidney injury biochemical indexes were assessed and shown in Fig 2B–2G. The body weights of diabetic rats were obviously decreased, while treatment with naringin could increase diabetic rats body weight significantly (P<0.05). The mean food intake, ratio of kidney weight/body weight and levels of BUN, Cr and UP were significantly elevated (P<0.05) in diabetic group compared with those in the control group, whereas in naringin treatment groups these indexes were reduced significantly.

Bottom Line: According to our results, first we found that naringin relieved kidney injury, improved renal function and inhibited collagen formation and renal interstitial fibrosis.Moreover, the results suggested that naringin significantly resisted inflammatory reaction by inhibiting NF- κ B signaling pathway.Taken together, our results demonstrate that naringin effectively alleviates DKD, which provide theoretical basis for naringin clinically used to treatment of DKD.

View Article: PubMed Central - PubMed

Affiliation: Department of Geratology for Cadres, The First Affiliated Hospital of China Medical University, Shenyang 110001, People's Republic of China.

ABSTRACT
Naringin, a flavanone glycoside extracted from Citrus grandis Osbeck, has a wide range of pharmacological effects. In the present study we aimed at demonstrating the protective effect of naringin against diabetic kidney disease (DKD) and elucidating its possible molecular mechanism underlying. The beneficial effect of naringin was assessed in rats with streptozotocin (STZ)-induced diabetes and high glucose-induced HBZY-1 cells. According to our results, first we found that naringin relieved kidney injury, improved renal function and inhibited collagen formation and renal interstitial fibrosis. Second, we confirmed that naringin restrained oxidative stress by activating Nrf2 antioxidant pathway. Moreover, the results suggested that naringin significantly resisted inflammatory reaction by inhibiting NF- κ B signaling pathway. Taken together, our results demonstrate that naringin effectively alleviates DKD, which provide theoretical basis for naringin clinically used to treatment of DKD.

Show MeSH
Related in: MedlinePlus