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Reduction of microalbuminuria in type-2 diabetes mellitus with angiotensin-converting enzyme inhibitor alone and with cilnidipine.

Singh VK, Mishra A, Gupta KK, Misra R, Patel ML - Indian J Nephrol (2015 Nov-Dec)

Bottom Line: After 1-year follow-up, reduction in microalbuminuria was found to be greater in Group II.In Group I microalbuminuria came down by 25.68 ± 21.40 while in Group II it reduced by 54.88 ± 13.84 (P < 0.001).We conclude that in diabetic population, cilnidipine has an additive effect in microalbuminuria reduction over and above the well-proven effect of ACE inhibitors.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, King George Medical University, Lucknow, Uttar Pradesh, India.

ABSTRACT
The aim of our study was to find out the antiproteinuric effect of enalapril angiotensin-converting enzyme (ACE inhibitor) alone or in combination with cilnidipine in patients with type-2 diabetes mellitus. The study was conducted on 71 patients with type-2 diabetes mellitus patients with hypertension and microalbuminuria. They were divided into two groups randomly as follows: Group I (enalaprilalone, n = 36) and Group II (enalapril with cilnidipine, n = 35). In both the groups, baseline 24 h urinary albumin was estimated and was repeated every 3 months upto 1-year. After 1-year follow-up, reduction in microalbuminuria was found to be greater in Group II. In Group I microalbuminuria came down by 25.68 ± 21.40 while in Group II it reduced by 54.88 ± 13.84 (P < 0.001). We conclude that in diabetic population, cilnidipine has an additive effect in microalbuminuria reduction over and above the well-proven effect of ACE inhibitors.

No MeSH data available.


Related in: MedlinePlus

Comparison of microalbuminuria between two groups at baseline and different follow-up intervals. Results are expressed as mean ± standard deviation. After 1-year, the level of microalbumin in Group 1 was 153.17 mm Hg while in Group 2, it was 93.51 mm Hg (P < 0.001)
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Figure 2: Comparison of microalbuminuria between two groups at baseline and different follow-up intervals. Results are expressed as mean ± standard deviation. After 1-year, the level of microalbumin in Group 1 was 153.17 mm Hg while in Group 2, it was 93.51 mm Hg (P < 0.001)

Mentions: The mean 24 h urinary albumin level in Group I at the start of study was 204.69 ± 50.34 mg and in Group II was 206.74 ± 50.95 mg. At the end of 12 months, the mean microalbuminuria level was 153.17 ± 54.10 mg in Group I and 93.51 ± 36.30 mg in Group II (P < 0.001). The mean percentage reduction from baseline at the end of 12 months in Group I was −25.68 ± 21.40% while in Group II it was −54.88 ± 13.84%, (P < 0.001) [Figures 2 and 3].


Reduction of microalbuminuria in type-2 diabetes mellitus with angiotensin-converting enzyme inhibitor alone and with cilnidipine.

Singh VK, Mishra A, Gupta KK, Misra R, Patel ML - Indian J Nephrol (2015 Nov-Dec)

Comparison of microalbuminuria between two groups at baseline and different follow-up intervals. Results are expressed as mean ± standard deviation. After 1-year, the level of microalbumin in Group 1 was 153.17 mm Hg while in Group 2, it was 93.51 mm Hg (P < 0.001)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663769&req=5

Figure 2: Comparison of microalbuminuria between two groups at baseline and different follow-up intervals. Results are expressed as mean ± standard deviation. After 1-year, the level of microalbumin in Group 1 was 153.17 mm Hg while in Group 2, it was 93.51 mm Hg (P < 0.001)
Mentions: The mean 24 h urinary albumin level in Group I at the start of study was 204.69 ± 50.34 mg and in Group II was 206.74 ± 50.95 mg. At the end of 12 months, the mean microalbuminuria level was 153.17 ± 54.10 mg in Group I and 93.51 ± 36.30 mg in Group II (P < 0.001). The mean percentage reduction from baseline at the end of 12 months in Group I was −25.68 ± 21.40% while in Group II it was −54.88 ± 13.84%, (P < 0.001) [Figures 2 and 3].

Bottom Line: After 1-year follow-up, reduction in microalbuminuria was found to be greater in Group II.In Group I microalbuminuria came down by 25.68 ± 21.40 while in Group II it reduced by 54.88 ± 13.84 (P < 0.001).We conclude that in diabetic population, cilnidipine has an additive effect in microalbuminuria reduction over and above the well-proven effect of ACE inhibitors.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, King George Medical University, Lucknow, Uttar Pradesh, India.

ABSTRACT
The aim of our study was to find out the antiproteinuric effect of enalapril angiotensin-converting enzyme (ACE inhibitor) alone or in combination with cilnidipine in patients with type-2 diabetes mellitus. The study was conducted on 71 patients with type-2 diabetes mellitus patients with hypertension and microalbuminuria. They were divided into two groups randomly as follows: Group I (enalaprilalone, n = 36) and Group II (enalapril with cilnidipine, n = 35). In both the groups, baseline 24 h urinary albumin was estimated and was repeated every 3 months upto 1-year. After 1-year follow-up, reduction in microalbuminuria was found to be greater in Group II. In Group I microalbuminuria came down by 25.68 ± 21.40 while in Group II it reduced by 54.88 ± 13.84 (P < 0.001). We conclude that in diabetic population, cilnidipine has an additive effect in microalbuminuria reduction over and above the well-proven effect of ACE inhibitors.

No MeSH data available.


Related in: MedlinePlus