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Phenytoin-induced acute hypersensitivity pneumonitis.

Periwal P, Joshi S, Gothi R, Talwar D - Lung India (2015 Nov-Dec)

Bottom Line: Lungs are target organs for toxic effects of various drugs due to many reasons.Diphenylhydantoin (DPH) is reported to have many extrapulmonary side effects.It requires detailed workup and exclusion of other causes along with evidence of improvement in the patient's condition after withholding DPH.

View Article: PubMed Central - PubMed

Affiliation: Metro Centre for Respiratory Diseases, Metro Hospitals and Heart Institute, Noida, Uttar Pradesh, India.

ABSTRACT
Lungs are target organs for toxic effects of various drugs due to many reasons. Diphenylhydantoin (DPH) is reported to have many extrapulmonary side effects. We are presenting a case of acute hypersensitivity pneumonitis (HP) secondary to DPH, presenting with respiratory failure. Acute HP with respiratory failure is an uncommon drug side effect of the DPH therapy and is a diagnosis of exclusion. It requires detailed workup and exclusion of other causes along with evidence of improvement in the patient's condition after withholding DPH.

No MeSH data available.


Related in: MedlinePlus

Chest X-ray on admission: Reticular shadows with GGO
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Figure 1: Chest X-ray on admission: Reticular shadows with GGO

Mentions: Hematology and biochemistry profile was within normal limits. Hematology and biochemistry profile was withinnormal limits. Chest X-ray(CXR) revealed bilateral diffuse haziness with prominent interstitial markings in the mid and lower zones [Figure 1]. His electrocardiogram (ECG) report was normal ECHO was done, which revealed an ejection fraction of 50% and left ventricular(LV) diastolic dysfunction grade 1. Results of serological tests for human immunodeficiency virus(HIV), hepatitis B surface antigen(HBsAg), hepatitis C virus(HCV), and fever profile were negative. Serum precipitins were negative to molds.


Phenytoin-induced acute hypersensitivity pneumonitis.

Periwal P, Joshi S, Gothi R, Talwar D - Lung India (2015 Nov-Dec)

Chest X-ray on admission: Reticular shadows with GGO
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663873&req=5

Figure 1: Chest X-ray on admission: Reticular shadows with GGO
Mentions: Hematology and biochemistry profile was within normal limits. Hematology and biochemistry profile was withinnormal limits. Chest X-ray(CXR) revealed bilateral diffuse haziness with prominent interstitial markings in the mid and lower zones [Figure 1]. His electrocardiogram (ECG) report was normal ECHO was done, which revealed an ejection fraction of 50% and left ventricular(LV) diastolic dysfunction grade 1. Results of serological tests for human immunodeficiency virus(HIV), hepatitis B surface antigen(HBsAg), hepatitis C virus(HCV), and fever profile were negative. Serum precipitins were negative to molds.

Bottom Line: Lungs are target organs for toxic effects of various drugs due to many reasons.Diphenylhydantoin (DPH) is reported to have many extrapulmonary side effects.It requires detailed workup and exclusion of other causes along with evidence of improvement in the patient's condition after withholding DPH.

View Article: PubMed Central - PubMed

Affiliation: Metro Centre for Respiratory Diseases, Metro Hospitals and Heart Institute, Noida, Uttar Pradesh, India.

ABSTRACT
Lungs are target organs for toxic effects of various drugs due to many reasons. Diphenylhydantoin (DPH) is reported to have many extrapulmonary side effects. We are presenting a case of acute hypersensitivity pneumonitis (HP) secondary to DPH, presenting with respiratory failure. Acute HP with respiratory failure is an uncommon drug side effect of the DPH therapy and is a diagnosis of exclusion. It requires detailed workup and exclusion of other causes along with evidence of improvement in the patient's condition after withholding DPH.

No MeSH data available.


Related in: MedlinePlus