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Uric Acid Levels Can Predict Metabolic Syndrome and Hypertension in Adolescents: A 10-Year Longitudinal Study.

Sun HL, Pei D, Lue KH, Chen YL - PLoS ONE (2015)

Bottom Line: However, uric acid levels failed to predict type 2 diabetes mellitus, and only predicted metabolic syndrome in males (hazard ratio: 1.658; p<0.05).The same results were found in multivariate adjusted analysis.However, uric acid levels did not affect the occurrence of type 2 diabetes in both genders.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Chung Shan Medical University Hospital, School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

ABSTRACT
The relationships between uric acid and chronic disease risk factors such as metabolic syndrome, type 2 diabetes mellitus, and hypertension have been studied in adults. However, whether these relationships exist in adolescents is unknown. We randomly selected 8,005 subjects who were between 10 to 15 years old at baseline. Measurements of uric acid were used to predict the future occurrence of metabolic syndrome, hypertension, and type 2 diabetes. In total, 5,748 adolescents were enrolled and followed for a median of 7.2 years. Using cutoff points of uric acid for males and females (7.3 and 6.2 mg/dl, respectively), a high level of uric acid was either the second or third best predictor for hypertension in both genders (hazard ratio: 2.920 for males, 5.222 for females; p<0.05). However, uric acid levels failed to predict type 2 diabetes mellitus, and only predicted metabolic syndrome in males (hazard ratio: 1.658; p<0.05). The same results were found in multivariate adjusted analysis. In conclusion, a high level of uric acid indicated a higher likelihood of developing hypertension in both genders and metabolic syndrome in males after 10 years of follow-up. However, uric acid levels did not affect the occurrence of type 2 diabetes in both genders.

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Kaplan-Meier plots of metabolic syndrome, hypertension and type 2 diabetes the uric acid level in both genders.
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pone.0143786.g003: Kaplan-Meier plots of metabolic syndrome, hypertension and type 2 diabetes the uric acid level in both genders.

Mentions: Fig 2 shows the results of the first part of the study, and the cutoff points derived from the ROC curves for male and female were 7.3 and 6.2 mg/dl, respectively. These values were then used as the grouping criteria to investigate the time effect and HR of the endpoints (Fig 3, Tables 2 and 3).


Uric Acid Levels Can Predict Metabolic Syndrome and Hypertension in Adolescents: A 10-Year Longitudinal Study.

Sun HL, Pei D, Lue KH, Chen YL - PLoS ONE (2015)

Kaplan-Meier plots of metabolic syndrome, hypertension and type 2 diabetes the uric acid level in both genders.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4664290&req=5

pone.0143786.g003: Kaplan-Meier plots of metabolic syndrome, hypertension and type 2 diabetes the uric acid level in both genders.
Mentions: Fig 2 shows the results of the first part of the study, and the cutoff points derived from the ROC curves for male and female were 7.3 and 6.2 mg/dl, respectively. These values were then used as the grouping criteria to investigate the time effect and HR of the endpoints (Fig 3, Tables 2 and 3).

Bottom Line: However, uric acid levels failed to predict type 2 diabetes mellitus, and only predicted metabolic syndrome in males (hazard ratio: 1.658; p<0.05).The same results were found in multivariate adjusted analysis.However, uric acid levels did not affect the occurrence of type 2 diabetes in both genders.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Chung Shan Medical University Hospital, School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

ABSTRACT
The relationships between uric acid and chronic disease risk factors such as metabolic syndrome, type 2 diabetes mellitus, and hypertension have been studied in adults. However, whether these relationships exist in adolescents is unknown. We randomly selected 8,005 subjects who were between 10 to 15 years old at baseline. Measurements of uric acid were used to predict the future occurrence of metabolic syndrome, hypertension, and type 2 diabetes. In total, 5,748 adolescents were enrolled and followed for a median of 7.2 years. Using cutoff points of uric acid for males and females (7.3 and 6.2 mg/dl, respectively), a high level of uric acid was either the second or third best predictor for hypertension in both genders (hazard ratio: 2.920 for males, 5.222 for females; p<0.05). However, uric acid levels failed to predict type 2 diabetes mellitus, and only predicted metabolic syndrome in males (hazard ratio: 1.658; p<0.05). The same results were found in multivariate adjusted analysis. In conclusion, a high level of uric acid indicated a higher likelihood of developing hypertension in both genders and metabolic syndrome in males after 10 years of follow-up. However, uric acid levels did not affect the occurrence of type 2 diabetes in both genders.

Show MeSH
Related in: MedlinePlus