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Reduction of microalbuminuria in type-2 diabetes mellitus with angiotensin-converting enzyme inhibitor alone and with cilnidipine.

Singh VK, Mishra A, Gupta KK, Misra R, Patel ML - Indian J Nephrol (2015 Nov-Dec)

Bottom Line: After 1-year follow-up, reduction in microalbuminuria was found to be greater in Group II.In Group I microalbuminuria came down by 25.68 ± 21.40 while in Group II it reduced by 54.88 ± 13.84 (P < 0.001).We conclude that in diabetic population, cilnidipine has an additive effect in microalbuminuria reduction over and above the well-proven effect of ACE inhibitors.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, King George Medical University, Lucknow, Uttar Pradesh, India.

ABSTRACT
The aim of our study was to find out the antiproteinuric effect of enalapril angiotensin-converting enzyme (ACE inhibitor) alone or in combination with cilnidipine in patients with type-2 diabetes mellitus. The study was conducted on 71 patients with type-2 diabetes mellitus patients with hypertension and microalbuminuria. They were divided into two groups randomly as follows: Group I (enalaprilalone, n = 36) and Group II (enalapril with cilnidipine, n = 35). In both the groups, baseline 24 h urinary albumin was estimated and was repeated every 3 months upto 1-year. After 1-year follow-up, reduction in microalbuminuria was found to be greater in Group II. In Group I microalbuminuria came down by 25.68 ± 21.40 while in Group II it reduced by 54.88 ± 13.84 (P < 0.001). We conclude that in diabetic population, cilnidipine has an additive effect in microalbuminuria reduction over and above the well-proven effect of ACE inhibitors.

No MeSH data available.


Related in: MedlinePlus

Flow chart of participants through the trial
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Figure 1: Flow chart of participants through the trial

Mentions: Total number of patients screened for microalbumiuria was 260. Out of these patients, 95 normoalbuminurc and 72 with overt proteinuria were excluded from the study. Out of these excluded patients, 54 patients were normotensive. Remaining 93 patients with type-2 diabetes mellitus were microalbuminuric and hypertensive. They were randomly allocated in the two groups: Group I-enalapril (n = 48) and Group II-enalapril with cilnidipine (n = 45). The baseline characteristics of the patients in the two groups are mentioned in Table 1. On comparison of characteristics in both the studied groups, the result was nonsignificant [Table 1 and Figure 1].


Reduction of microalbuminuria in type-2 diabetes mellitus with angiotensin-converting enzyme inhibitor alone and with cilnidipine.

Singh VK, Mishra A, Gupta KK, Misra R, Patel ML - Indian J Nephrol (2015 Nov-Dec)

Flow chart of participants through the trial
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663769&req=5

Figure 1: Flow chart of participants through the trial
Mentions: Total number of patients screened for microalbumiuria was 260. Out of these patients, 95 normoalbuminurc and 72 with overt proteinuria were excluded from the study. Out of these excluded patients, 54 patients were normotensive. Remaining 93 patients with type-2 diabetes mellitus were microalbuminuric and hypertensive. They were randomly allocated in the two groups: Group I-enalapril (n = 48) and Group II-enalapril with cilnidipine (n = 45). The baseline characteristics of the patients in the two groups are mentioned in Table 1. On comparison of characteristics in both the studied groups, the result was nonsignificant [Table 1 and Figure 1].

Bottom Line: After 1-year follow-up, reduction in microalbuminuria was found to be greater in Group II.In Group I microalbuminuria came down by 25.68 ± 21.40 while in Group II it reduced by 54.88 ± 13.84 (P < 0.001).We conclude that in diabetic population, cilnidipine has an additive effect in microalbuminuria reduction over and above the well-proven effect of ACE inhibitors.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, King George Medical University, Lucknow, Uttar Pradesh, India.

ABSTRACT
The aim of our study was to find out the antiproteinuric effect of enalapril angiotensin-converting enzyme (ACE inhibitor) alone or in combination with cilnidipine in patients with type-2 diabetes mellitus. The study was conducted on 71 patients with type-2 diabetes mellitus patients with hypertension and microalbuminuria. They were divided into two groups randomly as follows: Group I (enalaprilalone, n = 36) and Group II (enalapril with cilnidipine, n = 35). In both the groups, baseline 24 h urinary albumin was estimated and was repeated every 3 months upto 1-year. After 1-year follow-up, reduction in microalbuminuria was found to be greater in Group II. In Group I microalbuminuria came down by 25.68 ± 21.40 while in Group II it reduced by 54.88 ± 13.84 (P < 0.001). We conclude that in diabetic population, cilnidipine has an additive effect in microalbuminuria reduction over and above the well-proven effect of ACE inhibitors.

No MeSH data available.


Related in: MedlinePlus