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Primary Left Cardiac Angiosarcoma with Mitral Valve Involvement Accompanying Coronary Artery Disease.

Baran C, Durdu S, Eryilmaz S, Sirlak M, Akar AR - Case Rep Surg (2015)

Bottom Line: We report here on a 43-year-old female patient presenting with non-ST elevation myocardial infarction, severe mitral regurgitation, and mild mitral stenosis secondary to encroachment of the related structures by a primary cardiac angiosarcoma.Therefore, no further intervention was performed, except for left internal mammarian artery to left anterior descending artery anastomosis and biopsy.As far as we know, this case is unique with respect to its presentation.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiovascular Surgery, Ankara University School of Medicine, Cebeci Heart Center, Dikimevi, 06340 Ankara, Turkey.

ABSTRACT
We report here on a 43-year-old female patient presenting with non-ST elevation myocardial infarction, severe mitral regurgitation, and mild mitral stenosis secondary to encroachment of the related structures by a primary cardiac angiosarcoma. A coronary angiography revealed significant stenosis in the left main and left circumflex arteries and at exploration, the tumour was arising from posterior left atrial free wall, invading the posterior mitral leaflet, and extending into all of the pulmonary veins and pericardium. Therefore, no further intervention was performed, except for left internal mammarian artery to left anterior descending artery anastomosis and biopsy. As far as we know, this case is unique with respect to its presentation.

No MeSH data available.


Related in: MedlinePlus

Intraoperative situs with view through the intra-atrial septum (transseptal approach). The arrow marks the roughly 1 cm large tumour originating at the posterior leaflet of the mitral valve (a). Haematoxylin and Eosin stain displaying a tumour consisting of irregular neoplastic vascular channels surrounded by atypical spindle shaped and epithelioid tumour cells (×40) (b). In immunohistochemical staining the tumour cells are stained with CD31 (×40) (c) and focally with Pan CK (×20) (d) and S-100 (×20) (e). The cells are pleomorphic and atypical.
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fig2: Intraoperative situs with view through the intra-atrial septum (transseptal approach). The arrow marks the roughly 1 cm large tumour originating at the posterior leaflet of the mitral valve (a). Haematoxylin and Eosin stain displaying a tumour consisting of irregular neoplastic vascular channels surrounded by atypical spindle shaped and epithelioid tumour cells (×40) (b). In immunohistochemical staining the tumour cells are stained with CD31 (×40) (c) and focally with Pan CK (×20) (d) and S-100 (×20) (e). The cells are pleomorphic and atypical.

Mentions: After a right atriotomy with a transseptal incision/approach, a 1 × 1 cm lobulated solid mass, arising from the region of the posterior mitral leaflet in the posterior left atrial free wall and extending into all of the pulmonary veins, was observed (Figure 2(a)).


Primary Left Cardiac Angiosarcoma with Mitral Valve Involvement Accompanying Coronary Artery Disease.

Baran C, Durdu S, Eryilmaz S, Sirlak M, Akar AR - Case Rep Surg (2015)

Intraoperative situs with view through the intra-atrial septum (transseptal approach). The arrow marks the roughly 1 cm large tumour originating at the posterior leaflet of the mitral valve (a). Haematoxylin and Eosin stain displaying a tumour consisting of irregular neoplastic vascular channels surrounded by atypical spindle shaped and epithelioid tumour cells (×40) (b). In immunohistochemical staining the tumour cells are stained with CD31 (×40) (c) and focally with Pan CK (×20) (d) and S-100 (×20) (e). The cells are pleomorphic and atypical.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4663746&req=5

fig2: Intraoperative situs with view through the intra-atrial septum (transseptal approach). The arrow marks the roughly 1 cm large tumour originating at the posterior leaflet of the mitral valve (a). Haematoxylin and Eosin stain displaying a tumour consisting of irregular neoplastic vascular channels surrounded by atypical spindle shaped and epithelioid tumour cells (×40) (b). In immunohistochemical staining the tumour cells are stained with CD31 (×40) (c) and focally with Pan CK (×20) (d) and S-100 (×20) (e). The cells are pleomorphic and atypical.
Mentions: After a right atriotomy with a transseptal incision/approach, a 1 × 1 cm lobulated solid mass, arising from the region of the posterior mitral leaflet in the posterior left atrial free wall and extending into all of the pulmonary veins, was observed (Figure 2(a)).

Bottom Line: We report here on a 43-year-old female patient presenting with non-ST elevation myocardial infarction, severe mitral regurgitation, and mild mitral stenosis secondary to encroachment of the related structures by a primary cardiac angiosarcoma.Therefore, no further intervention was performed, except for left internal mammarian artery to left anterior descending artery anastomosis and biopsy.As far as we know, this case is unique with respect to its presentation.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiovascular Surgery, Ankara University School of Medicine, Cebeci Heart Center, Dikimevi, 06340 Ankara, Turkey.

ABSTRACT
We report here on a 43-year-old female patient presenting with non-ST elevation myocardial infarction, severe mitral regurgitation, and mild mitral stenosis secondary to encroachment of the related structures by a primary cardiac angiosarcoma. A coronary angiography revealed significant stenosis in the left main and left circumflex arteries and at exploration, the tumour was arising from posterior left atrial free wall, invading the posterior mitral leaflet, and extending into all of the pulmonary veins and pericardium. Therefore, no further intervention was performed, except for left internal mammarian artery to left anterior descending artery anastomosis and biopsy. As far as we know, this case is unique with respect to its presentation.

No MeSH data available.


Related in: MedlinePlus