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Double filtration plasmapheresis in a dog with multiple myeloma and hyperviscosity syndrome.

Lippi I, Perondi F, Ross SJ, Marchetti V, Lubas G, Guidi G - Open Vet J (2015)

Bottom Line: A 12 year old, 38 kg, mix-breed, intact male dog presented with a 20 day history of clinical signs consistent with hyperviscosity syndrome secondary to multiple myeloma.A significant (p<0.05) reduction in serum total protein, alpha-2 and gamma globulins was found following each treatment.These reductions were accompanied by a complete resolution, although temporary, of the clinical signs of hyperviscosity syndrome.

View Article: PubMed Central - PubMed

Affiliation: UC Veterinary Medical Center San Diego 10435 Sorrento Valley Rd, Suite 101, San Diego, CA 92121, USA.

ABSTRACT
A 12 year old, 38 kg, mix-breed, intact male dog presented with a 20 day history of clinical signs consistent with hyperviscosity syndrome secondary to multiple myeloma. The dog received three double filtration plasmapheresis treatments on day 0, 7 and 22 after presentation. A significant (p<0.05) reduction in serum total protein, alpha-2 and gamma globulins was found following each treatment. These reductions were accompanied by a complete resolution, although temporary, of the clinical signs of hyperviscosity syndrome. The present study reported for the first time the use of double filtration plasmapheresis to reduce clinical signs of hyperviscosity syndrome in a dog with multiple myeloma.

No MeSH data available.


Related in: MedlinePlus

Serum concentration of alpha-2 globulins before and after each plasmapheresis treatment. First treatment (T:1), second treatment (T:2), third treatment (T:3). Two-way ANOVA showed a significant reduction of alpha-2 globulins in the post-treatment sample (p=0.01).
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Figure 2: Serum concentration of alpha-2 globulins before and after each plasmapheresis treatment. First treatment (T:1), second treatment (T:2), third treatment (T:3). Two-way ANOVA showed a significant reduction of alpha-2 globulins in the post-treatment sample (p=0.01).

Mentions: The dog received treatments on day 0, 7 and 21 following presentation. No complications were encountered during the treatments, with the exception of poor catheter performance during the third treatment, that necessitated reversal of the arterial and venous lines. Pre-treatment blood samples were collected 10 minutes before the start of the procedure. Post-treatment blood samples were collected 15 seconds after the end of the procedure at a standard blood flow of 50 ml/min. The pre-treatment and post-treatment values of each plasmapheresis session (Table 2) were compared using a two-way ANOVA (p<0.05) and using standard statistics software (Fig. 1, Fig. 2, Fig. 3 and Fig. 4).


Double filtration plasmapheresis in a dog with multiple myeloma and hyperviscosity syndrome.

Lippi I, Perondi F, Ross SJ, Marchetti V, Lubas G, Guidi G - Open Vet J (2015)

Serum concentration of alpha-2 globulins before and after each plasmapheresis treatment. First treatment (T:1), second treatment (T:2), third treatment (T:3). Two-way ANOVA showed a significant reduction of alpha-2 globulins in the post-treatment sample (p=0.01).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663801&req=5

Figure 2: Serum concentration of alpha-2 globulins before and after each plasmapheresis treatment. First treatment (T:1), second treatment (T:2), third treatment (T:3). Two-way ANOVA showed a significant reduction of alpha-2 globulins in the post-treatment sample (p=0.01).
Mentions: The dog received treatments on day 0, 7 and 21 following presentation. No complications were encountered during the treatments, with the exception of poor catheter performance during the third treatment, that necessitated reversal of the arterial and venous lines. Pre-treatment blood samples were collected 10 minutes before the start of the procedure. Post-treatment blood samples were collected 15 seconds after the end of the procedure at a standard blood flow of 50 ml/min. The pre-treatment and post-treatment values of each plasmapheresis session (Table 2) were compared using a two-way ANOVA (p<0.05) and using standard statistics software (Fig. 1, Fig. 2, Fig. 3 and Fig. 4).

Bottom Line: A 12 year old, 38 kg, mix-breed, intact male dog presented with a 20 day history of clinical signs consistent with hyperviscosity syndrome secondary to multiple myeloma.A significant (p<0.05) reduction in serum total protein, alpha-2 and gamma globulins was found following each treatment.These reductions were accompanied by a complete resolution, although temporary, of the clinical signs of hyperviscosity syndrome.

View Article: PubMed Central - PubMed

Affiliation: UC Veterinary Medical Center San Diego 10435 Sorrento Valley Rd, Suite 101, San Diego, CA 92121, USA.

ABSTRACT
A 12 year old, 38 kg, mix-breed, intact male dog presented with a 20 day history of clinical signs consistent with hyperviscosity syndrome secondary to multiple myeloma. The dog received three double filtration plasmapheresis treatments on day 0, 7 and 22 after presentation. A significant (p<0.05) reduction in serum total protein, alpha-2 and gamma globulins was found following each treatment. These reductions were accompanied by a complete resolution, although temporary, of the clinical signs of hyperviscosity syndrome. The present study reported for the first time the use of double filtration plasmapheresis to reduce clinical signs of hyperviscosity syndrome in a dog with multiple myeloma.

No MeSH data available.


Related in: MedlinePlus