Limits...
Prevalence and outcome of epidermal growth factor receptor mutations in non-squamous non-small cell lung cancer patients.

Kota R, Gundeti S, Gullipalli M, Linga VG, Maddali LS, Digumarti R - Lung India (2015 Nov-Dec)

Bottom Line: EGFR mutations were seen in 30.6% of the 111 evaluable specimens, with a significantly higher rate in females (44% vs 19.6% P = 0.0072) as compared to men and non-smokers (41% vs 12% P = 0.0013) as against smokers.Most common mutations were observed in exons 19 (71%) and 21 (25%).The estimated median progression free survival for patients with and without mutations when treated with upfront TKIs was 12 months and 3 months respectively and the estimated median overall survival for patients with and without mutations was 20 and 9 months respectively.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Oncology, Nizam's Institute of Medical Sciences, Hyderabad, Andhra Pradesh, India.

ABSTRACT

Background: Epidermal growth factor receptor (EGFR) mutation analysis has become an important part of the initial workup of non-squamous non-small cell lung cancer (NS-NSCLC) patients as it is now recognized both as a prognostic and predictive marker to therapy with EGFR tyrosine kinase inhibitors (TKI).

Aim: In this retrospective study conducted at a University hospital, we evaluated the prevalence of EGFR mutations in patients with NS-NSCLC, clinico-pathological correlation and outcome to treatment with EGFR TKIs.

Materials and methods: Case records of 147 patients of NS-NSCLC in whom EGFR mutation status was tested were screened. EGFR mutation analysis was done using DNA sequencing by real time polymerase chain reaction method from tissue and cell blocks prepared from core biopsy, fine needle aspiration cytology and pleural fluid specimens.

Results: EGFR mutations were seen in 30.6% of the 111 evaluable specimens, with a significantly higher rate in females (44% vs 19.6% P = 0.0072) as compared to men and non-smokers (41% vs 12% P = 0.0013) as against smokers. Most common mutations were observed in exons 19 (71%) and 21 (25%). The estimated median progression free survival for patients with and without mutations when treated with upfront TKIs was 12 months and 3 months respectively and the estimated median overall survival for patients with and without mutations was 20 and 9 months respectively.

Conclusion: This study from India, further establishes the importance of upfront EGFR mutation testing in all NS-NSCLC patients, not only to prognosticate, but also to identify that subset of patients who could benefit from EGFR TKI therapy, early in the course of their disease.

No MeSH data available.


Related in: MedlinePlus

Estimated median PFS for the EGFR mutant patients was 10 months, while the estimated median PFS for EGFR mutation negative patients was three months, P < 0.0001 by log rank test (Mantel Cox)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4663857&req=5

Figure 4: Estimated median PFS for the EGFR mutant patients was 10 months, while the estimated median PFS for EGFR mutation negative patients was three months, P < 0.0001 by log rank test (Mantel Cox)

Mentions: The estimated progression-free survival (PFS) of the patients harboring activated EGFR mutations treated with first-line TKIs was 12 months, whereas, in those patients with wild-type EGFR it was three months, P < 0.0001 by log rank test [Figure 4]. Similarly the estimated overall survival [Figure 5] was also significantly higher for patients with EGFR mutations as compared to those without (20 months vs. 9 months, P = 0.0002 by the log rank test). Skin rash (52%) and diarrhea (38%) were the most frequently observed toxicities in our study.


Prevalence and outcome of epidermal growth factor receptor mutations in non-squamous non-small cell lung cancer patients.

Kota R, Gundeti S, Gullipalli M, Linga VG, Maddali LS, Digumarti R - Lung India (2015 Nov-Dec)

Estimated median PFS for the EGFR mutant patients was 10 months, while the estimated median PFS for EGFR mutation negative patients was three months, P < 0.0001 by log rank test (Mantel Cox)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663857&req=5

Figure 4: Estimated median PFS for the EGFR mutant patients was 10 months, while the estimated median PFS for EGFR mutation negative patients was three months, P < 0.0001 by log rank test (Mantel Cox)
Mentions: The estimated progression-free survival (PFS) of the patients harboring activated EGFR mutations treated with first-line TKIs was 12 months, whereas, in those patients with wild-type EGFR it was three months, P < 0.0001 by log rank test [Figure 4]. Similarly the estimated overall survival [Figure 5] was also significantly higher for patients with EGFR mutations as compared to those without (20 months vs. 9 months, P = 0.0002 by the log rank test). Skin rash (52%) and diarrhea (38%) were the most frequently observed toxicities in our study.

Bottom Line: EGFR mutations were seen in 30.6% of the 111 evaluable specimens, with a significantly higher rate in females (44% vs 19.6% P = 0.0072) as compared to men and non-smokers (41% vs 12% P = 0.0013) as against smokers.Most common mutations were observed in exons 19 (71%) and 21 (25%).The estimated median progression free survival for patients with and without mutations when treated with upfront TKIs was 12 months and 3 months respectively and the estimated median overall survival for patients with and without mutations was 20 and 9 months respectively.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Oncology, Nizam's Institute of Medical Sciences, Hyderabad, Andhra Pradesh, India.

ABSTRACT

Background: Epidermal growth factor receptor (EGFR) mutation analysis has become an important part of the initial workup of non-squamous non-small cell lung cancer (NS-NSCLC) patients as it is now recognized both as a prognostic and predictive marker to therapy with EGFR tyrosine kinase inhibitors (TKI).

Aim: In this retrospective study conducted at a University hospital, we evaluated the prevalence of EGFR mutations in patients with NS-NSCLC, clinico-pathological correlation and outcome to treatment with EGFR TKIs.

Materials and methods: Case records of 147 patients of NS-NSCLC in whom EGFR mutation status was tested were screened. EGFR mutation analysis was done using DNA sequencing by real time polymerase chain reaction method from tissue and cell blocks prepared from core biopsy, fine needle aspiration cytology and pleural fluid specimens.

Results: EGFR mutations were seen in 30.6% of the 111 evaluable specimens, with a significantly higher rate in females (44% vs 19.6% P = 0.0072) as compared to men and non-smokers (41% vs 12% P = 0.0013) as against smokers. Most common mutations were observed in exons 19 (71%) and 21 (25%). The estimated median progression free survival for patients with and without mutations when treated with upfront TKIs was 12 months and 3 months respectively and the estimated median overall survival for patients with and without mutations was 20 and 9 months respectively.

Conclusion: This study from India, further establishes the importance of upfront EGFR mutation testing in all NS-NSCLC patients, not only to prognosticate, but also to identify that subset of patients who could benefit from EGFR TKI therapy, early in the course of their disease.

No MeSH data available.


Related in: MedlinePlus